Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC GDC-0941 957054-30-7 200mg
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GDC-0941 (CAS 957054-30-7) is a selective small-molecule inhibitor of class I phosphoinositide 3-kinase (PI3K) a critical component involved in the PI3K/Akt signaling pathway frequently dysregulated in cancer By competitively binding to the ATP-binding site of PI3K GDC-0941 inhibits generation of the downstream signaling molecule phosphatidylinositol-3 4 5-trisphosphate (PIP3) Exhibiting high selectivity against p110 / (IC50 approx 3 nM) and moderate selectivity for p110 (33 nM) and p110 (75 nM) GDC-0941 has demonstrated antiproliferative activity across diverse tumor cell lines in vitro (e g A2780 PC3 U87MG) and tumor growth inhibition in xenograft cancer models supporting its utility in cancer research
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Apexbio Technology LLC MK-8245 1030612-90-8 200mg
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MK-8245 (CAS 1030612-90-8) is a potent liver-selective small molecule inhibitor of stearoyl-CoA desaturase (SCD) SCD1 catalyzes fatty acid desaturation and represents a target for treating type II diabetes obesity dyslipidemia and other metabolic disorders MK-8245 demonstrates strong inhibitory activity against rat mouse and human SCD1 with an IC50 of approximately 1 nM and displays liver-specific tissue distribution mediated by organic anion transporting polypeptides (OATPs) Animal studies revealed MK-8245 reduces blood glucose levels and hepatic triglycerides dose-dependently supporting its application in metabolic disease research
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Medchemexpress LLC 2,8-Quinolinediol | 15450-76-7 | 99.9% | 161.16 | 100 G
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2,8-Quinolinediol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only.
- Biochemical reagent for life science research
- Suitable as a biological material or organic compound
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Medchemexpress LLC Prima-1 | 5608-24-2 | 98.0% | 185.22 | 200 MG
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PRIMA-1 (NSC-281668) is a mutant p53 reactivator that restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.
- Purity of 98.0%
- Solid appearance
- White to off-white color
- Soluble in H2O and DMSO
- Stable for up to 3 years as powder and 2 years in solvent when stored correctly
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Apexbio Technology LLC Lonafarnib 193275-84-2 200mg
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Lonafarnib (CAS 193275-84-2) also known as SCH66336 or Sarasar is a tricyclic orally bioavailable inhibitor of farnesyltransferase (FTase) functioning without peptide or sulfhydryl groups FTase mediates post-translational farnesylation of Ras proteins a modification required for their membrane localization and activation of downstream signaling pathways involved in cellular growth proliferation and survival By inhibiting this enzymatic activity Lonafarnib disrupts Ras translocation to the plasma membrane limiting Ras-mediated signaling Currently Lonafarnib is widely evaluated in preclinical and clinical investigations particularly in oncology contexts
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Apexbio Technology LLC StemRegenin 1 (SR1) 1227633-49-9 200mg
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StemRegenin 1 (SR1 CAS 1227633-49-9) is a purine derivative that functions as an antagonist of the aryl hydrocarbon receptor (AhR) SR1 inhibits AhR signaling in CD34 hematopoietic progenitor cells with an IC50 value of approximately 127 nM Studies demonstrate that SR1 promotes the ex vivo expansion of CD34 cells significantly increasing both the number of CD34-expressing hematopoietic stem cells (HSCs) and their engraftment potential in immunodeficient mouse models Additionally SR1 enables differentiation and robust production of multiple dendritic cell subsets including plasmacytoid dendritic cells (pDCs) and BDCA1 /BDCA3 myeloid DCs from CD34 progenitors indicating its utility for dendritic cell research and hematopoietic stem cell biology
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Apexbio Technology LLC Q-VD(OMe)-OPh 10mg
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Q-VD(OMe)-OPh is a pan-caspase inhibitor structurally identified as quinolyl-valyl-O-methylaspartyl-[2 6-difluorophenoxy]-methyl ketone As a broad-spectrum inhibitor Q-VD(OMe)-OPh reversibly targets multiple caspases involved in apoptotic signaling including initiator caspases (such as caspases 8 9 10 and 12) and executioner caspases (such as caspase 3) thereby blocking intrinsic extrinsic and endoplasmic reticulum-mediated apoptotic pathways In recombinant enzyme assays this inhibitor displays nanomolar-range IC values against caspases 1 3 8 and 9 Due to minimal cytotoxicity at tested concentrations Q-VD(OMe)-OPh serves as a tool compound in apoptosis-related biomedical research applied broadly for dissecting caspase-dependent apoptotic mechanisms and evaluating cytoprotective strategies
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Apexbio Technology LLC Hesperadin 422513-13-1 200mg
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Hesperadin is a small-molecule ATP-competitive inhibitor targeting Aurora B kinase a serine/threonine-protein kinase involved in mitotic regulation By occupying the ATP-binding pocket of Aurora B and adjacent hydrophobic regions Hesperadin suppresses kinase activity with an IC50 approximately 250 nM In mitotic cells Aurora B-mediated phosphorylation of histone H3 Ser-10 is inhibited by Hesperadin this phosphorylation event is widely utilized as a mitotic biomarker Furthermore experimental applications of Hesperadin include investigating cell-cycle dynamics chromosome alignment and spindle checkpoint mechanisms as evidenced by its ability to disrupt proper chromosome alignment and segregation at approximately 40 nM IC50
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000403372 ENDO CNTINH-03 25MG
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Ambeed Methyl 1bromocyclopropanecarbo
Methyl 1-bromocyclopropanecarboxylate, 96999-01-8, 97%
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eMolecules EMOLECULES INC
5000492415 2-TRIFLUOROMETHYL-3-ETHOX 1G
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Medchemexpress LLC MPEG-amine (MW 20000) | 80506-64-5 | 98.0% | (C2H4O)nC3H9NO | 250 MG
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MPEG-amine (MW 20000) is a PEG-based PROTAC linker, crucial for the synthesis of PROTACs. These PROTACs are innovative molecules that utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins, featuring two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other for the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits ubiquitin-proteasome system to degrade target proteins
- Average molecular weight of 20000
- Appears as a solid
- Color is white to off-white
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Ambeed S 2 9HFluoren9yl methoxy c
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dimethylbutanoic acid, 169566-81-8, 95%
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TARGETMOL CHEMICALS INC MAK-683 HYDROCHLORIDE 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 200 mg and bulk. Please contact Fisher for quotes. MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED) (patent US20160176882 A1 compound example 2). MAK683 exhibits IC50s of 59 26 89 nM in EED Alphascreen binding ELISA and LC-MS assay. purity: 98%
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Apexbio Technology LLC AM095 1345614-59-6 200mg
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AM095 (CAS 1345614-59-6) is an orally bioavailable antagonist targeting the lysophosphatidic acid receptor 1 (LPA1) It selectively inhibits recombinant human and mouse LPA1 receptors with IC50 values of 0 98 M and 0 73 M respectively In cell-based assays AM095 suppresses LPA1-mediated chemotaxis in mouse LPA1/CHO and human melanoma A2058 cells (IC50 values 0 78 M and 0 23 M respectively) In vivo studies demonstrate its ability to prevent LPA-triggered histamine release reduce collagen and protein accumulation and limit inflammatory cell infiltration in mouse pulmonary models AM095 serves as a valuable tool for investigating LPA1-associated pathologies
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