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Medchemexpress LLC Mirtazapine | 85650-52-8 | 99.9% | 500 MG
Supplier: Medchemexpress LLC HYB0352500MG
Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist, influencing norepinephrine and 5-HT1A-mediated serotonergic transmission. It is primarily metabolized by CYP1A2, CYP2D6, and CYP3A4.
- Potent and orally active antidepressant
- Acts as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist
- Enhances release of norepinephrine
- Enhances 5-HT1A-mediated serotonergic transmission
- Reduces activation-induced release of cytokine/chemo kine mediators from human CD14+ monocytes in vitro
- Inhibits Con A-induced liver injury in vivo by suppressing hepatic macrophage/monocyte activation and pro-inflammatory cytokine production
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