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Filtered Search Results
Medchemexpress LLC S -3-N-Cbz-Amino-su 1g
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(S)-3-N-Cbz-Amino-succinimide (Compound 1d) is an antiepileptic agent that can inhibit pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced tonic convulsions in mice[1]
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Medchemexpress LLC 1H-Pyrrole-2,5-dione, 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)- | 1417162-36-7 | 99.9% | 433.28 | 5 MG
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RI-2 is a reversible RAD51 inhibitor that specifically inhibits homologous recombination repair in human cells. It has an IC50 of 44.17 μM for RAD51. RI-2 (150 μM) can significantly sensitize cells.
- Reversible RAD51 inhibitor
- Specifically inhibits homologous recombination repair in human cells
- Induces significant sensitization of cells at 150 μM
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Medchemexpress LLC PROTAC ERRα Degrader-3 | 2306388-65-6 | 98.8% | 956.99 | 50 MG
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PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on a von Hippel-Lindau ligand. It can specifically degrade ERRα protein by more than 80% at a concentration of 30 nM and is inactive against ERRβ and ERRγ proteins. It induces ERRα degradation dose-dependently with an efficacious dose as low as 3.0 nM at 4.0 h, also decreasing levels of downstream target genes like ATP5B, MCAD, and PDK4.
- Potent and selective ERRα degrader
- Based on von Hippel-Lindau ligand
- Specifically degrades ERRα protein by >80% at 30 nM
- Inactive against ERRβ and ERRγ proteins
- Induces ERRα degradation dose-dependently from 0.3 nM to 10 μM within 4 hours
- Decreases protein levels of ERRα downstream target genes (ATP5B, MCAD, PDK4)
- Exhibits an IC50 value of 12.67 nM for blocking ERRα with PGC-1α peptide interaction
- Induces approximately 96% protein degradation at 100 nM after 4.0 h treatment
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Medchemexpress LLC Protac CRBN degrader-1 | 2358775-70-7 | MFCD32197292 | 98.8% | 1061.25 g/mol | C53H72N8O13S | 5 MG
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PROTAC CRBN Degrader-1 is a research-grade proteolysis-targeting chimera that induces selective degradation of cereblon (CRBN) by promoting heterodimerization with VHL, enabling studies of targeted protein degradation and ubiquitin-proteasome-mediated pathways. Supplied as a purified small-molecule for in vitro and cellular research; not for human or diagnostic use.
- Selective CRBN degradation via VHL-CRBN heterodimerization.
- High purity suitable for biochemical and cellular assays.
- Available in small-milligram research quantities.
- Molecular formula C53H72N8O13S and molecular weight 1061.25 g/mol.
- Accompanied by product documentation including SDS and COA.
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Sigma Aldrich Fine Chemicals Biosciences N-(5-Fluoresceinyl)Maleimide | 75350-46-8 | MFCD00077345 | 25mg
N-(5-Fluoresceinyl)Maleimide | Purity: 90% | Mol Wt: 427.36 | 75350-46-8 | MFCD00077345 | 25mg
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Medchemexpress LLC Mal-C6-α-amanitin | 1578249-76-9 | 98.5% | 1211.34 | C55H78N12O17S | 2 MG
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Mal-C6-α-amanitin is an antibody-drug conjugate (ADC) payload consisting of α-amanitin covalently linked via a maleimide C6 (Mal-C6) linker. It is supplied as a solid for research use and acts as an RNA polymerase II inhibitor to provide targeted cytotoxicity.
- Drug-linker conjugate for ADC research and payload development.
- High purity: 98.5%.
- Molecular weight 1211.34 Da.
- Molecular formula C55H78N12O17S.
- White to light yellow solid appearance.
- Store at -20°C; in solvent, store at -80°C up to 6 months (protect from light).
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Ambeed 1 2Hydroxyethyl 1Hpyrrole2 5di
1-(2-Hydroxyethyl)-1H-pyrrole-2,5-dione, 1585-90-6, 97%
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Medchemexpress LLC (Rac)-Rhododendrol | 69617-84-1 | 99.8% | 166.22 | 50 MG
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(Rac)-Rhododendrol is an aromatic compound with pro-oxidant activity, potentially useful in suppressing liver diseases. It can be toxic to melanocytes, leading to cell death. Its metabolite, RD-quinone, is cytotoxic, causing enzyme inactivation and endoplasmic reticulum stress by binding to thiol proteins. Additionally, (Rac)-Rhododendrol-derived melanin exhibits potent pro-oxidant activity and may cause oxidative stress.
- Aromatic compound with pro-oxidant activity
- May be useful in suppressing liver diseases
- Can be toxic to melanocytes
- Metabolite RD-quinone is cytotoxic
- Exhibits in vitro cell growth inhibitory activity against K562 cell line
- Soluble in DMSO at 200 mg/mL
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eMolecules 1-(3-Aminophenyl)-pyrrolidin-2,5-dione | 31036-67-6 | MFCD11052202 | 250mg
Oakwood Chemical | 1-(3-Aminophenyl)-pyrrolidin-2,5-dione | 250mg | 537689563 | 038522 | | 31036-67-6 | MFCD11052202 | 190.202 | C10H10N2O2
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Medchemexpress LLC Neuraminidase-IN-1 | 2379438-80-7 | 98.9% | 317.25 | 50 MG
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Neuraminidase-IN-1 is a neuraminidase inhibitor with an IC50 of 0.21 μM. It exhibits excellent activity against the H1N1 influenza virus.
- Neuraminidase inhibitor
- Excellent activity against H1N1 influenza virus
- Good inhibitory effect on A/WSN/33H1N1 virus strains
- Low toxicity and good druggability
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Medchemexpress LLC Azido-PEG6-MS | 352439-38-4 | 95.32% | 385.43 | 100 MG
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Azido-PEG6-MS is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker for PROTAC synthesis.
- Click chemistry reagent.
- Contains an azide group.
- Enables copper-catalyzed azide-alkyne cycloaddition reactions.
- Enables strain-promoted alkyne-azide cycloaddition reactions.
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Medchemexpress LLC N-(hydroxymethyl)phthalimide | 118-29-6 | MFCD00005899 | 98.2% | 177.16 g/mol | C9H7NO3 | 500g
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N-(Hydroxymethyl)phthalimide (Phthalimidomethanol) is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1]
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Medchemexpress LLC 2,5-pyrrolidinedione, 1-bromo- | 128-08-5 | MFCD00005510 | 99.7% | 177.98 | C4H4BrNO2 | 500g
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1-Bromo-2 5-pyrrolidinedione is a collagen protein ligand in docking experiments 1-Bromo-2 5-pyrrolidinedione can be used to study wound healing-related diseases[1]
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Medchemexpress LLC Taltirelin acetate (TA-0910 acetate) | 1549593-23-8 | 99.4% | 50 MG
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Taltirelin acetate (TA-0910 acetate) is an acetate form of Taltirelin (TA-0910), an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist. This compound can cross the blood-brain barrier and stimulates an increase in cytosolic Ca2+ concentration.
- Orally effective analogue of thyrotropin releasing hormone (TRH)
- TRH receptor (TRH-R) superagonist
- Can cross the blood-brain barrier
- Stimulates an increase in cytosolic Ca2+ concentration (Ca2+ release)
- Increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons
- Demonstrates neuroprotective effects in cellular and animal models of Parkinson's disease
- Alleviates fatigue-like behavior in mouse models of cancer-related fatigue
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Medchemexpress LLC (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH | 2086301-47-3 | 99.3% | 754.98 g/mol | C39H58N6O7S | 5 MG
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(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is a Boc-protected VHL ligand-linker conjugate used as a building block in proteolysis-targeting chimera (PROTAC) design, providing a VHL-binding moiety and a trans-3-aminocyclobutanol linker for conjugation.
- Molecular weight 754.98 g/mol.
- CAS number 2086301-47-3.
- High purity ≈99.3% (LCMS).
- Appearance white to off-white solid.
- Storage -20°C, sealed; in solvent: -80°C (6 months), -20°C (1 month).
- Solubility DMSO 100 mg/mL; in vivo formulations soluble ≥2.5-5.5 mg/mL.
- Available pack sizes 1 mg, 5 mg, 10 mg.
- Application VHL ligand for PROTAC E3 ligase recruitment.
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