Pyridines and derivatives
Medchemexpress LLC Dimethylcurcumin | 52328-98-0 | C23H24O6 | 25 MG
Dimethylcurcumin is an analytical standard intended for research and analytical applications. It acts as an androgen receptor degradation enhancer, effectively suppressing castration-resistant prostate cancer cell proliferation and invasion.
- Analytical standard for research
- Used in analytical applications
- Androgen receptor degradation enhancer
- Suppresses castration-resistant prostate cancer cell proliferation
- Suppresses castration-resistant prostate cancer cell invasion
Medchemexpress LLC Dimethylcurcumin | 52328-98-0 | C23H24O6 | 100 MG
Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer that effectively suppresses castration-resistant prostate cancer cell proliferation and invasion. It works by selectively promoting AR degradation by disrupting the interaction between AR and AR coregulators, and it reduces the aggregation of AR-112Q in cells.
- Enhances androgen receptor degradation
- Suppresses castration-resistant prostate cancer cell proliferation and invasion
- Promotes AR degradation by disrupting interaction between AR and AR coregulators
- Reduces aggregation of AR-112Q in cells
- High purity (98.01%)
- Molecular weight of 396.43
- Solid appearance
- Yellow to orange color
- Soluble in DMSO (≥ 50 mg/mL)
- Suitable for in vivo preparation
Medchemexpress LLC Oxaloacetate decarboxylase | 9024-98-0 | 1 KU
Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and COIC2. It is a member of the sodium ion transport decarboxylase (NaT-DC) enzyme family and converts the chemical energy of the decarboxylation reaction into an electrochemical gradient of Na+ ions across the membrane.
- Catalyzes irreversible decarboxylation of oxaloacetate to pyruvate and COIC2
- Member of the sodium ion transport decarboxylase (NaT-DC) enzyme family
- Converts chemical energy of decarboxylation reaction into an electrochemical gradient of Na+ ions
Medchemexpress LLC Lepidiline A | 596093-98-0 | 99.5% | 50 MG
Lepidiline A is a natural product, appearing as a white to off-white solid. It exhibits cytotoxic activity against HL-60 cells and targets 17β-HSD activity, enhancing sex hormone bioconversion. This product is intended for research use only, not for medical applications.
- Exhibits cytotoxic activity against HL-60 cells with an IC50 value of 32.3 μM.
- Targets HSD17B1 activity.
- Increases the bioconversion efficiency of sex hormones.
- Improves the reproductive capacity of fruit flies.
- Supplied as a solid with a white to off-white appearance.
- For research use only.
Medchemexpress LLC Dalmelitinib | 1637658-98-0 | 98.7% | 461.47 | 50 MG
Dalmelitinib is an orally active selective c-Met kinase inhibitor that binds to the ATP-binding region of c-Met. It potently inhibits the proliferation of cancer cells with c-Met oncogene amplification and is used for research in cancers such as human non-small cell lung cancer (NSCLC).
- Orally active selective c-Met kinase inhibitor
- Binds to the ATP-binding region of c-Met
- Induces phosphorylation of MET
- Partially or completely inhibits phosphorylation of AKT and ERK
- Potently inhibits cancer cell proliferation (c-Met oncogene amplification)
- Used for research of human non-small cell lung cancer (NSCLC)
Medchemexpress LLC D-3 | 1967815-98-0 | 99.49% | 10 MG
D-3 is a phosphorpeptide acting as an efficient and specific iPSC-eliminating agent. It prevents iPSC-induced teratoma formation and significantly reduces iPSC viability, with minimal effects on non-iPSCs such as hepatocytes and neurons.
- Efficient and specific iPSC-eliminating agent.
- Prevents iPSC-induced teratoma formation.
- Induces viability loss in 201B7 cells (IC50 of 192.3 ± 57.4 μM).
- Activates eIF2a, p38, and p44/42 MAPK, indicating cellular stress.
- Increases apoptotic and dead cells (Annexin-V and SYTOX-positive).
- Minimal impact on non-iPSCs (hepatocytes, neurons).
- 400 μM for 1-2 hours induces >99% viability loss in human iPSC lines and >95% in human ESC line khES1.
Medchemexpress LLC D-3 | 1967815-98-0 | 99.5% | 5 MG
D-3 is a phosphorpeptide that acts as an efficient, simple, and specific iPSC-eliminating agent. It is intended for research use only. It prevents residual iPSC-induced teratoma formation in a mouse tumorigenicity assay and induces a significant loss of viability in 201B7 cells with a half-maximal inhibitory concentration of 192.3 ± 57.4 μM.
- Acts as an efficient, simple, and specific iPSC-eliminating agent.
- Prevents residual iPSC-induced teratoma formation in a mouse tumorigenicity assay.
- Induces significant loss of viability in 201B7 cells.
- Activates eIF2a, p38, and p44/42 MAPK, which are pathways responsive to cellular stress.
- Increases the number of apoptotic and dead cells.
- Has minimal effects on various non-iPSCs, such as hepatocytes and neurons.
Medchemexpress LLC Oxaloacetate decarboxylase | 9024-98-0 | 500 U
Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and CO₂. It is a member of the sodium ion transport decarboxylase (NaT-DC) enzyme family.
- Converts the chemical energy of the decarboxylation reaction into an electrochemical gradient of Na⁺ ions across the membrane.
- For research use only.
Medchemexpress LLC Anguizole | 442666-98-0 | 99.5% | C17H11ClF2N4O2S | 10MG
Anguizole is a small-molecule inhibitor of hepatitis C virus (HCV) replication that alters NS4B subcellular distribution. Supplied as a light yellow solid for laboratory research, it offers high purity and documented storage stability for biochemical and cell-based studies.
- Inhibits HCV replication and alters NS4B localization.
- High purity (99.5%) suitable for biochemical and cell-based assays.
- Molecular formula C17H11ClF2N4O2S; molecular weight 408.81.
- Available in multiple pack sizes for flexible experiment planning.
- Stable when stored as powder at -20°C; solvent stability documented.
Medchemexpress LLC Oxaloacetate decarboxylase | 9024-98-0 | 5 KU
Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and COIC2. This enzyme belongs to the sodium ion transport decarboxylase (NaT-DC) enzyme family and converts the chemical energy from the decarboxylation reaction into an electrochemical gradient of Na+ ions across the membrane.
- Catalyzes irreversible decarboxylation of oxaloacetate to pyruvate and COIC2.
- Member of the sodium ion transport decarboxylase (NaT-DC) enzyme family.
- Converts chemical energy of decarboxylation into an electrochemical gradient of Na+ ions.
- Available in various sizes: 500 U, 1 KU, 5 KU.
- For research use only.
Medchemexpress LLC Lepidiline A | 596093-98-0 | >99.5% | 100 MG
Lepidiline A demonstrates cytotoxic activity against HL-60 cells with an IC50 value of 32.3 μM. It targets HSD17B1 activity, enhancing the bioconversion efficiency of sex hormones, including the conversion of estrogen to 17β-estradiol and 4-androsten-3,7-dione to testosterone. This action contributes to improved reproductive capacity in fruit flies.
- Targets HSD17B1 activity
- Enhances sex hormone bioconversion efficiency
- Improves reproductive capacity in fruit flies
Medchemexpress LLC Lepidiline A | 596093-98-0 | 99.54% | 10 MG
Lepidiline A exhibits cytotoxic activity against HL-60 cells with an IC50 value of 32.3 μM. It targets HSD17B1 activity, increasing the bioconversion efficiency of sex hormones (including the conversion of estrogen into 17β-estradiol and 4-androsten-3,7-dione into testosterone), which in turn improves the reproductive capacity of fruit flies.
- Targets HSD17B1 activity
- Enhances sex hormone bioconversion
- Exhibits cytotoxic activity against HL-60 cells
- Stable as powder at -20°C for 3 years
- Stable in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Ammonium lactate | 515-98-0 | 60% | 100 G
Ammonium lactate is the ammonium salt of lactic acid, possessing mild anti-bacterial properties. It can be utilized in the research of xerosis.
- Mild anti-bacterial properties
- Can be used for the research of xerosis
- May be useful in mitigating the adverse effects of corticosteroid on skin
Medchemexpress LLC Ammonium lactate | 515-98-0 | 60.0% | 25 G
Ammonium lactate is the ammonium salt of lactic acid. It possesses mild anti-bacterial properties and can be utilized in research pertaining to xerosis.
- Mild anti-bacterial properties.
- Suitable for xerosis research.
- Presented as a colorless to light yellow liquid.
- Recommended storage at -20°C for 2 years as a solution.
- Soluble in water at 116.67 mg/mL.
Medchemexpress LLC Dalmelitinib | 1637658-98-0 | 98.7% | 461.47 | 25 MG
Dalmelitinib is an orally active, selective c-Met kinase inhibitor that binds to the ATP-binding region of c-Met. It induces MET phosphorylation and inhibits AKT and ERK phosphorylation. Dalmelitinib potently inhibits cancer cell proliferation and is used in research for cancers such as human non-small cell lung cancer (NSCLC).
- Orally active selective c-Met kinase inhibitor
- Binds to the ATP-binding region of c-Met
- Induces phosphorylation of MET
- Inhibits phosphorylation of AKT and ERK
- Potently inhibits cancer cell proliferation
- Used for research of human non-small cell lung cancer