Pyrroles
Medchemexpress LLC HY-10484 200mg , MLN4924 (hydrochloride) Pevonedistat hydrochloride CAS:1160295-21-5 Purity:98%
Medchemexpress, HY-10484 200mg MLN4924 (hydrochloride) Pevonedistat hydrochloride CAS:1160295-21-5 Formula:C21H26ClN5O4S IC50: 4.7 nM (NAE) Purity:98% MLN4924 (hydrochloride) is a potent and selective NEDD8-activating enzyme ( NAE ) inhibitor, with IC 50 of 4.7 nM. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-107709 100mg Medchemexpress, MK-4074 CAS:1039758-22-9 Purity:98%
Medchemexpress,HY-107709 100mg MK-4074 CAS:1039758-22-9 Formula:C33H31N3O6 MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM. Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-111378 5mg Medchemexpress, Casein Kinase II Inhibitor IV CAS:863598-09-8 Purity:>98%
Medchemexpress, HY-111378 5mg Casein Kinase II Inhibitor IV CAS:863598-09-8 Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 1-Furfurylpyrrole | 1438-94-4 | 99.07% | 1 ML
1-Furfurylpyrrole is a chemical compound identified as a potential contributor to the flavor and aroma of popcorn.
- Enhances flavor and aroma profile, specifically noted for its contribution to popcorn.
- High purity of 99.07%.
- Soluble in DMSO at 100 mg/mL for in vitro studies.
- Intended for research use only.
eMolecules 1435934-25-0 | Medchem Express | A 419259 (trihydrochloride) | 5mg | 446266566 | HY-15764A | MFCD19690922 | 592.01 | C29H37Cl3N6O
Medchem Express | SAR405 R enantiomer | 2mg | 446261348 | HY-12481A | 1946010-79-2 | MFCD29037449 | 443.860 | C19H21ClF3N5O2
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Medchemexpress LLC Zipalertinib | 1661854-97-2 | 99.6% | 396.44 | 10 MG
Zipalertinib (TAS6417; CLN-081) is a highly effective, orally active, and pan-mutation-selective EGFR tyrosine kinase inhibitor. It features a unique scaffold that fits into the ATP-binding site of the EGFR hinge region, with IC50 values ranging from 1.1-8.0 nM. It inhibits EGFR phosphorylation and downstream molecules in NSCLC cell lines and causes persistent tumor regression in EGFR exon 20 insertion-driven tumor models.
- Highly effective, orally active, and pan-mutation-selective EGFR tyrosine kinase inhibitor
- Inhibits EGFR phosphorylation and downstream molecules
- Causes caspase activation
- Robust against common EGFR mutations and potent against cells with EGFR-T790M
- Inhibits mutant EGFR in tumors but not wild-type EGFR in skin
- Promotes cell growth inhibition and apoptosis
- Prolongs survival in animal models of lung cancer
eMolecules 172732-68-2 | Medchem Express | Varespladib | 5mg | 446262827 | HY-13402 | MFCD00944812 | 380.4 | C21H20N2O5
Medchem Express | Cbl-b-IN-2 | 5mg | 788478274 | HY-141431 | 2503325-21-9 | 575.584 | C29H30F5N5O2
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Medchemexpress LLC JNJ-63576253 | 25MG
JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR) with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC)[1]
eMolecules 1049741-03-8 | Medchem Express | SPD304 (dihydrochloride) | 5mg | 761953613 | HY-111255A | MFCD09265259 | 620.54 | C32H34Cl2F3N3O2
Medchem Express | Ascr5 | 5mg | 600899991 | HY-N6978 | 1086696-26-5 | 220.221 | C9H16O6
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Medchemexpress LLC HY-15424 2mg Medchemexpress, 5-Iodotubercidin CAS:24386-93-4 Purity:>98%
Medchemexpress, HY-15424 2mg 5-Iodotubercidin CAS:24386-93-4 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin[2][3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Jnj-18038683 | 851376-05-1 | 99.8% | 529.97 g/mol | C26H28ClN3O7 | 10 MG
This small-molecule research compound is a selective antagonist of the 5-hydroxytryptamine type 7 (5-HT7) receptor used in pharmacology and neuroscience studies. It shows high affinity in binding assays (pKi ≈ 8.19-8.20 for rat and human 5-HT7 in HEK293 cells), produces concentration-dependent inhibition of 5-HT-stimulated adenylyl cyclase, and alters REM sleep in rodent models. Supplied as a solid or as a DMSO solution for in vitro and in vivo research.
- Selective 5-HT7 receptor antagonist with high binding affinity.
- Demonstrated functional antagonism in adenylyl cyclase assays.
- Modulates REM sleep parameters in rodent studies.
- High purity suitable for research applications.
- Available as solid and ready-to-use DMSO solution.
- Store sealed and protect from moisture; follow supplier storage guidelines.
Selleck Chemical LLC Ribociclib
Ribociclib is an orally available and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM Phase 3
Medchemexpress LLC JMS-17-2 | 1380392-05-1 | MFCD30489012 | 99.2% | 419.95 | C25H26ClN3O | 50MG
JMS-17-2 is a small-molecule research compound that functions as a potent and selective antagonist of the CX3CR1 receptor (IC50 = 0.32 nM). It has been used in preclinical studies to impair metastatic seeding and colonization of breast cancer cells. The material is supplied as a high-purity solid with recommended cold storage for prepared solutions to preserve stability.
- Chemical formula: C25H26ClN3O.
- Molecular weight: 419.95 g·mol-1.
- High purity suitable for research use.
- Appearance: white to off-white solid.
- Storage: store solid at 4°C protected from light; store solutions at -20°C to -80°C for longer-term stability.
- Applications: in vitro and in vivo studies of CX3CR1-mediated processes and metastasis models.
- Available in multiple pack formats including small mg quantities and ready-to-use DMSO solutions.
Medchemexpress LLC EX229, a benzimidazole derivative | 1219739-36-2 | MFCD31696597 | 99.4% | 431.87 | C24H18ClN3O3 | 5 MG
EX229 is a benzimidazole-derived small-molecule allosteric activator of AMP-activated protein kinase (AMPK) used for biochemical and cellular research. It binds AMPK complexes with submicromolar affinity and shows potent cellular activity, suitable for pathway and metabolic studies.
- Potent allosteric activator of AMPK (Kd ≈ 0.06 μM for primary complexes).
- Demonstrated cellular activity (EC50 ≈ 3 nM in Sf21 cell assay).
- High purity (≈99.4%).
- Soluble in DMSO (~13 mg/mL) with recommended in vivo formulation protocols.
- Stable as powder and in solvent when stored under recommended conditions.
- Available in small-mass packs and DMSO solutions for screening workflows.