Piperazines
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![Medchemexpress LLC Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-4-[[(2-hydroxyethyl)sulfonyl)amino]-N-[6-[(2R)-2-methyl-4- | 2410796-89-1 | 99.2% | C26H35N5O5S | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-4-[[(2-hydroxyethyl)sulfonyl)amino]-N-[6-[(2R)-2-methyl-4- | 2410796-89-1 | 99.2% | C26H35N5O5S | 25 MG
AM-5308 is a KIF18A inhibitor (IC50 47 nM) that also inhibits KIF19A (IC50 0.224 μM) and KIF18B (IC50 17.73 μM) motor activity. It activates mitotic checkpoints, regulating cell division processes such as chromosome segregation and spindle assembly. Demonstrating antitumor activity, AM-5308 shows in vitro cytotoxicity in human bone marrow cells and arrests the cell cycle of MDA-MB-157 cells in mitosis (EC50 0.041 μM). In vivo, it inhibits tumor growth in mouse OVCAR-3 xenograft models.
- Inhibits KIF18A, KIF19A, and KIF18B motor activity.
- Activates mitotic checkpoints and regulates cell division.
- Demonstrates antitumor activity in vitro and in vivo.
- Induces cytotoxicity and cell cycle arrest in human bone marrow and MDA-MB-157 cells.
