Piperazinoazepines
Medchemexpress LLC Mirtazapine | 85650-52-8 | 99.9% | 500 MG
Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist, influencing norepinephrine and 5-HT1A-mediated serotonergic transmission. It is primarily metabolized by CYP1A2, CYP2D6, and CYP3A4.
- Potent and orally active antidepressant
- Acts as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist
- Enhances release of norepinephrine
- Enhances 5-HT1A-mediated serotonergic transmission
- Reduces activation-induced release of cytokine/chemo kine mediators from human CD14+ monocytes in vitro
- Inhibits Con A-induced liver injury in vivo by suppressing hepatic macrophage/monocyte activation and pro-inflammatory cytokine production
Medchemexpress LLC Mianserin hydrochloride | 21535-47-7 | 99.95% | 500 MG
Mianserin hydrochloride is an orally active H1 receptor antagonist and can activate κ-opioid receptor and octopamine receptor. It can be used for the research of neurological diseases such as depression and epilepsy.
- Solid appearance
- Melting/freezing point >230°C
- Stable under recommended storage conditions
- Increases ERK1/2 and CREB phosphorylation
- Modulates social and exploratory behavior
- Raises electroconvulsive thresholds
TARGETMOL CHEMICALS INC MIRTAZAPINE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. purity: 99%