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Filtered Search Results
Cayman Chemical Bisindolylmaleimide I 10MG
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A highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM); competitive inhibitor for the ATP binding site of PKC; highly selective for PKCα, β1, β2, γ, δ, and ε isozymes; inhibits GSK3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM); competitively antagonizes the 5-HT3 receptor with a Ki value of 61 nM
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eMolecules 1S 4S-2-BOC-2 5-DIAZABICY 5G
5000165108 1S 4S-2-BOC-2 5-DIAZABICY 5G
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Medchemexpress LLC Protac EZH2 Degrader-1 | 2641601-67-2 | 99.4% | 942.15 | 50 MG
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PROTAC EZH2 Degrader-1 (Compound 150d) is a potent PROTAC EZH2 Degrader that inhibits EZH2 methyltransferase activity with an IC50 of 2.7 nM. EZH2 is critical in many tumorigenesis and development processes.
- Potent PROTAC EZH2 Degrader with an IC50 of 2.7 nM for EZH2 methyltransferase activity.
- Exhibits anti-proliferative activity against various cell lines such as EOL1 (IC50: 3.7 μM), MV4-11 (IC50: 5.5 μM), Pfeiffer (IC50: 0.21 μM), RS4-11 (IC50: 5 μM), and WSUDLCL2 (IC50: 3.69 μM).
- Inhibits cell viability in H128-LM (IC50: 1.83 nM), H128-BPM (IC50: 1.9 nM), H128 wildtype (IC50: 3.07 nM), and H128-Mut (IC50: 2.64 nM) cells.
- Enhances the sensitivity of H128-LM cells to Carboplatin, VP16, and VM26.
- Demonstrates antitumor activity against H128-LM in xenograft mouse models when combined with Carboplatin, VP16, or VM26, prolonging survival.
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Medchemexpress LLC 15-Azido-pentadecanoic acid | 118162-46-2 | C15H29N3O2 | 10 MM 1 ML
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15-Azido-pentadecanoic acid is a click chemistry reagent containing an azide group. It is used to identify and characterize post-translationally palmitylated proteins through a simple and robust two-step labeling and detection technique. This reagent can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- Contains an azide group for click chemistry applications
- Identifies and characterizes post-translationally palmitylated proteins
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
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eMolecules Medchem Express / Grazoprevir hydrate / 5mg / 446265392 / HY-15298B / / 1350462-55-3 / MFCD25976702 / 784.930 / C38H52N6O10S
Medchem Express / Grazoprevir hydrate / 5mg / 446265392 / HY-15298B / / 1350462-55-3 / MFCD25976702 / 784.930 / C38H52N6O10S
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![eMolecules Pharmablock / (2R3S)-1-tert-butoxycarbonyl-2-methyl-azetidine-3-carboxylic acid / 25mg / 722715000 / PBZL777 / 0.000 / 2231663-77-5 / [null] / 215.249 / C10H17NO4](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502452719.PNG-250.jpg)
eMolecules Pharmablock / (2R3S)-1-tert-butoxycarbonyl-2-methyl-azetidine-3-carboxylic acid / 25mg / 722715000 / PBZL777 / 0.000 / 2231663-77-5 / [null] / 215.249 / C10H17NO4
Pharmablock / (2R3S)-1-tert-butoxycarbonyl-2-methyl-azetidine-3-carboxylic acid / 25mg / 722715000 / PBZL777 / 0.000 / 2231663-77-5 / [null] / 215.249 / C10H17NO4
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Medchemexpress LLC 3-methyl-4-nitrophenol | 2581-34-2 | MFCD00007333 | 99.7% | 153.14 g/mol | C7H7NO3 | 100 G
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3-methyl-4-nitrophenol is an analytical-grade reagent supplied for laboratory research and environmental contaminant reference work. It is provided as a solid with confirmed high purity and characterized identifiers for analytical use.
- high purity suitable for analytical applications.
- single CAS registry number for unambiguous identification.
- well-characterized molecular formula and weight for calculations.
- available in multiple pack sizes, including a 100 g unit of measure.
- stability information provided for solvent storage at low temperatures.
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Medchemexpress LLC Bisindolylmaleimide V | 113963-68-1 | 97.75% | 341.36 | 500 MG
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Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies, with an IC50 value exceeding 100 μM. It also blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo, with an IC50 of 8 μM. This product is intended for research use only and is not sold to patients.
- Cell-permeable negative control for protein kinase C inhibition studies.
- Blocks activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo.
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Medchemexpress LLC Racemic 3-hydroxyphenylglycine | 31932-87-3 | 99.6% | 167.16 g/mol | C8H9NO3 | 5 MG
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(Rac)-3-Hydroxyphenylglycine is a racemic mixture of the S- and R-enantiomers of 3-hydroxyphenylglycine. The S-enantiomer is reported to act as a potent, selective agonist of the metabotropic glutamate receptor 1 (mGluR1). The material is supplied as an off-white to gray solid for research use and is commonly used in neuroscience and receptor pharmacology studies.
- Racemic mixture of S- and R-enantiomers.
- Potent, selective mGluR1 agonist (activity attributed to the S-enantiomer).
- High purity, suitable for research applications.
- Available in small, milligram-scale quantities for screening.
- Solid form; follow low-temperature storage to maintain stability.
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Molecular Dimensions MOLECULAR DIMENSIONS INC
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NC3975907 WIZARD SCREEN 1 2 COMBO
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Medchemexpress LLC (3R)-3-Pyrrolidinemethanol | 110013-18-8 | >99.96% | C5H11NO | 500 MG
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(3R)-3-Pyrrolidinemethanol is a molecular building block that serves as a linker for various chemical syntheses. This compound is typically found as a colorless to off-white liquid.
- Molecular weight: 101.15
- Chemical formula: C5H11NO
- CAS number: 110013-18-8
- Shipment conditions: Room temperature in continental US
- Storage conditions: Store at room temperature, protect from light. In solvent: -80°C for 1 year, -20°C for 6 months.
- Solubility (In Vitro): DMSO: 175 mg/mL (1730.10 mM)
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Medchemexpress LLC (Rac)-LY341495 | 201943-63-7 | >96.5% | C20H19NO5 | 100 MG
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(Rac)-LY341495 is an isomer of LY341495 (HY-70059) and can be used as a control compound in experiments. LY341495 is a metabotropic glutamate receptor (mGluR) antagonist.
- Suitable for use as a control compound in experiments
- Functions as a metabotropic glutamate receptor (mGluR) antagonist
- Exhibits IC50s for mGlu2 (21 nM), mGlu3 (14 nM), mGlu1a (7.8 μM), mGlu5a (8.2 μM), mGlu8 (170 nM), mGlu7 (990 nM), and mGlu4 (22 μM) receptors.
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Medchemexpress LLC Poly(2-hydroxyethyl methacrylate) | 25249-16-5 | 300000 (Average) | 10 G
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Poly(2-hydroxyethyl methacrylate) is a biocompatible, optically transparent, hydrophilic, and non-degradable polymer known for excellent cytocompatibility and minimal immunological response. It is suitable for various biomedical applications, including bone tissue regeneration, wound dressings, and drug delivery.
- Forms hydrogels by absorbing water or biological fluids through hydrophilic pendant groups.
- Utilized in applications such as soft contact lenses, tissue regeneration, cancer research, ocular drug delivery, artificial skin, and artificial cornea.
- Can be loaded with Quercetin (QT) to synthesize QT-pHEMA-GelCryoMem, demonstrating antimicrobial activity against *S. aureus*.
- Applicable in wound dressings, scaffolds, or drug delivery.
- Can be used in the synthesis of spongy materials with antimicrobial properties, suitable for wound and burn dressing applications.
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Medchemexpress LLC 4- 4-Boc-piperazinem 1g | 1G
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4- 4-Boc-piperazinem 1g | 1G
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TARGETMOL CHEMICALS INC Z-Semaxinib 5MG
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Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. (Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50 1.23 uM), 20-fold more selective for VEGFR over PDGFRbeta, no inhibition for FGFR, InsR, and EGFR. (Z)-Semaxinib is a quinolone derivative with potential antineoplastic activity. Purity 99.94%
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