Piperidines
Medchemexpress LLC Piperine | 94-62-2 | 99.0% | 285.34 | 10 MM * 1 ML
Piperine is an alkaloid isolated from pepper, which inhibits the activity of P-glycoprotein and CYP3A4. It has demonstrated in vitro cytotoxic activity and immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties. It can enhance the bioavailability of other drugs.
- Inhibits activity of P-glycoprotein and CYP3A4
- Exhibits in vitro cytotoxic activity
- Possesses immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties
- Enhances bioavailability of other drugs
- Inhibits phosphorylation of I-κB, p65, p38, ERK, and JNK
Medchemexpress LLC GDC-0276 10mg | 1494581-70-2 | 10 MG
GDC-0276 is a small-molecule NaV1.7 (voltage-gated sodium channel 1.7) inhibitor supplied as a solid white to off-white powder for research use only. It is provided with supporting documentation including a datasheet, COA, and SDS.
- High purity 99.69%
- Molecular formula C24H31FN2O4S
- Molecular weight 462.58
- Physical form solid, white to off-white
- Supplied as a 10 mg vial
- For research use only; not for human or diagnostic use
Medchemexpress LLC BJE6-106 (B106) | 1564249-38-2 | 99.9% | 381.47 | C26H23NO2 | 10 MG
BJE6-106 (B106) is a selective protein kinase C delta (PKCδ) inhibitor supplied as a high-purity solid for research use. It induces caspase-dependent apoptosis, activates the MKK4-JNK-H2AX pathway, and shows potent activity against PKCδ with substantially lower activity versus PKCα.
- Selective PKCδ inhibition with IC50 0.05 μM.
- Induces caspase-dependent apoptosis and tumor-specific effects.
- Activates the MKK4-JNK-H2AX signaling pathway.
- High purity solid (99.85%) suitable for biochemical and cell-based assays.
- Molecular formula C26H23NO2 and molecular weight 381.47.
Medchemexpress LLC 1-Boc-2-piperidone | 85908-96-9 | >=98.0% | 199.25 | 10 G
1-Boc-2-piperidone is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It appears as a solid, ranging from white to light brown.
- Molecular weight of 199.25
- Purity of 98.0%
- Store powder at -20°C for 3 years, or 4°C for 2 years
- Solubility in DMSO is 200 mg/mL
Cambridge Isotope Laboratories Pipecolic acid (piperidine 2-carboxylic acid) (13C6 98% 15N 98%) 10 mg
Pipecolic acid (piperidine 2-carboxylic acid) (13C6 98% 15N 98%) 10 mg
Medchemexpress LLC Piperidin-2-one | 675-20-7 | 99.9% | 99.13 g/mol | C5H9NO | 10 G
2-Piperidone (piperidin-2-one; δ-valerolactam) is an endogenous metabolite and a biomarker for CYP2E1 activity. It is supplied as a high-purity research standard for use in analytical, metabolic, and pharmacological studies. CAS number 675-20-7; molecular formula C5H9NO; molecular weight 99.13 g/mol; purity 99.89%.
- high-purity research-grade material suitable for analytical assays and reference standards.
- soluble in DMSO and water at high concentrations with ultrasonic aid.
- provided in multiple pack sizes to support small-scale and bulk experiments.
- storage recommendations available for long-term stability in solid and solvent forms.
Medchemexpress LLC 2-((2S,6S)-2-phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone | 1009583-20-3 | 99.9% | 341.44 g/mol | C21H27NO3 | 10 MG
BMS-816336 is a potent, orally bioavailable small-molecule inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with an IC50 of 3.0 nM. It is provided for research use and is characterized by a defined molecular formula and molecular weight, with storage recommendations for powder and solutions.
- Potent inhibitor of human 11β-HSD1 with IC50 3.0 nM.
- Orally bioavailable small molecule suitable for pharmacology studies.
- Molecular formula C21H27NO3 and molecular weight 341.44 g/mol.
- High purity (99.9%) for reliable experimental results.
- Recommended storage: powder -20°C (long term) and solvent -80°C for stability.
![Medchemexpress LLC 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid | 1152782-19-8 | 99.7% | 392.37 g·mol⁻¹ | C20H19F3N2O3 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241312.png-250.jpg)
Medchemexpress LLC 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid | 1152782-19-8 | 99.7% | 392.37 g·mol⁻¹ | C20H19F3N2O3 | 10 MG
A 1120 (CAS 1152782-19-8) is a high-affinity, nonretinoid antagonist of retinol-binding protein 4 (RBP4) used in preclinical research to modulate the visual cycle and reduce retinal lipofuscin accumulation. It disrupts RBP4 binding to transthyretin, lowers circulating RBP4 and visual-cycle retinoids in animal studies, and has been characterized in structural and pharmacology literature.
- High-affinity RBP4 antagonist with reported Ki ≈ 8.3 nM.
- Disrupts RBP4-transthyretin interaction in vitro.
- Reduces serum RBP4 and visual-cycle retinoids in preclinical models.
- Decreases retinal lipofuscin bisretinoid accumulation in animal studies.
- High reported purity (~99.7%) suitable for research use.
- Molecular formula C20H19F3N2O3; molecular weight ~392.4 g·mol⁻¹.
TARGETMOL CHEMICALS INC NELFINAVIR MESYLATE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Nelfinavir Mesylate (Viracept) is an effective HIV protease inhibitor (Ki 2 nM). purity: 98%
TARGETMOL CHEMICALS INC AVIBACTAM SODIUM 50MG
Also available in 2 mg 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Avibactam sodium (NXL-104) is a reversible (beta)-lactamase inhibitor (IC50 8/80/38 nM for TEM-1/P99/KPC-2 (beta)-lactamases). purity: 99%
TARGETMOL CHEMICALS INC PIPERIDINE-MO-1 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Piperidine-MO-1 is a dopamine receptor modulator with an ED50 of 68 uMol/kg on increase of DOPAC in the rat striatum (WO/2005/121087A1 compound example 2). purity: 97%
TARGETMOL CHEMICALS INC KARTOGENIN 50MG
Also available in 2 mg 5 mg 10 mg 25 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Kartogenin (KGN) is an activator of the smad4/smad5 pathway and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. purity: 96%
TARGETMOL CHEMICALS INC ANAMORELIN HYDROCHLORIDE 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 0.74 nM in the FLIPR assay). purity: 99%
Selleck Chemical LLC AT7519 HCl 5mg 902135-91-5
AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Iowh-032 | 1191252-49-9 | 99.6% | 545.18 | 100 MG
IOWH-032 is a synthetic anti-secretory molecule and a potent CFTR inhibitor with an IC50 value of 8 μM. It also functions as an anti-diarrheal agent. This product is for research use only.
- Potent CFTR inhibitor with an IC50 of 8 μM
- Anti-diarrheal agent
- Increases ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells at 10 μM
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