Apexbio Technology LLC MJ33 LITHIUM SALT 5MG
MJ33 (lithium salt CAS 1007476-63-2 199106-13-3) is a small molecule inhibitor of the acidic calcium-independent phospholipase A2 (aiPLA2) activity of peroxiredoxin-6 (Prdx6) Prdx6 exhibits dual enzymatic functions encompassing both glutathione peroxidase and PLA2 activities It plays a role in lung surfactant lipid metabolism particularly processing dipalmitoylphosphatidylcholine MJ33 selectively suppresses aiPLA2 activity as demonstrated through inhibition of phosphorylation-stimulated recombinant and native Prdx6 in vitro Moreover MJ33 has shown protective effects in animal models attenuating ROS generation inflammatory cytokine release NF- B activation and tissue damage in LPS-induced acute lung injury highlighting its utility for inflammation-related biomedical research