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Piperazinoazepines

Organic heterocyclic compounds that consist of an azepine ring and a piperazine ring connected by a carbon-nitrogen bridge; piperazine is a six-membered ring with four carbon atoms and two nitrogen atoms at opposite positions in the ring.

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Medchemexpress LLC Mirtazapine | 85650-52-8 | MFCD00865427 | 99.9% | 25 MG
SDP

Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It acts as an antagonist for 5-HT2, 5-HT3, histamine H1 receptors, and α2-adrenoceptors. This compound is intended for research use only and is not sold to patients.

  • Potent and orally active NaSSA agent
  • Antagonist of multiple receptors: 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor
  • Enhances norepinephrine and 5-HT1A-mediated serotonergic transmission
  • Inhibits hepatic macrophage/monocyte activation, decreases pro-inflammatory cytokine and chemokine production, and suppresses ICAM-1 expression, leading to reduced neutrophil recruitment into the liver (observed in mice)
  • Metabolized by CYP1A2, CYP2D6, and CYP3A4 isoenzymes
  • Significantly reduces activation-induced release of cytokine/chemokine mediators from human CD14+ monocytes in vitro

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