Piperidines
Medchemexpress LLC PI-103 | 371935-74-9 | 99.8% | 348.36 | 25 MG
PI-103 is a potent PI3K and mTOR inhibitor that also inhibits DNA-PK and induces autophagy. It shows antiproliferative effects in human cancer cell lines, leading to cell cycle arrest, inhibition of leukemic proliferation, and mitochondrial apoptosis. In vivo, it demonstrates therapeutic activity against human tumor xenografts, inhibiting angiogenesis, invasion, and metastasis.
- Potent PI3K and mTOR inhibitor
- Inhibits DNA-PK
- Induces autophagy
- Demonstrates antiproliferative properties in human cancer cell lines
- Induces cell cycle arrest in G1 phase
- Inhibits leukemic proliferation and mitochondrial apoptosis
- Exhibits therapeutic activity against human tumor xenografts
- Inhibits angiogenesis, invasion, and metastasis
- Provides direct antiproliferative effects
Apexbio Technology LLC AT7867 857531-00-1 5mg
AT7867 (CAS 857531-00-1) is a small molecule ATP-competitive inhibitor that targets Akt1 Akt2 Akt3 p70S6 kinase (p70S6K) and protein kinase A (PKA) with reported IC50 values of 32 nM 17 nM 47 nM 85 nM and 20 nM respectively Akt or protein kinase B is a serine/threonine kinase involved in cellular pathways such as glucose metabolism apoptosis proliferation transcription and migration AT7867 suppresses proliferation across various human tumor cell lines including MES-SA MDA-MB-468 MCF-7 HCT116 and HT29 with IC50 values ranging from 0 9 to 3 M Additionally it inhibits GSK3 within these lines (IC50 2 4 M) and induces apoptosis in U87MG glioblastoma cells via dose- and time-dependent Akt pathway inhibition In PTEN-deficient tumor xenograft models AT7867 reduces phosphorylation of Akt/p70S6K substrates and impedes tumor growth supporting its use in cancer research
Matrix Scientific 1-(TERT-BUTYL) 4-METHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE MF C12H21NO4 MW 243.31 CAS 124443-68-1 MDL MFCD02183584 QTY 5 UO
1-(TERT-BUTYL) 4-METHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE MF C12H21NO4 MW 243.31 CAS 124443-68-1 MDL MFCD02183584 QTY 5 UOM G
Medchemexpress LLC HY-12726 5mg Medchemexpress, Liproxstatin-1 CAS:950455-15-9 Purity:>98%
Medchemexpress, HY-12726 5mg Liproxstatin-1 CAS:950455-15-9 Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Accela Chembio Inc Methyl N-methyl-4-piperidinecarboxylate | 5g | 1690-75-1 | MFCD06658483 | 95+% | Shelf Life: 1260 Days | Light Sensitive/nitrogen Or Argon/+4
Methyl N-methyl-4-piperidinecarboxylate | 5g | 1690-75-1 | MFCD06658483 | 95+% | Shelf Life: 1260 Days | Light Sensitive/nitrogen Or Argon/+4
![eMolecules 1192491-61-4 | Avibactam sodium | Combi-Blocks | MFCD28900719 | 287.220 | C7H10N3NaO6S | 97.000 | [Na+].NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS([O-])(=O)=O | 1g | 415501240](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3072086.JPG-250.jpg)
eMolecules 1192491-61-4 | Avibactam sodium | Combi-Blocks | MFCD28900719 | 287.220 | C7H10N3NaO6S | 97.000 | [Na+].NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS([O-])(=O)=O | 1g | 415501240
Avibactam sodium | Combi-Blocks | 1192491-61-4 | MFCD28900719 | 287.220 | C7H10N3NaO6S | 97.000 | [Na+].NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS([O-])(=O)=O | 1g | 415501240
Chem-Impex International, Inc. Isonipecotic acid | 498-94-2 | MFCD00006004 | 25G
Isonipecotic acid, 498-94-2, MFCD00006004, 25G
Medchemexpress LLC Alectinib | 1256580-46-7 | MFCD19440988 | 5mg
Alectinib | Purity: 99.87% | MW: 482.62 | 1256580-46-7 | MFCD19440988 | 5mg
![eMolecules 540737-29-9 | Tofacitinib citrate | J & W PharmLab LLC | MFCD28398116 | 504.500 | C22H28N6O8 | 96.000 | OC(=O)CC(O)(CC(O)=O)C(O)=O.C[C@H]1CCN(C[C@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N | 1g | 271113125](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502147309.JPG-250.jpg)
eMolecules 540737-29-9 | Tofacitinib citrate | J & W PharmLab LLC | MFCD28398116 | 504.500 | C22H28N6O8 | 96.000 | OC(=O)CC(O)(CC(O)=O)C(O)=O.C[C@H]1CCN(C[C@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N | 1g | 271113125
Tofacitinib citrate | J & W PharmLab LLC | 540737-29-9 | MFCD28398116 | 504.500 | C22H28N6O8 | 96.000 | OC(=O)CC(O)(CC(O)=O)C(O)=O.C[C@H]1CCN(C[C@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N | 1g | 271113125
Enzo Life Sciences Ceritinib (free base) (200mg). CAS: 1032900-25-6
Ceritinib is a selective inhibitor of ALK, a target found in metastatic non-small cell lung cancer. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Aobchem 2-Formylphenylboronic acid pinacol ester | ≥97% | CAS 380151-85-9 | C13H17BO3 | 100g
2-Formylphenylboronic acid pinacol ester | ≥97% | CAS 380151-85-9 | C13H17BO3 | 100g