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Filtered Search Results
Apexbio Technology LLC SU 9516 377090-84-1 5mg
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SU 9516 (CAS 377090-84-1) is a potent and selective inhibitor of cyclin-dependent kinase 2 (CDK2) with an IC50 of 22 nM It exhibits markedly reduced activity against CDK1 CDK4 PKC p38 and PDGFR SU 9516 disrupts cell cycle progression by inhibiting CDK2-mediated phosphorylation of the retinoblastoma protein (pRb) and induces cell cycle arrest and apoptosis in various cancer cell lines including colon carcinoma and leukemia It has been shown to reduce levels of Cyclin D1 and CDK2 promote mitochondrial translocation of Bax cytochrome c release and activate caspase cascades SU 9516 serves as a valuable chemical probe for investigating CDK2 function and cell cycle regulation in cancer research
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000380107 PROTAC PD-1 PD-L1 DE 50MG
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Medchemexpress LLC HY-42424A 100mg Medchemexpress, (S,R,S)-AHPC-Me (dihydrochloride) CAS: Purity:>98%
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Medchemexpress, HY-42424A 100mg (S,R,S)-AHPC-Me (dihydrochloride) CAS: (S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein [1] . (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC 50 <1 nM [2] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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MEDCHEMEXPRESS LLC COTININE 100MG
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501874410 COTININE 100MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000586167 RAC-EMTRICITABINE 1MG
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eMolecules 2-(2-Naphthyl)pyrrolidine | 100710-37-0 | MFCD02663521 | 1g
Combi-Blocks | 2-(2-Naphthyl)pyrrolidine | 1g | 457915144 | QA-0556 | 95.000 | 100710-37-0 | MFCD02663521 | 197.281 | C14H15N
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Medchemexpress LLC Z-Leu-Leu-Nle-CHO | 133407-83-7 | 97.6% | 5 MG
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Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a peptide aldehyde research reagent used as a γ-secretase inhibitor in biochemical and cell biology studies. It inhibits γ-secretase activity and has been reported to induce caspase- and ROS-dependent apoptosis by interfering with Akt-mediated survival pathways. The compound is supplied in small milligram quantities for laboratory research and assay preparation.
- Peptide aldehyde inhibitor of γ-secretase
- Used to study apoptosis and Akt signaling pathways
- High purity suitable for research applications
- Multiple small milligram package sizes available
- Soluble in common organic solvents for assay preparation
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Medchemexpress LLC Rac-PF-06256142 | 1609580-97-3 | 99.6% | 1 ML
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The racemic form of PF-06256142 is a D1 dopamine receptor agonist supplied as a 10 mM solution in DMSO for research use. It is intended for in vitro and in vivo pharmacology studies of D1 receptor signaling.
- Racemic D1 receptor agonist with EC50 107 nM.
- Supplied as a 10 mM solution in DMSO, 1 mL vial.
- High purity suitable for research applications.
- Molecular weight 356.38 g/mol; formula C21H16N4O2.
- Soluble in DMSO (25 mg/mL) and compatible with multiple in vivo vehicles.
- Stable under recommended storage conditions for powder and solution.
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Medchemexpress LLC Maleimide-C10-NHS ester | 87981-04-2 | 98.0% | 378.42 | 100 MG
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Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. These compounds leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system for selective target protein degradation
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Apexbio Technology LLC Z-DQMD-FMK 767287-99-0 25mg
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Z-DQMD-FMK is a small-molecule inhibitor targeting caspase-3 It is designed to selectively and irreversibly inhibit caspase-3 thereby modulating caspase-3-mediated signaling pathways and apoptotic processes Z-DQMD-FMK exerts its biological activity primarily through covalent binding to active thiol residues of caspase-3 via its fluoromethyl ketone group resulting in irreversible inhibition Based on these pharmacological properties Z-DQMD-FMK holds research potential in investigating apoptotic mechanisms caspase-3-dependent signaling and proteolytic processing events including protein kinase C isoform cleavage under zinc deficiency oxidative stress and ischemic injury
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eMolecules TERT-BUTYL 3R-3-AMINOPYRR 1G
5000191792 TERT-BUTYL 3R-3-AMINOPYRR 1G
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eMolecules Medchem Express / Fedovapagon / 5mg / 475641628 / HY-14887 / / 347887-36-9 / MFCD19443737 / 462.594 / C27H34N4O3
Medchem Express / Fedovapagon / 5mg / 475641628 / HY-14887 / / 347887-36-9 / MFCD19443737 / 462.594 / C27H34N4O3
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Medchemexpress LLC (all-Z)-6,9,12,15,18-heneicosapentaenoic acid ethyl ester | 131775-86-5 | >=98.0% | 344.53 | C23H36O2 | 50MG
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(all-Z)-6,9,12,15,18-heneicosapentaenoic acid ethyl ester is the ethyl ester derivative of heneicosapentaenoic acid, a 21-carbon omega-3 polyunsaturated fatty acid. Supplied for research use as a reagent and reference standard, it is used in lipid metabolism studies, analytical chemistry, and method development. Molecular formula C23H36O2; molecular weight 344.53; CAS 131775-86-5.
- Used as a reference standard for lipid analysis and method development.
- Suitable for studies of fatty acid metabolism and biochemical assays.
- Stable ethyl ester form for analytical handling and storage.
- Characterized by molecular formula C23H36O2 and molecular weight 344.53.
- Available in multiple pack sizes and purity grades depending on supplier.
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Medchemexpress LLC 3-methyl-4-nitrophenol | 2581-34-2 | MFCD00007333 | 99.7% | 153.14 g/mol | C7H7NO3 | 100 G
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3-methyl-4-nitrophenol is an analytical-grade reagent supplied for laboratory research and environmental contaminant reference work. It is provided as a solid with confirmed high purity and characterized identifiers for analytical use.
- high purity suitable for analytical applications.
- single CAS registry number for unambiguous identification.
- well-characterized molecular formula and weight for calculations.
- available in multiple pack sizes, including a 100 g unit of measure.
- stability information provided for solvent storage at low temperatures.
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eMolecules 1-BOC-AMINOCYCLOPROPANECA 5G
5000161167 1-BOC-AMINOCYCLOPROPANECA 5G
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