Piperazines
Apexbio Technology LLC Veliparib dihydrochloride 912445-05-7 10mg
Veliparib dihydrochloride (CAS 912445-05-7) is a selective inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 enzymes responsible for DNA repair processes frequently upregulated in various cancers Veliparib inhibits PARP1 and PARP2 with K(i) values of 5 2 and 2 9 nmol/L respectively In colon cancer cell lines (HCT-116 HT-29) veliparib enhances DNA damage and induces G2/M arrest when combined with SN38 or oxaliplatin In preclinical murine melanoma (B16F10) breast cancer (MX-1) and colon cancer (HCT-116) xenografts combination therapy with DNA-damaging agents shows improved antitumor effects
Apexbio Technology LLC Veliparib dihydrochloride 912445-05-7 5mg
Veliparib dihydrochloride (CAS 912445-05-7) is a selective inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 enzymes responsible for DNA repair processes frequently upregulated in various cancers Veliparib inhibits PARP1 and PARP2 with K(i) values of 5 2 and 2 9 nmol/L respectively In colon cancer cell lines (HCT-116 HT-29) veliparib enhances DNA damage and induces G2/M arrest when combined with SN38 or oxaliplatin In preclinical murine melanoma (B16F10) breast cancer (MX-1) and colon cancer (HCT-116) xenografts combination therapy with DNA-damaging agents shows improved antitumor effects
Apexbio Technology LLC LDK378 dihydrochloride 1380575-43-8 100mg
LDK378 dihydrochloride (CAS 1380575-43-8) is a potent inhibitor of anaplastic lymphoma kinase (ALK) a receptor tyrosine kinase in the insulin receptor superfamily Demonstrating an in vitro IC50 of 200 pM against ALK LDK378 also inhibits IGF-1R InsR and STK22D with IC50 values of 8 nM 7 nM and 23 nM respectively In cellular assays LDK378 suppresses proliferation of Ba/F3 cells expressing NPM-ALK and Karpas-299 human non-Hodgkin lymphoma cells with IC50 values of 22 8 nM and 26 nM This compound serves as a valuable tool for investigating ALK-driven signaling pathways and potential therapeutic strategies in oncology research
Apexbio Technology LLC LDK378 dihydrochloride 1380575-43-8 50mg
LDK378 dihydrochloride (CAS 1380575-43-8) is a potent inhibitor of anaplastic lymphoma kinase (ALK) a receptor tyrosine kinase in the insulin receptor superfamily Demonstrating an in vitro IC50 of 200 pM against ALK LDK378 also inhibits IGF-1R InsR and STK22D with IC50 values of 8 nM 7 nM and 23 nM respectively In cellular assays LDK378 suppresses proliferation of Ba/F3 cells expressing NPM-ALK and Karpas-299 human non-Hodgkin lymphoma cells with IC50 values of 22 8 nM and 26 nM This compound serves as a valuable tool for investigating ALK-driven signaling pathways and potential therapeutic strategies in oncology research
Apexbio Technology LLC LDK378 dihydrochloride 1380575-43-8 10mg
LDK378 dihydrochloride (CAS 1380575-43-8) is a potent inhibitor of anaplastic lymphoma kinase (ALK) a receptor tyrosine kinase in the insulin receptor superfamily Demonstrating an in vitro IC50 of 200 pM against ALK LDK378 also inhibits IGF-1R InsR and STK22D with IC50 values of 8 nM 7 nM and 23 nM respectively In cellular assays LDK378 suppresses proliferation of Ba/F3 cells expressing NPM-ALK and Karpas-299 human non-Hodgkin lymphoma cells with IC50 values of 22 8 nM and 26 nM This compound serves as a valuable tool for investigating ALK-driven signaling pathways and potential therapeutic strategies in oncology research