Piperidines
Apexbio Technology LLC AZ 10606120 dihydrochloride 607378-18-7 50mg
AZ 10606120 dihydrochloride (CAS 607378-18-7) is a potent antagonist of the P2X7 receptor an ATP-gated ion channel implicated in mediating a variety of cellular responses It exhibits high binding affinity for human and rat P2X7 receptors with Kd values of 1 4 nM and 1 9 nM respectively In vitro studies demonstrate that AZ 10606120 binds reversibly and saturably to the P2X7 receptor with ligand modulation indicating both positive and negative cooperativity In vivo intratumoral injection of AZ 10606120 in murine models significantly suppressed tumor growth and reduced angiogenesis This compound is utilized as a molecular tool to investigate P2X7 receptor function in cellular signaling and tumor biology and remains in preclinical development
Medchemexpress LLC HY-40354 200mg Medchemexpress, Tofacitinib CAS:477600-75-2 Purity:>98%
Medchemexpress, HY-40354 200mg Tofacitinib CAS:477600-75-2 Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-100039 5mg Medchemexpress, YYA-021 CAS:144217-65-2 Purity:>98%
Medchemexpress, HY-100039 5mg YYA-021 CAS:144217-65-2 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC K-Ras-PDE -IN-1 | 10MG
K-Ras-PDE -IN-1 is a novel and potent competitive K-Ras-PDE inhibitor K-Ras-PDE -IN-1 binds to the farnesyl binding pocket of PDE with a low nanomolar Kd of 8 nM[1]
Medchemexpress LLC Btk inhibitor 2 (BGB-3111 analog) | 1558036-85-3 | MFCD31382019 | 99.6% | 431.49 g/mol | C24H25N5O3 | 25 MG
Btk inhibitor 2 (BGB-3111 analog) is a small-molecule inhibitor of Bruton's tyrosine kinase (BTK) described in patent US 20170224688 A1. It is supplied as a research reagent with reported high purity and is intended for in vitro biochemical and cellular studies.
- Bruton's tyrosine kinase inhibitor for research use only.
- Extracted from patent US 20170224688 A1.
- Cas number 1558036-85-3.
- Molecular formula C24H25N5O3.
- Molecular weight 431.49 g/mol.
- Reported purity 99.6%.
- Available in small research pack sizes, including 25 mg.
![Medchemexpress LLC 3-(1-(4-chlorophenyl)-4-((1H-pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin-1-yl)propan-1-ol hydrochloride | 2453324-32-6 | MFCD13177916 | 99.0% | 378.30 g·mol⁻¹ | C18H21Cl2N5 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000262961.png-250.jpg)
Medchemexpress LLC 3-(1-(4-chlorophenyl)-4-((1H-pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin-1-yl)propan-1-ol hydrochloride | 2453324-32-6 | MFCD13177916 | 99.0% | 378.30 g·mol⁻¹ | C18H21Cl2N5 | 5 MG
CCT128930 hydrochloride is the hydrochloride salt of a potent and selective AKT (protein kinase B) inhibitor for preclinical research. Supplied as a solid, it is intended for biochemical and cellular studies where high potency and defined physicochemical properties are required.
- Potent and selective AKT inhibitor (AKT IC50 ≈ 6 nM).
- Hydrochloride salt; solid, white to yellow.
- High purity (≈99.0%).
- Molecular formula C18H21Cl2N5; molecular weight 378.30 g·mol⁻¹.
- Soluble in DMSO up to 20 mg/mL with warming and sonication.
- Recommended storage sealed, away from moisture; in solution -80°C (≤6 months).
- Supplied in small research quantities suitable for assay development.
![eMolecules 637301-16-7 | 1-boc-3-azabicyclo[3.2.1]octane-8-methanol | MFCD22566234 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502157984.JPG-250.jpg)
eMolecules 637301-16-7 | 1-boc-3-azabicyclo[3.2.1]octane-8-methanol | MFCD22566234 | 1g
Pharmablock | 1-boc-3-azabicyclo[3.2.1]octane-8-methanol | 1g | 551134382 | PBN20120314 | 637301-16-7 | MFCD22566234 | 241.331 | C13H23NO3
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eMolecules 184637-48-7 | 1-Boc-3-aminopiperidine | Combi-Blocks | MFCD01861219 | 200.282 | C10H20N2O2 | 97.000 | CC(C)(C)OC(=O)N1CCCC(N)C1 | 25g | 117518457
1-Boc-3-aminopiperidine | Combi-Blocks | 184637-48-7 | MFCD01861219 | 200.282 | C10H20N2O2 | 97.000 | CC(C)(C)OC(=O)N1CCCC(N)C1 | 25g | 117518457
Medchemexpress LLC Migoprotafib (GDC-1971) | 2377352-49-1 | 98.8% | 454.53 g·mol⁻1 | C25H26N8O | 5 MG
Migoprotafib (GDC-1971) is an orally bioavailable, allosteric inhibitor of the protein tyrosine phosphatase SHP2 that inhibits the MAPK/ERK signaling pathway and has demonstrated antitumor activity in preclinical models. Supplied as a high-purity research reagent for laboratory studies.
- Allosteric SHP2 inhibition with demonstrated cellular activity.
- Inhibits MAPK/ERK signaling relevant to tumor growth.
- Orally bioavailable in in vivo studies, suitable for pharmacology research.
- High purity suitable for research applications (98.8%).
- Available in small-mass quantities for compound screening and dosing studies.
eMolecules 1003021-05-3 | (5S)-5-aminopiperidin-2-one;dihydrochloride | 1g
Medchem Express | MX69 | 5mg | 446256267 | HY-100892 | 1005264-47-0 | MFCD24858136 | 474.580 | C27H26N2O4S
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Medchemexpress LLC CCT128930 hydrochloride | 2453324-32-6 | 99.0% | C18H21Cl2N5 | 10MG
CCT128930 hydrochloride is the hydrochloride salt of a selective ATP-competitive AKT inhibitor supplied as a powder for research use. It is employed in cellular assays to probe PI3K/Akt/mTOR signaling, induce cell cycle arrest, and study autophagy; handle and store according to the product SDS and COA.
eMolecules 87120-72-7 | 4-Aminopiperidine-1-carboxylic acid tert-butyl ester | Oakwood Chemicals | MFCD01076201 | 200.282 | C10H20N2O2 | 97.000 | CC(C)(C)OC(=O)N1CCC(N)CC1 | 25g | 480116199
4-Aminopiperidine-1-carboxylic acid tert-butyl ester | Oakwood Chemicals | 87120-72-7 | MFCD01076201 | 200.282 | C10H20N2O2 | 97.000 | CC(C)(C)OC(=O)N1CCC(N)CC1 | 25g | 480116199
Medchemexpress LLC Migoprotafib (GDC-1971) | 2377352-49-1 | 98.8% | C25H26N8O | 10MG
Migoprotafib (GDC-1971) is a small-molecule SHP2 inhibitor used in preclinical research to inhibit the MAPK/ERK signaling pathway and evaluate antitumor activity. It is supplied as a light yellow solid with high reported purity and is available in multiple solid pack sizes and as a DMSO solution suitable for biochemical and cell-based assays.
- SHP2 inhibitor that modulates the MAPK/ERK signaling pathway.
- High reported purity, 98.8%.
- Light yellow to yellow solid appearance.
- Available as multiple solid pack sizes and as a 10 mM DMSO solution for assays.
- Molecular formula C25H26N8O; molecular weight 454.53 g·mol⁻¹.
- SMILES provided for cheminformatics applications.
Medchemexpress LLC HY-18373 5mg Medchemexpress, UNC1079 CAS:1418741-86-2 Purity:>98%
Medchemexpress, HY-18373 5mg UNC1079 CAS:1418741-86-2 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![eMolecules 1093651-96-7 | (2S,4R)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID | AstaTech | MFCD06656464 | 413.473 | C26H23NO4 | 95.000 | OC(=O)[C@@H]1C[C@@H](CN1C(=O)OCC1c2ccccc2-c2ccccc12)c1ccccc1 | 0.25g | 386073488](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000169786.jpg-250.jpg)
eMolecules 1093651-96-7 | (2S,4R)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID | AstaTech | MFCD06656464 | 413.473 | C26H23NO4 | 95.000 | OC(=O)[C@@H]1C[C@@H](CN1C(=O)OCC1c2ccccc2-c2ccccc12)c1ccccc1 | 0.25g | 386073488
(2S,4R)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID | AstaTech | 1093651-96-7 | MFCD06656464 | 413.473 | C26H23NO4 | 95.000 | OC(=O)[C@@H]1C[C@@H](CN1C(=O)OCC1c2ccccc2-c2ccccc12)c1ccccc1 | 0.25g | 386073488