Piperazines

Organic heterocyclic compounds that consist of a six-membered ring with four carbon atoms and two nitrogen atoms at opposite positions in the ring.

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2,176

Apexbio Technology LLC AO/PI Staining Solution 250T

AO/PI Staining Solution contains two DNA fluorescent dyes Acridine Orange (AO) and Propidium Iodide (PI) AO is able to cross intact cell membranes and label nuclei in all cells (both live and dead) emitting green fluorescence In contrast PI can penetrate only compromised cell membranes thus staining exclusively the nuclei of dead cells emitting red fluorescence This staining solution is optimized for use with fluorescence-based cell counters to accurately count cells Traditional Trypan Blue staining has low specificity often leading to inaccurate counting results due to the inclusion of cell debris or residual red blood cells in PMBC samples Since AO and PI are DNA-specific dyes their use effectively eliminates interference from impurities and red blood cells enabling precise and accurate cell counting

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2,177

Apexbio Technology LLC Live-Dead Cell Staining Kit I (Calcein AM/PI) 500T

Calcein AM/PI Live-Dead Cell Staining Kit is a reagent kit used to distinguish between viable mammalian cells with esterase activity and dead cells The kit contains two probes Calcein AM and Propidium Iodide (PI) Calcein AM is a probe that stains live cells it is a derivative of Calcein with an added AM moiety which makes it more hydrophobic and allows better cell permeability Calcein AM itself is non-fluorescent but once it enters live cells it is hydrolyzed by intracellular esterases into Calcein which can emit strong green fluorescence PI is a probe for dead cells which enters only cells with compromised membranes staining them red The fluorescence intensities of these two probes reflect cell viability and toxicity The kit is easy to use 30 minutes of staining incubation After staining results can be detected using fluorescence microscopy fluorescence microplate readers or flow cytometry This kit is unsuitable for bacteria or fungi

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2,178

Cayman Chemical Dexrazoxane 25mg

An intracellular iron chelator and an inhibitor of topoisomerase IIα that is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury; scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), DPPH (IC50 = 3.5 μM), and ABTS+ (IC50 = 3.8 mM) free radicals

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2,179

Medchemexpress LLC 2-Aminoethyl diphenylborinate (2-APB) | 524-95-8 | 98.9% | 225.09 | 1 ML

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). It also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2, and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue.

Cell-permeable IP3R inhibitor
Inhibits store-operated Ca2+ (SOC) channel
Activates some TRP channels (V1, V2, and V3)
Exhibits inhibitory effects on vasospasm
Shows specific anti-inflammatory and antioxidant effects in neural tissue at high concentrations
For research use only

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2,180

Cayman Chemical BafIlomycIn A1 1mg

A bacterial metabolite with diverse biological activities; an inhibitor of V-ATPases (Ki = 0.5 nM in N. crassa vacuolar membranes); >1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases); inhibits autophagosome maturation and protein degradation in H-4-II-E cells at 100 nM; inhibits chloroquine-induced apoptosis in primary CGNs; reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 and Huh7 cells, as well as HEK293T cells expressing human ACE2, at 100 nM; reduces lung RNA copy numbers and viral pneumonia in ACE2 transgenic mice infected with SARS-CoV-2 at 0.1 mg/kg