Pyridines and derivatives
Apexbio Technology LLC VX-11e 896720-20-0 100mg
VX-11e (CAS 896720-20-0) is a potent and selective inhibitor of extracellular signal-regulated kinase (ERK) a critical serine/threonine kinase within the Ras/Raf/MEK/ERK signaling cascade This pathway is frequently dysregulated in various human cancers and is implicated in mediating oncogenic proliferation and survival signals By directly inhibiting ERK activity VX-11e enables the investigation of ERK-dependent cellular processes and supports the exploration of targeted therapeutic strategies in cancer research
Apexbio Technology LLC VX-11e 896720-20-0 50mg
VX-11e (CAS 896720-20-0) is a potent and selective inhibitor of extracellular signal-regulated kinase (ERK) a critical serine/threonine kinase within the Ras/Raf/MEK/ERK signaling cascade This pathway is frequently dysregulated in various human cancers and is implicated in mediating oncogenic proliferation and survival signals By directly inhibiting ERK activity VX-11e enables the investigation of ERK-dependent cellular processes and supports the exploration of targeted therapeutic strategies in cancer research
Apexbio Technology LLC ATB-346 1226895-20-0 100mg
ATB-346 (CAS 1226895-20-0) is a hydrogen sulfide-releasing derivative of the nonsteroidal anti-inflammatory drug (NSAID) naproxen It exerts anti-inflammatory effects by inhibiting prostaglandin E2 (PGE2) levels and fully suppressing whole blood thromboxane B2 (TXB2) synthesis In preclinical models ATB-346 significantly reduced paw swelling in rats with adjuvant-induced arthritis when administered on days 14 and 21 Notably it produced minimal gastrointestinal damage relative to naproxen which induced substantial intestinal injury under similar dosing conditions ATB-346 is thus a valuable tool for investigating hydrogen sulfide-mediated anti-inflammatory mechanisms and NSAID-induced gastrointestinal safety
Apexbio Technology LLC ATB-346 1226895-20-0 50mg
ATB-346 (CAS 1226895-20-0) is a hydrogen sulfide-releasing derivative of the nonsteroidal anti-inflammatory drug (NSAID) naproxen It exerts anti-inflammatory effects by inhibiting prostaglandin E2 (PGE2) levels and fully suppressing whole blood thromboxane B2 (TXB2) synthesis In preclinical models ATB-346 significantly reduced paw swelling in rats with adjuvant-induced arthritis when administered on days 14 and 21 Notably it produced minimal gastrointestinal damage relative to naproxen which induced substantial intestinal injury under similar dosing conditions ATB-346 is thus a valuable tool for investigating hydrogen sulfide-mediated anti-inflammatory mechanisms and NSAID-induced gastrointestinal safety
Apexbio Technology LLC ATB-346 1226895-20-0 10mg
ATB-346 (CAS 1226895-20-0) is a hydrogen sulfide-releasing derivative of the nonsteroidal anti-inflammatory drug (NSAID) naproxen It exerts anti-inflammatory effects by inhibiting prostaglandin E2 (PGE2) levels and fully suppressing whole blood thromboxane B2 (TXB2) synthesis In preclinical models ATB-346 significantly reduced paw swelling in rats with adjuvant-induced arthritis when administered on days 14 and 21 Notably it produced minimal gastrointestinal damage relative to naproxen which induced substantial intestinal injury under similar dosing conditions ATB-346 is thus a valuable tool for investigating hydrogen sulfide-mediated anti-inflammatory mechanisms and NSAID-induced gastrointestinal safety
Apexbio Technology LLC Cediranib (AZD217) 288383-20-0 100mg
Cediranib (AZD2171 CAS 288383-20-0) is an orally bioavailable small molecule inhibitor targeting the kinase insert domain receptor (KDR VEGFR-2) with potent inhibition observed in recombinant assays (IC50 1 nM) Additionally cediranib suppresses related vascular endothelial growth factor receptors VEGFR-1 (Flt-1 IC50 5 nM) and VEGFR-3 (Flt-4 IC50 3 nM) It also blocks select platelet-derived growth factor receptors notably c-Kit PDGFR PDGFR and CSF-1R at nanomolar to sub-micromolar concentrations indicating multiple-kinase targeting capability Cediranib serves as a valuable research compound for studying tumor angiogenesis and kinase-driven oncogenic pathways
Medchemexpress LLC Otenaproxesul | 1226895-20-0 | C21H19NO3S | 25 MG
Otenaproxesul | 1226895-20-0 | C21H19NO3S | 25 MG
Medchemexpress LLC Otenaproxesul | 1226895-20-0 | C21H19NO3S | 1 ML
Otenaproxesul is a chemical compound identified by CAS number 1226895-20-0 and chemical formula C21H19NO3S. It is supplied as a light yellow to yellow solid with a high purity of 98.03%. This product is intended for laboratory use in research and manufacturing of substances, and it has not been validated for medical applications.
- Chemical name: 2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, 4-(aminothioxomethyl)phenyl ester
- Molecular weight: 365.45
- Appearance: Light yellow to yellow solid
- Purity (HPLC): 98.03%
- Recommended storage for powder: -20°C for 3 years, 4°C for 2 years
- Recommended storage in solvent: -80°C for 2 years, -20°C for 1 year
- Identified uses: Laboratory chemicals, manufacture of substances
- For research use only
Medchemexpress LLC Otenaproxesul | 1226895-20-0 | C21H19NO3S | 50 MG
Otenaproxesul (ATB-346) is a laboratory chemical primarily intended for research use only. This solid substance is classified as hazardous, causing skin irritation, serious eye irritation, and potential respiratory tract irritation, requiring handling by qualified personnel in appropriate facilities.
- Research-grade laboratory chemical
- Solid appearance
- Stable under recommended storage conditions
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
- Recommended storage for powder: -20°C for 3 years, 4°C for 2 years
- Recommended storage for in solvent: -80°C for 2 years, -20°C for 1 year
Apexbio Technology LLC VX-11e 896720-20-0 10mg
VX-11e (CAS 896720-20-0) is a potent and selective inhibitor of extracellular signal-regulated kinase (ERK) a critical serine/threonine kinase within the Ras/Raf/MEK/ERK signaling cascade This pathway is frequently dysregulated in various human cancers and is implicated in mediating oncogenic proliferation and survival signals By directly inhibiting ERK activity VX-11e enables the investigation of ERK-dependent cellular processes and supports the exploration of targeted therapeutic strategies in cancer research
Medchemexpress LLC Smip34 | 1189710-20-0 | 90.0% | 10 MG
SMIP34 is a small-molecule PELP1 inhibitor used in cancer research to inhibit cell proliferation and tumor progression. It is provided as a white to off-white solid in small research quantities, suitable for in vitro studies of breast and endometrial cancer.
- PELP1 inhibitor that reduces cell viability and colony formation.
- Binds PELP1 with a Kd of 37.4 μM.
- CAS number 1189710-20-0 for unambiguous identification.
- Molecular formula C25H32ClN5O3 and molecular weight 486.01 g/mol.
- Purity approximately 90.0% as supplied.
- White to off-white solid suitable for research use.
- Store at -20°C, protect from light, and handle under inert atmosphere when required.
Medchemexpress LLC Otenaproxesul | 1226895-20-0 | C21H19NO3S | 100 MG
Otenaproxesul (ATB-346) is an orally active non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase-1 and 2 (COX-1 and 2). It exhibits anti-inflammatory and antinociceptive activities.
- Inhibits cyclooxygenase-1 and 2 (COX-1 and 2)
- Exhibits anti-inflammatory properties
- Shows antinociceptive activities
- Reduces gastrointestinal toxicity
- Inhibits human melanoma cell proliferation
- Induces apoptosis of human melanoma cells
- Inhibits melanoma tumor growth in vivo
- Suppresses PGE2 levels and TXB2 synthesis
- Reduces paw oedema
Medchemexpress LLC Otenaproxesul | 1226895-20-0 | CB52627347 | C21H19NO3S | 5 MG
Otenaproxesul is an orally active non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase-1 and 2 (COX-1 and 2). It possesses anti-inflammatory and antinociceptive activities, exhibiting properties similar to naproxen but with substantially reduced gastrointestinal toxicity.
- Inhibits cyclooxygenase-1 and 2
- Possesses anti-inflammatory and antinociceptive activities
- Reduced gastrointestinal toxicity
- Inhibits human melanoma cell proliferation
- Induces apoptosis of human melanoma cells
- Inhibits bone defect and histological characteristics related to periodontitis
Medchemexpress LLC Progabide | 62666-20-0 | 98.5% | C17H16ClFN2O2 | 25 MG
Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. This compound is intended for research use only.
- Acts as a GABA receptor agonist.
- Can increase plasma corticosterone levels in rats, suitable for in vivo studies.
- High purity of 98.5%.
- Available in powder form for preparing solutions.
- Offers long-term stability with proper storage.
Medchemexpress LLC Progabide | 62666-20-0 | 98.5% | C17H16ClFN2O2 | 5 MG
Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. It has been shown to increase plasma corticosterone levels in male Wistar rats in a dose-dependent manner.
- Acts as a GABA receptor agonist.
- Increases plasma corticosterone levels in male Wistar rats.
- Molecular weight: 334.77.
- Appearance: Solid.
- Color: Light yellow to yellow.
- Soluble in DMSO (250 mg/mL).
- Store powder at -20°C for 3 years, or 4°C for 2 years.
- Store in solvent at -80°C for 6 months, or -20°C for 1 month.