Piperidines
Selleck Chemical LLC Donepezil HCl S2462-200mg
Donepezil HCl is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8 12 nM and 11 6 nM respectively This product is not soluble in PBS solution Please do not dissolve it in PBS for administration
Medchemexpress LLC HY-111594 10mg Medchemexpress, Homo-PROTAC cereblon degrader 1 CAS:2244520-98-5 Purity:>98%
Medchemexpress, HY-111641 50mg 3'-Azido-3'-deoxy-5-fluorocytidine CAS:2095417-18-6 3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC BSJ-4-116 | 2519823-34-6 | 99.9% | 837.38 | 50 MG
BSJ-4-116 is a PROTAC (proteolysis-targeting chimera) designed to selectively degrade CDK12 (Cyclin-Dependent Kinase 12) with high potency, evidenced by an IC50 of 6 nM. It achieves its effect by linking ligands for Cereblon and CDK, leading to the downregulation of DNA damage response (DDR) genes through premature transcriptional termination and increased poly(adenylation). This compound exhibits significant antiproliferative capabilities, both as a standalone agent and in combination with the PARP inhibitor Olaparib. It has been shown to decrease CDK12 protein levels regardless of the cell line's mutational status and can overcome resistance due to specific CDK12 mutations.
- Highly potent and selective CDK12 degrader
- Downregulates DNA damage response genes
- Exhibits antiproliferative effects
- Can overcome resistance from specific CDK12 mutations