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Filtered Search Results
Apexbio Technology LLC UC2288 1394011-91-6 250mg
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UC2288 (CAS 1394011-91-6) is a cell-permeable orally bioavailable small molecule structurally derived from sorafenib It selectively downregulates p21 expression at the mRNA level independent of p53 status resulting in reduced p21 protein levels with minimal impact on protein stability UC2288 does not inhibit VEGFR2 or kinase activity even at concentrations up to 10 M This compound is utilized in biomedical research to investigate the cellular functions of p21 and its regulatory pathways and to explore potential therapeutic strategies targeting p21-associated mechanisms
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Medchemexpress LLC 5-methyl-2-(pyrimidin-2-yl)benzoic acid | 1088994-22-2 | MFCD14706695 | 214.22 | 50 G
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5-methyl-2-(pyrimidin-2-yl)benzoic acid is a chemical intermediate primarily utilized in the synthesis of anticancer drugs. This compound is typically found as a white to off-white solid.
- White to off-white solid appearance
- Molecular formula C12H10N2O2
- Molecular weight 214.22
- Boiling point 316 °C
- Density 1.260
- Flash point 145 °C
- Heavy atoms count: 16
- Rotatable bond count: 2
- Number of rings: 2
- Polar surface area: 63 Å2
- Hydrogen bond acceptors count: 4
- Hydrogen bond donors count: 1
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Medchemexpress LLC 3-MALEIMIDYLPROPANOY 250MG
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5000205178 3-MALEIMIDYLPROPANOY 250MG
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Medchemexpress LLC Methylisothiazolinone | 2682-20-4 | MFCD01742315 | 99.5% | 115.15 | 250 MG
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Methylisothiazolinone is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. It can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone can also promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses and cause mitochondrial damage in the endothelium of rat cerebral blood vessels.
- Bacterial and fungal inhibitor
- Preservative agent
- Activates matrix metalloproteinases (MMPs)
- Promotes atopic dermatitis development in mice
- Causes mitochondrial damage in rat cerebral blood vessels endothelium
- Solid appearance, white to off-white color
- Soluble in DMSO
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Medchemexpress LLC Triallate | 2303-17-5 | 99.0% | 250 MG
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Triallate is a thiocarbamate-class pre-emergence herbicide provided as a high-purity analytical standard for research and pesticide analysis. It is supplied in a 250 mg packaged quantity and is intended for use as a reference material in residue analysis and method development.
- High purity suitable for analytical applications.
- Intended as a reference standard for pesticide residue testing.
- Solid under typical laboratory conditions (appearance: white to off-white).
- Molecular formula C10H16Cl3NOS; molecular weight 304.66 g/mol.
- Store and handle according to SDS and COA instructions.
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eMolecules 2435-50-9 | Pyrimidine-4-carboxaldehyde | Apollo Scientific | MFCD03789624 | 108.100 | C5H4N2O | 95.000 | O=Cc1ccncn1 | 1g | 562428806
Pyrimidine-4-carboxaldehyde | Apollo Scientific | 2435-50-9 | MFCD03789624 | 108.100 | C5H4N2O | 95.000 | O=Cc1ccncn1 | 1g | 562428806
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Medchemexpress LLC Chloro-1,5-cyclooctadiene iridium(I) dimer | 12112-67-3 | 671.70 | 250 MG
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This biochemical reagent is suitable for life science related research. It serves as a precursor to various iridium complexes and is applied in homogeneous catalysis for reactions including carbonylation, hydrosilylation, hydroformylation, asymmetric allylic substitutions, metatheses, and chiral catalysis. Additionally, it plays a role in preparing Crabtree's catalyst for hydrogenation and hydrogen-transfer reactions.
- Precursor to other iridium complexes
- Applied in homogeneous catalysis for reactions such as carbonylation, hydrosilylation, hydroformylation, asymmetric allylic substitutions, metatheses, and chiral catalysis
- Involved in the preparation of Crabtree's catalyst
- Used for hydrogenation and hydrogen-transfer reactions
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Medchemexpress LLC TEPP-46 (ML-265) | 1221186-53-3 | 99.9% | 372.46 | 250 MG
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TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, demonstrating minimal to no effect on PKM1, PKL, and PKR. It is intended for research use only.
- Potent and selective pyruvate kinase M2 (PKM2) activator
- AC50 of 92 nM for PKM2
- Shows minimal effect on PKM1, PKL, and PKR
- Exhibits good oral bioavailability, low clearance, and long half-life
- Achieves maximal PKM2 activation in A549 xenograft tumors
- Decreases intracellular acetyl-coA, lactate, ribose phosphate, and serine
- Inhibits LPS-induced Hif-1α and IL-1β, downregulating M1 markers
- Significantly inhibits FSL-1 and CpG-induced Il1b mRNA expression
- Inhibits Mtb-induced Il1b mRNA and boosts Il10 mRNA levels
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Medchemexpress LLC Vafidemstat | 1357362-02-7 | 98.0% | 336.39 | 250 MG
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Vafidemstat (ORY-2001) is an oral, brain penetrant, dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor. It is a novel epigenetic agent developed for the treatment of neurodegenerative diseases. It modulates LSD1, which participates in transcription regulation complexes, to adjust transcriptional imbalances in neurodegenerative diseases and to address neuroinflammation and cognitive deficits. Vafidemstat (ORY-2001) can also be used in the treatment of Alzheimer's disease.
- Oral, brain penetrant.
- Dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor.
- Novel epigenetic agent for the treatment of neurodegenerative diseases.
- Modulates LSD1 to tweak transcriptional imbalances in neurodegenerative disease.
- Redresses neuroinflammation and cognitive deficit.
- Can be used in the treatment of Alzheimer's disease.
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Medchemexpress LLC ETHYL DOCOS-13-ENOAT 100G
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5000206825 ETHYL DOCOS-13-ENOAT 100G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000733457 METHYL 8-BROMOOCTANO 250MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000733731 EXATECAN INTERMEDIAT 250MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000734345 ALLYLPALLADIUMII C 250MG
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Medchemexpress LLC Pyrimidine | 289-95-2 | MFCD00006059 | 100.0% | 80.09 | C4H4N2 | 25g
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Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite Pyrimidine derivatives can be used in pancreatic cancer triple-negative breast cancer colon carcinoma and neuron research[1][2][3]
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000734348 DICHLOROBISTRICYCLO 250MG
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