Pyrimidines And Derivatives
Apexbio Technology LLC N-Acetylserotonin 1210-83-9 250mg
N-Acetylserotonin (CAS 1210-83-9) is a biochemical intermediate in the melatonin biosynthetic pathway formed via acetylation of serotonin by arylalkylamine N-acetyltransferase (AANAT) It acts as an agonist at melatonin receptors MT1 MT2 and MT3 which are G protein-coupled receptors involved in circadian regulation Distinctively N-acetylserotonin rapidly activates the TrkB receptor in vitro and in vivo in a circadian fashion independently of neurotrophins and the MT3 receptor This TrkB activation has been associated with antidepressant-like effects in animal models N-Acetylserotonin is thus valuable for research on neurotrophic signaling circadian biology and the molecular mechanisms underlying mood regulation
Apexbio Technology LLC Thiamine HCl (Vitamin B1) 67-03-8 10mM (in 1mL H20)
Thiamine HCl (Vitamin B1) (67-03-8) is a water-soluble micronutrient and biological precursor involved in coenzyme-dependent metabolic pathways It undergoes phosphorylation in cells to form thiamine pyrophosphate (TPP) which participates in carbohydrate metabolism through enzymatic reactions involving pyruvate dehydrogenase alpha-ketoglutarate dehydrogenase and branched-chain alpha-keto acid dehydrogenase complexes Thiamine HCl exerts its biological activity primarily through serving as a precursor to the coenzyme TPP enabling regulation of carbohydrate metabolic pathways In vitro assays frequently apply thiamine HCl to investigate enzyme activity regulation and coenzyme-dependent processes however clearly reported IC50 values are not specified due to its principal function as a coenzyme precursor Based on these attributes thiamine HCl holds research potential in studies of cellular energetics neuronal function and metabolic processes
Apexbio Technology LLC Terazosin HCl 70024-40-7 250mg
Terazosin hydrochloride (CAS 70024-40-7) is a selective antagonist of alpha1-adrenergic receptors By inhibiting these receptors terazosin induces relaxation of smooth muscle in the prostate and bladder neck thereby reducing urinary outflow resistance It is widely utilized in biomedical research to study the modulation of alpha1-adrenergic signaling pathways and the pathophysiology of lower urinary tract symptoms particularly in the context of benign prostatic hyperplasia (BPH) Its mechanism supports investigations into autonomic regulation of smooth muscle function and the pharmacological management of urological disorders
Apexbio Technology LLC HLCL-61 1158279-20-9 25mg
HLCL-61 (CAS 1158279-20-9) is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5) an enzyme implicated in the epigenetic regulation of gene expression through symmetric dimethylation of arginine residues on histones and other proteins HLCL-61 shows specificity for PRMT5 exhibiting no inhibitory activity against PRMT1 PRMT4 or other type II PRMT family members In cellular studies HLCL-61 suppresses symmetric dimethylation of histones H3 and H4 leading to reduced viability and enhanced differentiation of acute myeloid leukemia (AML) cell lines and primary blasts HLCL-61 is currently utilized in preclinical research to investigate PRMT5-mediated epigenetic mechanisms in cancer
Frontier Specialty Chemicals 1g 5-Fluorocytosine, 2022-85-7 MFCD00006035
This item has a minimum qty of 8 per supplier requirements.
5-Fluorocytosine CAS: 2022-85-7 MFCD00006035 Building Blocks Pyrimidine
Medchemexpress LLC HY-18062 500mg , Pyrimethamine Pirimecidan;Pirimetamin;RP 4753 CAS:58-14-0 Purity:98%
Medchemexpress, HY-18062 500mg Pyrimethamine Pirimecidan;Pirimetamin;RP 4753 CAS:58-14-0 Formula:C12H13ClN4 Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-19327 100mg , ACY-738 CAS:1375465-91-0 Purity:98%
Medchemexpress, HY-19327 100mg ACY-738 CAS:1375465-91-0 Formula:C14H14N4O2 IC50: 1.7 nM (HDAC6), 94 nM (HDAC1), 128 nM (HDAC2), 218 nM (HDAC3) Purity:98% ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC 50 s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC 50 s of 94, 128, and 218 nM. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Sigma Organic Chemistry 4-Methylpyrimidine | 10G | 3438-46-8 | MFCD00006115
CAS #: 3438-46-8
MDL #: MFCD00006115
Purity: >97 %
UNSPSC Code: 12352100
Molecular Weight: 94.11
Sigma Organic Chemistry 2-Mercaptopyrimidine | 10G | 1450-85-7 | MFCD00006073
CAS #: 1450-85-7
MDL #: MFCD00006073
Purity: >98 %
UNSPSC Code: 12352100
Molecular Weight: 112.15
Sigma Organic Chemistry Ethyl benzoylacetate | 100ML | 94-02-0 | MFCD00009196
CAS #: 94-02-0
MDL #: MFCD00009196
Purity: 97% (HPLC)
UNSPSC Code: 12352100
Molecular Weight: 192.21
Sigma Organic Chemistry 2 6-Dichloro-4-pyridyl | 1G | 101990-69-6 | MFCD00052638
2 6-Dichloro-4-pyridyl , 1G
About this item:
CAS #: 101990-69-6
MDL #: MFCD00052638
Chemical Formula: C6H5Cl2NO
Molecular Weight: 178.02
UNSPSC Code: 12352200
Sigma Organic Chemistry mono-Methyl glutarate | 25G | 1501-27-5 | MFCD00004409
mono-Methyl glutarate, 25G
About This Item:
Density: 1.169 g/mL at 25 C (lit.)
Refractive Index: n20/D 1.438 (lit.)
Storage: room temp
EINECS Number: 216-116-1
Sigma Organic Chemistry 5-Methyl-2-pyrrolidinon | 10G | 108-27-0 | MFCD00005273
5-Methyl-2-pyrrolidinone, 10G
About This Item:
Linear Formula: C5H9NO
Storage: 2-8C
EINECS Number: 203-566-9
Sigma Organic Chemistry 5-Methyl-2-thiophenecar | 25G | 13679-70-4 | MFCD00005434
5-Methyl-2-thiophenecarboxaldehyde, 25G
About This Item:
Density: 1.17 g/mL at 25 C (lit.)
Refractive Index: n20/D 1.583 (lit.)
Storage: 2-8C
EINECS Number: 237-178-6
Sigma Organic Chemistry 1-BenzY-N N--pyrroliDNa | 250mg | MFCD00191304
1-BenzY-N N--pyrroliDNa , 250mg
About this Item:
MDL #: MFCD00191304
Molecular Weight: 204.31
UNSPSC Code: 12352200
Chemical Formula: C13H20N2