Pyrrolidines
Medchemexpress LLC Carbonic Anhydrase 1 10ug
Carbonic Anhydrase 14 Protein catalyzes the reversible hydration of carbon dioxide converting it to bicarbonate ions and protons and vice versa Its vital enzymatic activity contributes to physiological processes regulating acid-base balance respiration and cellular pH homeostasis The protein plays a pivotal role in carbon dioxide transport and metabolism in the body Carbonic Anhydrase 14 Protein Human (HEK293 His) is the recombinant human-derived Carbonic Anhydrase 14 protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC Carbonic Anhydrase 1 100ug
Carbonic Anhydrase 14 Protein catalyzes the reversible hydration of carbon dioxide converting it to bicarbonate ions and protons and vice versa Its vital enzymatic activity contributes to physiological processes regulating acid-base balance respiration and cellular pH homeostasis The protein plays a pivotal role in carbon dioxide transport and metabolism in the body Carbonic Anhydrase 14 Protein Human (HEK293 His) is the recombinant human-derived Carbonic Anhydrase 14 protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC Carbonic Anhydrase 1 50ug
Carbonic Anhydrase 14 Protein catalyzes the reversible hydration of carbon dioxide converting it to bicarbonate ions and protons and vice versa Its vital enzymatic activity contributes to physiological processes regulating acid-base balance respiration and cellular pH homeostasis The protein plays a pivotal role in carbon dioxide transport and metabolism in the body Carbonic Anhydrase 14 Protein Human (HEK293 His) is the recombinant human-derived Carbonic Anhydrase 14 protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC E/Z-HA155 1mg | 1229652-22-5 | 463.29 g·mol-1 | C24H19BFNO5S | 1 MG
(E/Z)-HA155 is a boronic acid-based autotaxin (ATX) type I inhibitor used in preclinical research. It is reported to inhibit ATX with high potency (IC50 ≈ 5.7 nM) and is used to study cancer, fibrotic diseases, inflammation, pain, and angiogenesis.
- Potent autotaxin (ATX) type I inhibitor (IC50 ≈ 5.7 nM).
- High purity: 99.26%.
- Available in multiple lab-scale pack sizes, including 1 mg vials and DMSO solution.
- Molecular formula C24H19BFNO5S; molecular weight 463.29 g·mol-1.
- Supplied as an E/Z isomer mixture suitable for biochemical and cell-based assays.
Apexbio Technology LLC 2'-Azido-dATP 100ul (100 mM)
2p-Azido-dATP is a sugar-modified nucleoside triphosphate analog It incorporates a 2 -azido group substitution at the sugar moiety which allows its enzymatic integration into nucleic acids and leads to oligonucleotide derivatives with modified biochemical and biophysical characteristics 2p-Azido-dATP exerts its biological activity primarily through structural incorporation into nucleic acids during polymerization resulting in increased nuclease stability enhanced target binding affinity and reduced immunogenicity Based on these properties 2p-Azido-dATP holds research potential in nucleic acid therapeutics such as antisense oligonucleotides siRNA development gene-editing and aptamer-based applications
Apexbio Technology LLC 2'-Azido-dATP 10ul (100 mM)
2p-Azido-dATP is a sugar-modified nucleoside triphosphate analog It incorporates a 2 -azido group substitution at the sugar moiety which allows its enzymatic integration into nucleic acids and leads to oligonucleotide derivatives with modified biochemical and biophysical characteristics 2p-Azido-dATP exerts its biological activity primarily through structural incorporation into nucleic acids during polymerization resulting in increased nuclease stability enhanced target binding affinity and reduced immunogenicity Based on these properties 2p-Azido-dATP holds research potential in nucleic acid therapeutics such as antisense oligonucleotides siRNA development gene-editing and aptamer-based applications
Apexbio Technology LLC 2'-Azido-dATP 50ul (100 mM)
2p-Azido-dATP is a sugar-modified nucleoside triphosphate analog It incorporates a 2 -azido group substitution at the sugar moiety which allows its enzymatic integration into nucleic acids and leads to oligonucleotide derivatives with modified biochemical and biophysical characteristics 2p-Azido-dATP exerts its biological activity primarily through structural incorporation into nucleic acids during polymerization resulting in increased nuclease stability enhanced target binding affinity and reduced immunogenicity Based on these properties 2p-Azido-dATP holds research potential in nucleic acid therapeutics such as antisense oligonucleotides siRNA development gene-editing and aptamer-based applications
Medchemexpress LLC Cbz-NH-PEG4-C2-acid | 756526-00-8 | MFCD11041139 | ≥95.0% | 399.44 g·mol⁻¹ | C19H29NO8 | 500 MG
Cbz-NH-PEG4-C2-acid is a Cbz-protected, PEG-based linker designed for assembly of PROTAC molecules. It couples a four-unit polyethylene glycol spacer with a C2-terminal carboxylic acid and a Cbz-protected amine to enable modular conjugation between ligands and facilitate synthesis workflows.
- Provides a PEG4 spacer for flexible, water-soluble linkage.
- Has a Cbz-protected amine for orthogonal protection and selective deprotection.
- Features a C2-terminal carboxylic acid for amide or ester coupling.
- Optimized for PROTAC synthesis and bioconjugation workflows.
- Suitable for use in standard organic coupling reactions.
Medchemexpress LLC Cbz-NH-PEG4-C2-acid | 756526-00-8 | MFCD11041139 | 95.0% | 399.44 g/mol | C19H29NO8 | 250 MG
Cbz-NH-PEG4-C2-acid is a PEG-based linker designed for PROTAC synthesis. It features a Cbz-protected amino group and a terminal carboxylic acid separated by a four-unit ethylene glycol spacer, providing solubility and flexibility for conjugation. The compound is intended for use in medicinal chemistry to connect ligands and enable targeted protein degrader construction.
- Cbz-protected amino group for selective deprotection
- Terminal carboxylic acid enables standard amide-coupling chemistries
- PEG4 spacer imparts flexibility and improves solubility
- Suitable for PROTAC linker construction and linker optimization studies
- Available in common laboratory pack sizes for synthesis workflows
Medchemexpress LLC Cbz-NH-PEG12-C2-acid | 1334177-88-6 | 95.7% | C35H61NO16 | 10MG
Cbz-NH-PEG12-C2-acid is a PEG-based PROTAC linker (C35H61NO16, MW 751.86 g·mol⁻¹) that serves as a hydrophilic spacer between ligand moieties. It bears a Cbz-protected amine and a terminal carboxylic acid, providing orthogonal functional groups for coupling and downstream modifications in medicinal chemistry and PROTAC assembly.
- PEG12 spacer provides hydrophilicity and conformational flexibility.
- Cbz-protected amine enables selective deprotection and subsequent functionalization.
- Terminal carboxylic acid is compatible with amide and ester coupling chemistries.
- Optimized for use as a linker in PROTAC synthesis and related conjugation strategies.
- Supplied with high purity suitable for synthetic applications.
Medchemexpress LLC Cbz-NH-PEG4-C2-acid | 756526-00-8 | MFCD11041139 | >95.0% | 399.44 g·mol⁻¹ | C19H29NO8 | 100 MG
Cbz-NH-PEG4-C2-acid is a Cbz-protected PEG-based linker containing a PEG4 spacer and a two-carbon carboxylic acid terminus, intended for use in PROTAC synthesis and related medicinal chemistry applications. The protected amine allows selective deprotection and downstream coupling to assemble bifunctional molecules.
- Cbz-protected amine for selective deprotection.
- PEG4 spacer provides linker flexibility and improved solubility.
- C2 carboxylic acid terminus enables standard coupling chemistries.
- Suitable for PROTAC and bioconjugation synthesis workflows.
- Available in multiple pack sizes for research-scale use.
- Characterized by molecular formula and molecular weight; consult SDS for purity details.
Medchemexpress LLC Azido-PEG9-acid | 1670249-37-2 | 97.7% | 511.56 g/mol | C21H41N3O11 | 1 G
Azido-PEG9-acid is an azide-terminated 9-unit polyethylene glycol linker with a terminal carboxylic acid. It is used as a non-cleavable PEG linker for conjugation chemistry and click-based bioconjugation applications.
- Non-cleavable 9-unit PEG linker suitable for ADC and PROTAC synthesis.
- Azide functional group enables CuAAC and strain-promoted azide-alkyne cycloaddition (SPAAC).
- Molecular weight 511.56 g/mol; formula C21H41N3O11.
- Purity approximately 97.7%.
- Appearance: colorless to light yellow liquid; storage: -20°C for long-term.
Medchemexpress LLC 1-(2,5-dioxopyrrolidin-1-yl)oxy-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid | 1193111-39-5 | MFCD20227457 | 92.1% | 406.45 | C13H14N2O7S3 | 25 MG
sulfo-SPDB is a cleavable antibody-drug conjugate (ADC) linker featuring a pyridyldisulfide-based disulfide that is reductively cleavable and a sulfonic acid moiety to improve solubility. It is supplied for research use and is designed for preparing linker-drug intermediates and conjugation to antibodies under controlled, reducing conditions.
- Cleavable disulfide linker enabling reductive release of payload.
- Sulfonic acid group improves aqueous solubility.
- High solubility in DMSO (≥125 mg/mL) for formulation flexibility.
- Compatible with standard ADC conjugation workflows.
- Requires cold storage and protection from light for stability.
Medchemexpress LLC Azido-PEG24-acid | 2195075-62-6 | 99.9% | C51H101N3O26 | 10MG
Azido-PEG24-acid is a polyethylene glycol (PEG)-based linker bearing a terminal azide, supplied as a solid for use in bioconjugation and linker synthesis. It facilitates efficient click chemistry conjugations and requires low-temperature, moisture-free storage to preserve stability.
- PEG-based linker with terminal azide for click reactions.
- Enables copper-catalyzed azide-alkyne cycloaddition and strain-promoted cycloaddition.
- High purity (≈99.9%) suitable for synthesis and conjugation.
- Molecular weight ≈1,172.35 g/mol for predictable spacer length.
- Solid, white to light yellow appearance for easy handling.
- Store sealed, away from moisture at low temperatures to maintain stability.
Medchemexpress LLC 4,7,10,13,16,19,22,25,28-nonaoxatriacontanoic acid, 30-azido | 1670249-37-2 | 97.7% | 511.56 | C21H41N3O11 | 25 MG
Azido-PEG9-acid is an azide-terminated polyethylene glycol (PEG) linker containing nine ethylene glycol units. It is used as a non-cleavable linker in antibody-drug conjugate synthesis and as a PEG-based PROTAC linker; the azide group enables CuAAC and SPAAC click reactions for bioconjugation.
- Used as a click chemistry reagent for CuAAC and SPAAC reactions.
- Non-cleavable PEG9 spacer increases solubility and flexibility.
- Contains a terminal carboxylic acid for conjugation to other functional groups.
- High purity suitable for bioconjugation and linker synthesis.
- Stable when stored at -20°C in pure form for extended periods.
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