Piperazines
Selleck Chemical LLC MPP dihydrochloride
Methyl-piperidino-pyrazole (MPP) dihydrochloride is a highly selective antagonist for estrogen receptor alpha (ER ) with an affinity 200 times greater than for estrogen receptor beta (ER ) It inhibits 17 -estradiol binding to ER by inducing conformational changes that alter the receptor s binding site and also increases the energy required for genistein s interaction with ER
Apexbio Technology LLC Copanlisib dihydrochloride 1402152-13-9 5mg
Copanlisib dihydrochloride (CAS 1402152-13-9) is a small-molecule inhibitor that selectively targets phosphoinositide 3-kinase (PI3K) isoforms and By inhibiting these PI3K subunits copanlisib disrupts PI3K/AKT signaling pathways that regulate cellular proliferation and survival leading to reduced tumor cell growth and induction of apoptosis This compound is utilized in biomedical research to investigate PI3K-mediated oncogenic processes particularly in studies related to relapsed or refractory follicular lymphoma and other hematologic malignancies dependent on aberrant PI3K activity
Medchemexpress LLC N-(Tert-Butoxycarbonyl)-L-neopentylglycine | 79777-82-5 | 98.5% | C12H23NO4 | 5 G
N-(Tert-Butoxycarbonyl)-L-neopentylglycine is a Glycine derivative, also known by synonyms like L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl- (9CI) and (S)-2-(tert-Butoxycarbonylamino)-4,4-dimethylpentanoic acid.
- For research use only
- Used as ergogenic supplements
- Influences secretion of anabolic hormones
- Supplies fuel during exercise
- Enhances mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
- Recognized as a beneficial ergogenic dietary substance
Apexbio Technology LLC LDK378 dihydrochloride 1380575-43-8 50mg
LDK378 dihydrochloride (CAS 1380575-43-8) is a potent inhibitor of anaplastic lymphoma kinase (ALK) a receptor tyrosine kinase in the insulin receptor superfamily Demonstrating an in vitro IC50 of 200 pM against ALK LDK378 also inhibits IGF-1R InsR and STK22D with IC50 values of 8 nM 7 nM and 23 nM respectively In cellular assays LDK378 suppresses proliferation of Ba/F3 cells expressing NPM-ALK and Karpas-299 human non-Hodgkin lymphoma cells with IC50 values of 22 8 nM and 26 nM This compound serves as a valuable tool for investigating ALK-driven signaling pathways and potential therapeutic strategies in oncology research
TARGETMOL CHEMICALS INC Simufilam dihydrochloride 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its alpha7nAChR/TLR4 associations and downstream pathologies.
Apexbio Technology LLC H-9 dihydrochloride 116700-36-8 50mg
H-9 dihydrochloride (CAS 116700-36-8) is a cell-permeable inhibitor of protein kinase A (PKA) used extensively to investigate protein kinase-dependent cellular signal transduction pathways By antagonizing PKA activity H-9 dihydrochloride has been shown to attenuate cellular excitatory responses induced by serotonin (5-HT) and to directly influence physiological functions in the pharyngeal region Additionally in epithelial cell models H-9 dihydrochloride inhibits epidermal growth factor (EGF)-dependent signaling cascades suppressing cell proliferation This compound is widely used in cell biology research to dissect kinase-mediated regulatory mechanisms
Apexbio Technology LLC CGH 2466 dihydrochloride 1177618-54-0 50mg
CGH 2466 dihydrochloride is a small-molecule antagonist targeting adenosine receptors with inhibitory activities against phosphodiesterase type 4 (PDE4) and p38 mitogen-activated protein kinase (MAPK) It is designed to block adenosine receptor signaling and inhibit key inflammatory enzymes thereby modulating inflammatory pathways CGH 2466 dihydrochloride exerts its biological activity primarily through selective inhibition of the PDE4D isoform (IC50 22 5 nM) and inhibition of p38 MAPK and isoforms (IC50 187 18 nM and 400 38 nM respectively) It shows comparable affinities to CGS15943 for the adenosine A1 A2B and A3 receptors but no activity at the A2A receptor Based on these pharmacological properties CGH 2466 dihydrochloride holds research potential in studies involving inflammatory mechanisms such as allergen-induced eosinophilic airway inflammation models
Medchemexpress LLC Dexrazoxane hydrochloride | 149003-01-0 | >99.8% | C11H18Cl2N4O4 | 50 MG
Dexrazoxane hydrochloride is a heart protectant with antioxidant and anti-inflammatory properties. It can cross the blood-brain barrier, improving motor function disorders and offering neuroprotective effects, making it useful in the study of neurodegenerative diseases. As a derivative of EDTA, it chelates iron, reducing the formation of superoxide radicals and protecting the heart against the cardiotoxic side effects of anthracyclines like doxorubicin.
- Heart protectant with antioxidant and anti-inflammatory properties
- Crosses the blood-brain barrier, improving motor function disorders
- Offers neuroprotective effects, useful in neurodegenerative disease studies
- Chelates iron, reducing superoxide radical formation
- Protects the heart against cardiotoxic side effects of anthracyclines
Selleck Chemical LLC CRT0066101 dihydrochloride
CRT0066101 dihydrochloride is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKC /PKC /PKC activity in multiple
Selleck Chemical LLC E6446 dihydrochloride
E6446 dihydrochloride is a specific Toll-like receptor 9 inhibitor
Medchemexpress LLC 2-aminoethyl-mono-amide-DOTA-tris(tBu ester) | 173308-19-5 | MFCD30533300 | 98.0% | 614.82 g/mol | C30H58N6O7 | 250 MG
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a protected DOTA-based chelator precursor supplied as a solid for research use in radiochemistry and targeted radiotherapy development. The tert-butyl ester groups protect carboxylates during synthesis and allow deprotection to yield a DOTA chelator that forms stable complexes with radiometals such as 68Ga and 177Lu for imaging and therapy applications.
- Protected DOTA chelator precursor for radiometal labeling.
- Compatible with conjugation to antibodies, peptides, and small molecules.
- Enables stable complexation with common radiometals (for example, 68Ga and 177Lu).
- High purity (98.0%) suitable for research applications.
- Solid form for convenient handling and storage.
- Useful in tumor pre-targeting and radiochemistry workflows.
Medchemexpress LLC 3'-O-(2-Methoxyethyl)adenosine | 303197-30-0 | C13H19N5O5 | 5 MG
3'-O-(2-Methoxyethyl)adenosine is an adenosine analogue that functions as a smooth muscle vasodilator and has shown to inhibit cancer progression. It is intended for research use only.
- Adenosine analogue
- Functions as smooth muscle vasodilator
- May impede cancer progression
- Purity: 99.87%