Oxazinanes
Cayman Chemical Fingolimod hydrochloride
An immune modulator and a prodrug form of FTY720 phosphate; decreases the number of circulating lymphocytes in mice at 1 mg/kg; increases skin allograft survival in rats from 0.3-3 mg/kg; prevents disease development in a rat model of EAE; inhibits S1P lyase from 0.3-30 µM
Cayman Chemical HA1077 hydrochloride
A potent inhibitor of ROCK2, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug forms are marketed for the treatment of pulmonary arterial hypertension and stable angina
Cayman Chemical Fingolimod hydrochloride
An immune modulator and a prodrug form of FTY720 phosphate; decreases the number of circulating lymphocytes in mice at 1 mg/kg; increases skin allograft survival in rats from 0.3-3 mg/kg; prevents disease development in a rat model of EAE; inhibits S1P lyase from 0.3-30 µM
Cayman Chemical EthylLNIO hydrochloride
A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively)
Cayman Chemical FR122047 hydrochloride
A selective COX-1 inhibitor (IC50 = 0.028 µM for the human enzyme); selective for COX-1 over COX-2 (IC50 = 65 µM); inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation in human platelet-rich plasma (IC50 = 180-200 nM); unlike aspirin, it does not induce gastric damage at 100 mg/kg, p.o.; has an anti-inflammatory effect in a rat models of collagen-induced arthritis
Cayman Chemical GW 3965 hydrochloride
An orally-active agonist of LXRα and LXRβ, activating the human isoforms with EC50 values of 190 and 30 nM, respectively; alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism
Cayman Chemical DLthreoPDMP hydrochloride
An inhibitor of sphingolipid biosynthesis; inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates at 5 and 10 µM; reduces the synthesis of glucosylceramide increases cellular ceramide, and induces cell cycle arrest; increases Aβ42 and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity
Cayman Chemical SRT 1720 hydrochloride
A selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol; improves insulin sensitivity, lowers plasma, glucose and increases mitochondrial capacity in diet-induced obese and diabetic leptin-deficient ob/ob mice after one week of treatment with an oral dose of 100 mg/kg once daily.
Cayman Chemical Pargyline hydrochloride
An irreversible inhibitor of MAO (Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively); induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Dawley rats; prevents reactive oxygen species-mediated monocyte hypertrophy at a concentration of 10 µM
Sigma Aldrich Fine Chemicals Biosciences Prazosin hydrochloride 99.50MG
Prazosin is a member of the class of adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.
Medchemexpress LLC Quisinostat dihydrochloride | 875320-31-3 | C21H28Cl2N6O2 | 1 MG
Quisinostat dihydrochloride is an orally active, potent pan-HDAC inhibitor that demonstrates broad-spectrum antitumoral activity and can induce autophagy in neuroblastoma cells.
- Potent pan-HDAC inhibitor
- Exhibits broad-spectrum antitumoral activity
- Induces autophagy in neuroblastoma cells
- High purity of 99.05%
- Inhibits HDAC isozymes
- Displays broad-spectrum antiproliferative activity against solid and hematologic cancer cell lines
- Induces apoptosis
- Induces continuous H3 acetylation in tumor tissue in vivo
- Strongly inhibits the growth of large pre-established HCT116 colon xenografts
eMolecules 98-59-9 | 4-Toluenesulfonyl chloride | Oakwood Chemical | MFCD00007450 | 190.640 | C7H7ClO2S | 99.000 | Cc1ccc(cc1)S(Cl)(=O)=O | 100g | 537723977
4-Toluenesulfonyl chloride | Oakwood Chemical | 98-59-9 | MFCD00007450 | 190.640 | C7H7ClO2S | 99.000 | Cc1ccc(cc1)S(Cl)(=O)=O | 100g | 537723977
eMolecules 771-60-8 | 2,3,4,5,6-Pentafluoroaniline | AbaChemScene | MFCD00007643 | 183.081 | C6H2F5N | 97.000 | Nc1c(F)c(F)c(F)c(F)c1F | 25g | 391092938
2,3,4,5,6-Pentafluoroaniline | AbaChemScene | 771-60-8 | MFCD00007643 | 183.081 | C6H2F5N | 97.000 | Nc1c(F)c(F)c(F)c(F)c1F | 25g | 391092938
Sigma Aldrich Fine Chemicals Biosciences Nalmefene Hydrochloride 9850MG
Nalmefene Hydrochloride 9850MG