Pyrroles
Selleck Chemical LLC Sacubitril hemicalcium salt S4426-100mg
Sacubitril (AHU-377) hemicalcium salt a component of the heart failure medicine LCZ696 is a potent inhibitor of neprilysin (neutral endopeptidase NEP)
Apexbio Technology LLC Sunitinib malate(Synonyms: Sutent, SU11248, Sunitinib L-malate, Sunitinib malate salt, SU-11248 malate, Sutent malate), 1g, CAS: 341031-54-7.
Sunitinib malate (CAS 341031-54-7) is a small molecule orally bioavailable multitargeted receptor tyrosine kinase inhibitor It inhibits various receptor tyrosine kinases including platelet-derived growth factor receptor (PDGFR) vascular endothelial growth factor receptors (VEGFR-1 2 and 3) c-KIT FLT3 kinase colony-stimulating factor-1 receptor (CSF-1R) and RET kinase In neuroblastoma cell lines (e g SK-N-BE(2) SH-SY5Y LAN-5) treatment with sunitinib malate significantly suppresses proliferation in a dose-dependent manner (IC50 10-20 ng/ml) Preclinical studies show tumor growth inhibition and reduced metastasis in neuroblastoma mouse models highlighting its potential for research in oncology therapeutics
Medchemexpress LLC PHA-767491 hydrochloride | 942425-68-5 | MFCD11519962 | 99.5% | 249.70 | C12H12ClN3O | 5 MG
PHA-767491 hydrochloride is a small-molecule research inhibitor that selectively targets Cdc7 and Cdk9 kinases. It is used in biochemical and cellular studies to probe DNA replication initiation, transcriptional regulation, and cancer cell proliferation. The compound exhibits low-nanomolar biochemical potency and measurable cellular activity, and is supplied as a high-purity solid for laboratory research.
- Potent dual Cdc7/Cdk9 inhibition with low-nanomolar IC50 values.
- Demonstrated cellular antiproliferative activity in multiple cancer cell lines.
- High purity suitable for biochemical and cellular assays.
- Solid, light yellow to yellow appearance for convenient handling.
- Stable under recommended storage conditions for research use.
- Analytical documentation available, including datasheet, COA, and SDS.
Sigma Aldrich Fine Chemicals Biosciences L-Malate Dehydrogenase L-M
L-malateNAD oxidoreductaseThe L-malate dehydrogenase enzyme is a nuclear gene product that is synthesized with a 24-residue amino-terminal signal peptide. This peptide is proteolytically cleaved during the translocation of the enzyme to the mitochondrial matrix.
Selleck Chemical LLC Atorvastatin
Atorvastatin is a lipid lowering agent It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway Atorvastatin activates autophagy
Apexbio Technology LLC AHU-377 hemicalcium salt 1369773-39-6 50mg
AHU-377 hemicalcium salt (CAS 1369773-39-6) is a hemicalcium salt form of AHU-377 a potent inhibitor of neprilysin (neutral endopeptidase) with an IC50 of 5 nM As a prodrug AHU-377 is enzymatically converted to its active metabolite LBQ657 following ester cleavage AHU-377 is a key component of LCZ696 co-formulated with valsartan at a 1 1 molar ratio functioning as an angiotensin receptor neprilysin inhibitor (ARNI) In vivo studies demonstrate that oral administration of AHU-377 induces dose-dependent blood pressure reduction in DAHI-SS rats though it has less pronounced effects in DOCA-salt hypertensive models AHU-377 is widely studied in cardiovascular research particularly in the context of heart failure and hypertension
Medchemexpress LLC HY-19396 5mg Medchemexpress, Ingliforib CAS:186392-65-4 Purity:>98%
Medchemexpress, HY-19396 5mg Ingliforib CAS:186392-65-4 Ingliforib is a glycogen phosphorylase inhibitor, with IC 50 s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC AHU-377 hemicalcium salt 1369773-39-6 5mg
AHU-377 hemicalcium salt (CAS 1369773-39-6) is a hemicalcium salt form of AHU-377 a potent inhibitor of neprilysin (neutral endopeptidase) with an IC50 of 5 nM As a prodrug AHU-377 is enzymatically converted to its active metabolite LBQ657 following ester cleavage AHU-377 is a key component of LCZ696 co-formulated with valsartan at a 1 1 molar ratio functioning as an angiotensin receptor neprilysin inhibitor (ARNI) In vivo studies demonstrate that oral administration of AHU-377 induces dose-dependent blood pressure reduction in DAHI-SS rats though it has less pronounced effects in DOCA-salt hypertensive models AHU-377 is widely studied in cardiovascular research particularly in the context of heart failure and hypertension
Apexbio Technology LLC Pizotifen Malate 5189-11-7 100mg
Pizotifen malate (CAS 5189-11-7) is a benzocycloheptane derivative that functions as a potent antagonist of serotonin (5-HT) receptors exhibiting high selectivity for this target class By inhibiting serotonergic neurotransmission Pizotifen malate is utilized in biomedical research to investigate the physiological and pharmacological roles of 5-HT pathways Its receptor blocking properties enable studies focused on serotonergic modulation migraine mechanisms and disorders associated with altered serotonin signaling
Medchemexpress LLC Atorvastatin | 134523-00-5 | MFCD00899261 | 200 MG
Atorvastatin is an orally active HMG-CoA reductase inhibitor that effectively decreases blood lipids. It inhibits human SV-SMC proliferation and invasion.
- Effectively decreases blood lipids
- Functions as an HMG-CoA reductase inhibitor
- Inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively
=O)C(O)=O.CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C | 50mg | 335409656](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000128617.jpg-250.jpg)
eMolecules 341031-54-7 | Sunitinib Malate | Target Molecule | MFCD08282795 | 532.569 | C26H33FN4O7 | 0.000 | O[C@@H](CC(O)=O)C(O)=O.CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C | 50mg | 335409656
Sunitinib Malate | Target Molecule | 341031-54-7 | MFCD08282795 | 532.569 | C26H33FN4O7 | 0.000 | O[C@@H](CC(O)=O)C(O)=O.CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C | 50mg | 335409656
Apexbio Technology LLC Sunitinib 557795-19-4 100mg
Sunitinib (CAS 557795-19-4) is an orally bioavailable small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) including VEGFR1-3 PDGFR / c-kit and RET Research has shown sunitinib inhibits proliferation in nasopharyngeal carcinoma (NPC) cell lines HK1 CNE-1 CNE-2 HONE-1 and C666-1 with IC50 values ranging from approximately 2 06 to 7 57 M Additionally it induces apoptosis and G0/G1 cell cycle arrest in NPC cell lines and significantly decreases microvessel density in CNE-2 xenograft tumor models in vivo Thus sunitinib is useful for investigating pathways involved in tumor angiogenesis and proliferation
Med Vet International Atorvastatin Tablets (Lipitor), 40mg, 90ct
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Atorvastatin Tablets (lipitor), 40mg, 90ct
Medchemexpress LLC Pitavastatin lactone | 141750-63-2 | MFCD09841193 | 99.3% | 403.45 g/mol | C25H22FNO3 | 5MG
Pitavastatin lactone is the lactone metabolite of the HMG-CoA reductase inhibitor pitavastatin, provided as a high-purity research standard for metabolic, pharmacokinetic, and analytical studies. The material is isolated and characterized for laboratory use and supplied as a white to off-white powder with confirmed molecular data.