Oxolanes
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Medchemexpress LLC KTX-582 | 2573298-13-0 | 98.7% | 872.93 | 5 MG
KTX-582 is a potent IRAK4 degrader that can induce apoptosis in MYD88MT DLBCL and is efficient in inducing in vivo tumor regressions in a lymphoma model. It degrades IRAK4 in whole blood monocytes and lymphocytes with high potency.
- Potent IRAK4 degrader with DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros
- Induces apoptosis in MYD88MT DLBCL
- Efficient in inducing in vivo tumor regressions in a lymphoma model
- Degrades IRAK4 in whole blood monocytes and lymphocytes with IC50s of less than 0.05 μM
- Inhibits IRAK4 in human whole blood LPS TNFα with an IC50 of 0.05 to 1 μM
- Exhibits antiproliferative activity against human OCI-Ly10 cells (IC50: 14 nM)
