Pyrrolidines

Organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that form a cyclic secondary amine.

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1,126 – 1,140 of 6,304 results

1,126

Medchemexpress LLC (Z)-Lanoconazole | 101529-65-1 | 98.7% | C14H10ClN3S2 | 25 MG

(Z)-Lanoconazole is the Z configuration of Lanoconazole, a potent and orally active imidazole antifungal agent. It exhibits a broad spectrum of activity against fungi both in vitro and in vivo by interfering with ergosterol biosynthesis, specifically inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. This agent is suitable for the investigation of dermatophytosis and onychomycosis.

Potent and orally active imidazole antifungal agent
Broad spectrum of activity against fungi in vitro and in vivo
Interferes with ergosterol biosynthesis
Inhibits sterol 14-alpha demethylase
Blocks fungal membrane ergosterol biosynthesis
Used for investigation of dermatophytosis and onychomycosis
Suppresses TPA-induced irritant dermatitis in vivo
Inhibits C. neoformans in vivo and reduces its growth in lungs and brains of MAIDS mice

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1,127

STA Pharmaceutical DNA C(Bz) amidite | 25 g | CAS 102212-98-6 | MDL MFCD00036315

DNA C(Bz) amidite is a Amidite reagent (Subcategory: Cytosine Series) sold by WuXi TIDES. Offered in 25 g. Store at -20 °C. SDS available for reference.

Specifications
- CAS: 102212-98-6
- MDL: MFCD00036315
- InChIKey: PGTNFMKLGRFZDX-SALLYJDFSA-N
- Molecular Weight: 833.922761998
- Molecular Formula: C46H52N5O8P
- Purity: ≥99%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1C[C@H](N2C(N=C(C=C2)NC(C3=CC=CC=C3)=O)=O)O[C@@H]1COC(C4=CC=C(C=C4)OC)(C5=CC=C(C=C5)OC)C6=CC=CC=C6)OCCC#N)C(C)C)C

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1,128

Medchemexpress LLC (E/Z)-Teriflunomide | 108605-62-5 | 99.9% | 270.21 | 10 MG

(E/Z)-Teriflunomide is the active metabolite of Leflunomide. Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). It can be used for the research of rheumatoid arthritis (RA).

Active metabolite of Leflunomide
Immunomodulatory agent
Inhibits mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)
Suitable for rheumatoid arthritis (RA) research

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1,129

Medchemexpress LLC J147 | 1146963-51-0 | 99.5% | 350.34 | 100 MG

(E/Z)-J147 is an exceptionally potent, orally active neuroprotective agent that enhances cognitive function. It can easily cross the blood-brain barrier (BBB) and shows potential for the study of Alzheimer's disease (AD). It inhibits monoamine oxidase B (MAO B) and the dopamine transporter.

Neuroprotection and cognitive enhancement
Readily passes the blood-brain barrier (BBB)
Inhibits monoamine oxidase B (MAO B) with an EC50 value of 1.88 μM and the dopamine transporter with an EC50 value of 0.649 μM
Shows potential for the study of Alzheimer's disease (AD)
Promotes HT22 and primary cell survival in a dose-dependent manner, with an EC50 value range of 0.06-0.115 μM
Enhances memory and dendritic spine number in old mice when administered in their diet at 200 ppm for 6 months
Half-life (t1/2) in plasma is 1.5 hours and in the brain is 2.5 hours after a single oral dose of 20 mg/kg

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1,130

Medchemexpress LLC Z-L(D-Val)G-CHN2 | 00-00-0 | 99.4% | 445.51 g·mol⁻¹ | C22H31N5O5 | 5 MG

Z-L(D-Val)G-CHN2 is a tripeptide-derived, cell-permeable, irreversible inhibitor of cysteine proteinases that mimics part of the human protease-binding center. It has reported antiviral activity, including inhibition of herpes simplex virus replication and blockade of SARS-CoV-2 3CL protease activity (reported EC50 = 190 nM). Supplied as a high-purity research reagent for in vitro studies.

Irreversible inhibition of cysteine proteinases.
Tripeptide-derived structure that mimics the protease-binding center.
Demonstrated antiviral activity against HSV and SARS-CoV-2 (3CL protease inhibition).
High purity (reported 99.35%).
Provided in a small laboratory-scale quantity suitable for in vitro work.
Molecular weight 445.51 g·mol⁻¹, characterized by analytical data.

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1,131

TARGETMOL CHEMICALS INC E Z-Zotiraciclib 10MG

Also available in 1 mL, 1 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. (E/Z)-Zotiraciclib ((E/Z)-TG02) effectively inhibits CDK2, JAK2, and FLT3 with IC50s of 13 nM, 73 nM, and 56 nM, respectively. Purity 99.12%

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1,132

eMolecules 934587-44-7 | (R)-2-Amino-3-Cbz-amino-propionic acid methyl ester hydrochloride | J & W PharmLab LLC288.730 | C12H17ClN2O4 | 96.000 | Cl.COC(=O)[C@H](N)CNC(=O)OCc1ccccc1 | 1g | 553407572

(R)-2-Amino-3-Cbz-amino-propionic acid methyl ester hydrochloride | J & W PharmLab LLC | 934587-44-7288.730 | C12H17ClN2O4 | 96.000 | Cl.COC(=O)[C@H](N)CNC(=O)OCc1ccccc1 | 1g | 553407572

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1,133

Medchemexpress LLC (all-Z)-6,9,12,15,18-heneicosapentaenoic acid ethyl ester | 131775-86-5 | 94.0% | 344.5 g/mol | C23H36O2 | 5MG

(all-Z)-6,9,12,15,18-Heneicosapentaenoic acid ethyl ester is the ethyl ester derivative of heneicosapentaenoic acid, an ω-3 polyunsaturated fatty acid. It is used as a research reagent and analytical reference standard in biochemical and lipid metabolism studies. Key identifiers include CAS 131775-86-5, formula C23H36O2, and molecular weight ≈344.5 g/mol.

Ethyl ester form for increased lipophilicity and stability.
Used as a reference standard in lipid metabolism and analytical assays.
Reported purity range 94-98%; verify certificate of analysis.
Typically supplied in small quantities suitable for analytical use (for example, 5 mg).
Characterized by CAS and standard structural identifiers for unambiguous identification.

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1,134

Medchemexpress LLC Cbz-NH-PEG4-C2-acid | 756526-00-8 | MFCD11041139 | ≥95.0% | 399.44 g·mol⁻¹ | C19H29NO8 | 500 MG

Cbz-NH-PEG4-C2-acid is a Cbz-protected, PEG-based linker designed for assembly of PROTAC molecules. It couples a four-unit polyethylene glycol spacer with a C2-terminal carboxylic acid and a Cbz-protected amine to enable modular conjugation between ligands and facilitate synthesis workflows.

Provides a PEG4 spacer for flexible, water-soluble linkage.
Has a Cbz-protected amine for orthogonal protection and selective deprotection.
Features a C2-terminal carboxylic acid for amide or ester coupling.
Optimized for PROTAC synthesis and bioconjugation workflows.
Suitable for use in standard organic coupling reactions.

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1,135

Medchemexpress LLC (Z)-JQ1-TCO | 2087490-43-3 | 99.3% | 609.18 | 100 MG

JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1, an inhibitor of BET. This compound is suitable for click chemistry and can be used as molecular probes in vitro and in vivo. Studies indicate that (Z)-JQ1-TCO does not induce significant degradation of BRD4 in HeLa cells at 10 μM for 18 h.

Derivative of JQ1, an inhibitor of BET
Suitable for click chemistry
Can be used as molecular probes in vitro and in vivo
Does not induce significant degradation of BRD4 in HeLa cells at 10 μM for 18 h
Targets BRD4 and the Epigenetic Reader Domain

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1,136

BLD PHARMATECH CO LIMITED (3S,4S)-4-(Trifluoromethyl)pyrrolidine-3-carboxylic acid, CAS Number: 1909288-71-6, 1g, Purity: 98%

(3S,4S)-4-(Trifluoromethyl)pyrrolidine-3-carboxylic acid, CAS Number: 1909288-71-6, 1g, Purity: 98%

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1,137

Medchemexpress LLC 2-Oxazolidinone, 3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-, (4S)- | 133812-16-5 | 99.5% | 245.27 | 100 MG

(E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic form of Locostatin. Locostatin (UIC-1005) acts as a potent RKIP inhibitor. It functions by binding to the Raf kinase inhibitor RKIP protein, thereby disrupting the interaction between RKIP and Raf-1 kinase, as well as G protein-coupled receptor kinase 2. Locostatin has been shown to inhibit cell proliferation and migration. Additionally, it has been observed to aggravate thioacetamide (HY-Y0698)-induced acute liver failure in mice.

Racemic form of locostatin
Potent RKIP inhibitor
Disrupts interaction of RKIP with raf-1 kinase and G protein-coupled receptor kinase 2
Inhibits cell proliferation and migration

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1,138

Medchemexpress LLC Z-VDVAD-FMK | 210344-92-6 | ≥98.0% | 695.73 | 25 MG

Z-VDVAD-FMK is a special inhibitor of caspase-2, observed to reduce Lovastatin-induced apoptosis. It significantly diminishes Lovastatin-induced DNA loss and inhibits Rho-kinase activity in HMEC-1 cells when stimulated by Thrombin.

Inhibits caspase-2
Reduces Lovastatin-induced apoptosis
Prevents many morphological features of apoptosis in cotreatment with other caspase inhibitors
Greatly inhibits Rho-kinase activity in HMEC-1 cells stimulated by Thrombin
Significantly reduces Lovastatin-induced loss of DNA

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1,139

Medchemexpress LLC E/Z-HA155 10mg | 1229652-22-5 | 463.29 g/mol | C24H19BFNO5S | 10 MG

(E/Z)-HA155 is a potent autotaxin (ATX) type I inhibitor supplied for laboratory research use. It is used to support studies into cancer, fibrotic diseases, inflammation, pain, and angiogenesis. For research use only; not for human or clinical application.

Potent autotaxin type I inhibition for biochemical assays.
Applicable to cancer, fibrosis, inflammation, pain, and angiogenesis research.
High purity (99.26%) suitable for cellular and biochemical experiments.
Supplied as a small-scale powder for dose optimization and pilot studies.
Stored and handled per standard laboratory safety procedures for research reagents.

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1,140

Medchemexpress LLC Z-LLY-FMK | 133410-84-1 | 98.7% | 557.65 g/mol | C30H40FN3O6 | 5 MG

Z-LLY-FMK (Calpain Inhibitor IV) is a cell-permeable, irreversible peptide-based inhibitor of calpain proteases used in research to investigate apoptosis and parasite infection models. It is supplied as a solid powder with high reported purity and characterized chemical properties for laboratory use.

Irreversible inhibitor of calpain proteases, useful for apoptosis studies.
Cell-permeable peptide suitable for in vitro and in vivo research.
High purity (~98.7%) for reliable experimental results.
White to off-white solid with good solubility in common organic solvents.
Stability information provided for powder and solution storage.

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Pyrrolidines

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Medchemexpress LLC (Z)-Lanoconazole | 101529-65-1 | 98.7% | C14H10ClN3S2 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (E/Z)-Teriflunomide | 108605-62-5 | 99.9% | 270.21 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC J147 | 1146963-51-0 | 99.5% | 350.34 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Z-L(D-Val)G-CHN2 | 00-00-0 | 99.4% | 445.51 g·mol⁻¹ | C22H31N5O5 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (all-Z)-6,9,12,15,18-heneicosapentaenoic acid ethyl ester | 131775-86-5 | 94.0% | 344.5 g/mol | C23H36O2 | 5MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cbz-NH-PEG4-C2-acid | 756526-00-8 | MFCD11041139 | ≥95.0% | 399.44 g·mol⁻¹ | C19H29NO8 | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (Z)-JQ1-TCO | 2087490-43-3 | 99.3% | 609.18 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2-Oxazolidinone, 3-(1-oxo-2-buten-1-yl)-4-(phenylmethyl)-, (4S)- | 133812-16-5 | 99.5% | 245.27 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Z-VDVAD-FMK | 210344-92-6 | ≥98.0% | 695.73 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC E/Z-HA155 10mg | 1229652-22-5 | 463.29 g/mol | C24H19BFNO5S | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Z-LLY-FMK | 133410-84-1 | 98.7% | 557.65 g/mol | C30H40FN3O6 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More