Quinolines and derivatives

Apexbio Technology LLC Ranolazine 95635-55-5 200mg

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Ranolazine (CAS 95635-55-5) is a small molecule that acts as an anti-ischemic agent by selectively inhibiting the late sodium current (INaL) in cardiac cells thereby reducing intracellular sodium accumulation and subsequent calcium overload via the Na /Ca2 exchanger This action mitigates adverse effects associated with ischemia-induced ionic imbalance Ranolazine has also been shown to shift ATP production from fatty acid oxidation toward glucose oxidation reflecting greater metabolic efficiency as glucose oxidation yields more ATP per mole of oxygen consumed Additionally it decreases oxygen consumption and suppresses fatty acid-driven ketogenesis in hepatic cells Ranolazine is widely utilized in research focused on myocardial energy metabolism and ischemic heart disease

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Medchemexpress LLC Mivavotinib | 1312691-33-0 | 344.39 g/mol | C17H21FN6O | 50 MG

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Mivavotinib is a small-molecule research inhibitor with dual activity against spleen tyrosine kinase (SYK) and FMS-like tyrosine kinase 3 (FLT3). Supplied as a laboratory-grade powder, it is intended for research and analytical use only and is not for human therapeutic applications. The compound is characterized by CAS number 1312691-33-0 and a molecular weight of approximately 344.39 g/mol.

• dual inhibition of SYK and FLT3 for mechanistic studies
• supplied as a stable powder suitable for analytical workflows
• well-characterized by CAS and molecular-weight identifiers
• available in small research-friendly package sizes
• intended for research use with appropriate safety precautions

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Medchemexpress LLC 1-tert-Butyl-3-ethoxybenzene | 133073-81-1 | 95.0% | C12H18O | 5 G

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1-tert-Butyl-3-ethoxybenzene is a drug intermediate used for the synthesis of various active compounds. It has a molecular weight of 178.28 and an appearance of light yellow to light brown liquid.

• Used for the synthesis of various active compounds
• Molecular weight: 178.28
• Appearance: Light yellow to light brown liquid

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Apexbio Technology LLC TAK-901 934541-31-8 200mg

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TAK-901 (CAS 934541-31-8) is a small-molecule inhibitor primarily targeting Aurora B kinase with reported IC50 values of 0 0017 M for Aurora-B/INCENP and 0 021 M for Aurora-A/TPX2 Derived from an azacarboline kinase hinge-binding chemotype TAK-901 demonstrates time-dependent selective inhibition of Aurora B suppressing histone H3 phosphorylation and inducing polyploidy in vitro It inhibits proliferation across a range of human cancer cell lines (40 500 nM) and additionally targets kinases such as FLT3 and FGFR2 in cells In preclinical rodent xenograft models TAK-901 reduces tumor growth and induces complete regression in ovarian cancer models A phase I clinical trial has evaluated its dosing and pharmacokinetic characteristics in patients with advanced solid tumors and lymphomas

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Apexbio Technology LLC WYE-125132 (WYE-132) 1144068-46-1 200mg

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WYE-125132 (WYE-132) [CAS 1144068-46-1] is a potent ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) displaying high selectivity over PI3K isoforms It effectively targets both mTORC1 and mTORC2 complexes as demonstrated by inhibition of S6K (T389) and AKT (S473) phosphorylation in immunocomplex assays with an IC50 of 0 19 0 07 nM WYE-125132 suppresses phospho-S6K and phospho-AKT in IGF-I stimulated or mutant cell lines at low nanomolar EC50 values and inhibits proliferation across multiple cancer cell models The compound is widely utilized in research to study mTOR signaling and its role in cellular proliferation and protein synthesis

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Medchemexpress LLC Bapta | 85233-19-8 | MFCD00036255 | 98.1% | 476.43 g/mol | C22H24N2O10 | 200 MG

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Bapta is a selective calcium (Ca2+) chelator used in biochemical and cellular research to buffer intracellular calcium and probe calcium-dependent signaling. It exhibits high selectivity over magnesium and can act as a calcium indicator; it has also been reported to inhibit phospholipase C independent of its chelating activity.

• Selective chelation of calcium with high magnesium selectivity.
• Functions as an intracellular calcium buffer and indicator.
• Useful for studying calcium-dependent signaling and calcium influx.
• Can inhibit phospholipase C independent of calcium chelation.
• Available in solid form and as ready-to-use solution formulations.

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Apexbio Technology LLC LY2608204 1234703-40-2 200mg

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LY2608204 (CAS 1234703-40-2) is a small molecule activator of glucokinase (GK) enhancing its activity as indicated by an EC50 of 42 nM under low glucose conditions In the INS1-E rat insulinoma cell line LY2608204 stimulates glucose metabolism with an EC50 of 579 nM Preclinical studies have demonstrated that administration of LY2608204 leads to dose-dependent reductions in both fasting and postprandial blood glucose levels These properties make LY2608204 a valuable tool for investigating GK modulation and its effects on glucose homeostasis in metabolic disease research

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eMolecules​ 7-BROMOQUINOLINE 1G

5000160442 7-BROMOQUINOLINE 1G

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Medchemexpress LLC Istradefylline | 155270-99-8 | MFCD00928421 | 99.89% | 384.43 | 200 MG

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Istradefylline is a potent, selective, and orally active antagonist of the adenosine A2A receptor, demonstrating a high affinity for this receptor in various experimental models, including those relevant to Parkinson's disease. It exhibits significantly greater affinity for the A2A receptor compared to the A1 receptor, making it a valuable tool for research into neurological conditions and adenosine signaling pathways.

• Highly potent and selective adenosine A2A receptor antagonist.
• Orally active in experimental models.
• Displays neuroprotective effects in Parkinson's disease models.
• Reverses drug-induced catalepsy and hypokinesia.
• Enhances antiparkinsonian activity when combined with dopamine agonists.
• Prevents astrogliosis in primary rat striatal astrocytes.

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