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Filtered Search Results
TARGETMOL CHEMICALS INC DBCO-amine 25MG
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Also available in 2 mg, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. DBCO-amine is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. Purity 97.73%
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TARGETMOL CHEMICALS INC GEVOTROLINE 5MG
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502693857 GEVOTROLINE 5MG
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eMolecules EMOLECULES INC
5000190342 1H-BENZIMADAZOLE-5-CARBO 250MG
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eMolecules EMOLECULES INC
5000471436 4-CHLORO-3-NITROQUINOLINE 100G
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eMolecules EMOLECULES INC
5000471352 2-QUINOLINECARBOXALDEHYDE 1G
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eMolecules EMOLECULES INC
5000192656 7-BROMOQUINOLINE 5MG
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eMolecules TETRAHYDROFURAN-2-CARBAL 100MG
5000192165 TETRAHYDROFURAN-2-CARBAL 100MG
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Apexbio Technology LLC MLN8237 (Alisertib) 1028486-01-2 200mg
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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MLN8237 (Alisertib CAS 1028486-01-2) is an orally administered small molecule inhibitor targeting Aurora A kinase (AAK) an enzyme frequently overexpressed in various cancers and linked to tumor proliferation and progression Developed from its predecessor MLN8054 to reduce benzodiazepine-like side effects MLN8237 potently inhibits Aurora A kinase through reversible ATP-competitive binding (Ki 0 43 nmol/L) Given its demonstrated anti-tumor activity in preclinical in vitro and in vivo studies MLN8237 is currently under investigation for treating advanced malignancies
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Apexbio Technology LLC Baricitinib (LY3009104, INCB028050) 1187594-09-7 200mg
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Baricitinib (LY3009104 INCB028050 CAS 1187594-09-7) is an orally bioavailable ATP-competitive inhibitor targeting Janus kinases JAK1 and JAK2 It also exhibits moderate inhibition of TYK2 and weaker inhibition against JAK3 In biochemical assays baricitinib inhibits JAK1 and JAK2 with IC50 values of 5 9 nM and 5 7 nM respectively At concentrations below 50 nM baricitinib suppresses intracellular signaling mediated by several pro-inflammatory cytokines notably IL-6 and IL-23 Due to its mechanistic profile baricitinib is actively explored in inflammatory disease research such as rheumatoid arthritis
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Apexbio Technology LLC A-966492 934162-61-5 200mg
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A-966492 (CAS 934162-61-5) is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) exhibiting a Ki of 1 nM It also inhibits PARP-2 with a Ki of approximately 1 5 nM As a PARP inhibitor this compound interferes with the enzymatic activity essential for DNA repair pathways sensitizing cancer cells to cytotoxic therapies In vitro A-966492 shows effective inhibition in C41 cells with an EC50 of 1 nM and demonstrates moderate oral bioavailability (34-72%) and a half-life of around 1 7-1 9 hours It crosses the blood-brain barrier and has demonstrated activity in preclinical murine cancer models including B16F10 melanoma and BRCA1-deficient MX-1 breast cancer xenografts enhancing the efficacy of chemotherapeutic agents such as temozolomide and carboplatin
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Apexbio Technology LLC Avasimibe 166518-60-1 200mg
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Avasimibe (CAS 166518-60-1) is an orally bioavailable inhibitor of acyl-coenzyme A cholesterol acyltransferase (ACAT) an enzyme involved in cholesterol esterification It exhibits potent inhibition with an IC50 of approximately 60 nM In cell-based studies avasimibe reduces intracellular cholesterol esters in a dose-dependent manner without elevating free cholesterol levels suggesting an advantageous safety profile Additionally avasimibe reduces synthesis and secretion of Apo B 100 a constituent of very low-density lipoprotein (VLDL) in HepG2 cells and increases bile acid synthesis in rat hepatocytes Beyond dyslipidemic modulation and anti-atherogenic activities it influences amyloid precursor protein (APP) trafficking reducing its maturation and subsequent amyloid-beta (A ) peptide generation providing avenues for Alzheimer s disease research
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eMolecules Broadpharm Fmoc-N-amido-PEG10-acid 250mg 724438043 BP-22279 98 000 2101563-45-3 MFCD28122954 751 867 C38H57NO14
Broadpharm Fmoc-N-amido-PEG10-acid 250mg 724438043 BP-22279 98 000 2101563-45-3 MFCD28122954 751 867 C38H57NO14
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eMolecules Ambeed / 8-Hydroxyquinoline-5-carbaldehyde / 100mg / 506389925 / A268393 / / 2598-30-3 / MFCD03425064 / 173.171 / C10H7NO2
Ambeed / 8-Hydroxyquinoline-5-carbaldehyde / 100mg / 506389925 / A268393 / / 2598-30-3 / MFCD03425064 / 173.171 / C10H7NO2
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eMolecules OXETAN-3-AMINE 50MG
5000192490 OXETAN-3-AMINE 50MG
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eMolecules 7-BROMOISOQUINOLINE 250MG
5000192112 7-BROMOISOQUINOLINE 250MG
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