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Apexbio Technology LLC LDK378 dihydrochloride 1380575-43-8 10mg
Supplier: Apexbio Technology LLC A354410
LDK378 dihydrochloride (CAS 1380575-43-8) is a potent inhibitor of anaplastic lymphoma kinase (ALK) a receptor tyrosine kinase in the insulin receptor superfamily Demonstrating an in vitro IC50 of 200 pM against ALK LDK378 also inhibits IGF-1R InsR and STK22D with IC50 values of 8 nM 7 nM and 23 nM respectively In cellular assays LDK378 suppresses proliferation of Ba/F3 cells expressing NPM-ALK and Karpas-299 human non-Hodgkin lymphoma cells with IC50 values of 22 8 nM and 26 nM This compound serves as a valuable tool for investigating ALK-driven signaling pathways and potential therapeutic strategies in oncology research
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