Pyrans
Apexbio Technology LLC Octyl-α-ketoglutarate 876150-14-0 10mg (solution)
Octyl- -ketoglutarate is a membrane-permeable derivative of -ketoglutarate a substrate required for prolyl hydroxylases (PHDs) enzymes regulating the stability of hypoxia-inducible factor-1 (HIF-1 ) through oxygen-dependent hydroxylation Intracellular delivery by octyl conjugation enhances cellular -ketoglutarate availability enabling the restoration of PHD enzymatic function compromised by elevated succinate or fumarate Research indicates its utility in cellular models with impaired TCA-cycle enzymes such as IDH1 mutations facilitating the study of hypoxic signaling pathways and tumor cell pseudohypoxia responses
FUJIFILM BIOSCIENCES INC Y-27632 MF
Y-27632 is reagent for cell culture applications including human ES/iPS cell culture It is a selective and potent inhibitor of ROCK Rho-associated coiled-coil forming kinase/Rho binding kinase Y-27632 has a variety of activities including vascular smooth muscle contraction through the ROCK signaling Ki 140 nmol/L p160ROCK This product has been reported to suppress death of human ES cells and human iPS cells at the time of cell dispersion and also improve viability of the cells after cryopreservation
Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 g/mol | C37H35F3N10O9 | 5 MG
Carboxy pyridostatin (trifluoroacetate salt) is a research-grade G-quadruplex ligand supplied as a solid salt for in vitro and in vivo studies. It selectively recognizes RNA on DNA G-quadruplex structures, reduces ATF-5 protein levels, inhibits cell proliferation, and impairs stress granule formation.
- Cas number: 2444713-88-4.
- Molecular formula: C37H35F3N10O9.
- Molecular weight: 820.73 g/mol.
- Purity: 99.5%.
- Pack sizes include 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.
- Soluble in DMSO at 50 mg/mL with ultrasonic warming to 60°C.
- In vivo formulations achievable at ≥2.5 mg/mL in common vehicle mixtures.
- Storage: solid sealed away from moisture, recommended -20°C; in solution -80°C (6 months), -20°C (1 month).