Pyrimidines And Derivatives
Medchemexpress LLC 9-Aminoacridine | 90-45-9 | 99.4% | 250 MG
9-Aminoacridine is a fluorescent probe functioning as a pH indicator for quantitative determination of transmembrane pH gradients. It also acts as an antimicrobial by interacting with bacterial DNA and disrupting the proton motive force in K. pneumoniae. Furthermore, it is an HIV-1 inhibitor, suppressing HIV LTR transcription and virus replication in infected cell lines, and can serve as a Rifampin adjuvant for multidrug-resistant K. pneumoniae infections.
- Acts as a fluorescent pH indicator.
- Antimicrobial effect against K. pneumoniae.
- Inhibits HIV-1 LTR transcription and virus replication.
- Can be used as a Rifampin adjuvant.
- Shows moderate cytotoxicity to human cell lines.
- Decreases abscess area in skin subcutaneous abscess mice model.
eMolecules METHYL 6-CHLORO-3-METHOXYPICOLINATE | 175965-90-9 | MFCD18257727 | 1g
AstaTech | METHYL 6-CHLORO-3-METHOXYPICOLINATE | 1g | 448263252 | W18514 | 95.000 | 175965-90-9 | MFCD18257727 | 201.610 | C8H8ClNO3
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Cayman Chemical ThIobarbIturIc AcId asy Rea 1g
A multi-kinase inhibitor inhibits FLT3 CSF1R c-Kit FGFR1 FGFR3 VEGFR1 -2 and -3 PDFGRa and PDGFRB (IC50s 1 36 2 8 9 10 13 8 27 and 210 nM respectively) inhibits the proliferation of human multiple myeloma cell lines expressing mutant but not wild-type FGFR3 (IC50s 90-550 and >2500 nM respectively) decreases FGF-induced ERK1/2 phosphorylation and induces apoptosis in patient-derived multiple myeloma cells at 500 nM inhibits bFGF-induced angiogenesis in a Matrigel™ plUG assay in mice at 3-300 mg/kg for 8 days reduces tumor growth in KM12L4A DU145 and MV4-11 mouse xenograft models (ED50s 17 23 and 3 mg/kg per day respectively)