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Organic heterocyclic compounds that consist of a six-membered ring containing five carbon atoms and one nitrogen atom that forms an amine functional group.
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Avibactam free acid, also known as NXL-104 free acid, is a potent covalent and reversible non-β-lactam β-lactamase inhibitor. It demonstrates strong inhibitory activity against β-lactamase TEM-1 and CTX-M-15, with IC50 values of 8 nM and 5 nM, respectively. This compound exhibits minimal antibacterial activity on its own but is effective in inhibiting Class A and C β-lactamases. It does not inhibit metallo β-lactamases or Acinetobacter OXA carbapenemases.
Broad-spectrum β-lactamase inhibition
Synergistic activity
In vivo efficacy
Research applications
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