Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC 7-Deazaguanine | 7355-55-7 | HY-34222 | 99.73% | 150.14 | 25 G
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7-Deazaguanine (Compound 1) is a highly selective, well-tolerated, brain-penetrant DYRK1A inhibitor. It is promising for research of cancers and Down's syndrome.
- Highly selective DYRK1A inhibitor
- Well-tolerated
- Brain-penetrant
- Promising for research of cancers
- Promising for research of Down's syndrome
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Medchemexpress LLC 7-Hydroxycarbostyril | 70500-72-0 | 99.05% | 161.16 | 25 G
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7-Hydroxycarbostyril (7-Hydroxy-2(1H)-quinolinone) is a quinolinone derivative. This compound is utilized in the synthesis of brexpiprazole, an orally active antipsychotic agent that functions as a partial agonist for both human 5-HT1A and dopamine D2L receptors.
- A quinolinone derivative.
- Used for the synthesis of brexpiprazole.
- High purity: 99.05%.
- For research use only.
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Medchemexpress LLC Benzyl-PEG5-amine | 86770-77-6 | 98.0% | C17H29NO5 | 25 MG
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Benzyl-PEG5-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are molecules with two ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to a target protein. This mechanism exploits the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC CR-1-31-B | 1352914-52-3 | >98.38% | 507.53 | 25 MG
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CR-1-31-B is a synthetic rocaglate and a potent eIF4A inhibitor. It effectively inhibits eIF4A by disrupting the interaction between eIF4A and RNA, thereby impeding protein synthesis initiation. This compound also interferes with the association of Plasmodium falciparum eIF4A (PfeIF4A) with RNA and has been shown to induce apoptosis in neuroblastoma and gallbladder cancer cells.
- Inhibits eIF4A by disrupting RNA interaction
- Impairs protein synthesis initiation
- Interferes with PfeIF4A association with RNA
- Induces apoptosis in neuroblastoma and gallbladder cancer cells
- Inhibits MUC1-C translation
- Decreases MUC1-C abundance
- Sensitizes gallbladder cancer cells to TRAIL-mediated apoptosis
- Increases reverse glutamine metabolism in pancreatic cancer cells
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Medchemexpress LLC Letrozole (Standard) | 112809-51-5 | C17H11N5 | 200 MG
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Letrozole (CGS 20267) is a potent, selective, reversible, and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. It selectively inhibits estrogen biosynthesis and can be used for breast cancer research.
- Potent, selective, reversible, and orally active non-steroidal inhibitor of aromatase
- Selectively inhibits estrogen biosynthesis
- Used for breast cancer research
- Exhibits anti-tumor effects in rats
- Inhibits growth of MCF-7 epithelial breast cancer cells
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Medchemexpress LLC HY-12304 5mg Medchemexpress, IOX1 CAS:5852-78-8 Purity:>98%
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Medchemexpress, HY-12304 5mg IOX1 CAS:5852-78-8 IOX1, 5-Carboxy-8-hydroxyquinoline, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively. IOX1 also inhibits ALKBH5. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC AL-611 | 2481279-61-0 | 99.9% | C25H33F2N6O8P | 1 MG
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AL-611 is an HCV NS5B polymerase inhibitor with an EC50 of 5 nM. It targets HCV Protease and is involved in anti-infection and metabolic enzyme/protease pathways.
- HCV NS5B polymerase inhibitor (EC50 = 5 nM)
- Targets HCV Protease
- Involved in anti-infection and metabolic enzyme/protease pathways
- Molecular weight: 614.54
- Soluble in DMSO at 125 mg/mL (requires ultrasonication)
- Appears as a white to off-white solid
- Used in research for chronic Hepatitis C treatment
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Medchemexpress LLC 7-APRA | 120709-09-3 | ≥95.0% | 240.28 | 10 G
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7-APRA is a semi-synthetic intermediate of cephalosporin antibiotics. It possesses antibacterial activity and is primarily utilized in the synthesis of Cefaclor and Cefprozil.
- Possesses antibacterial activity
- Used in the synthesis of cephalosporin antibiotics
- Intermediate for drug synthesis
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Medchemexpress LLC PI3K-IN-31 | 1359956-12-9 | 99.3% | C19H23F2N7O3 | 25 MG
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PI3K-IN-31 (Compound 6b) is a potent PI3K inhibitor, demonstrating significant activity against various PI3K isoforms including PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ. This compound has been noted for its anticancer properties.
- Potent PI3K inhibitor
- Exhibits anticancer effects
- Inhibits PI3Kα with an IC50 of 3.7 nM
- Inhibits PI3Kβ with an IC50 of 74 nM
- Inhibits PI3Kγ with an IC50 of 14.6 nM
- Inhibits PI3Kδ with an IC50 of 9.9 nM
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Medchemexpress LLC Amino-PEG9-amine | 474082-35-4 | >98% | C20H44N2O9 | 100 MG
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Amino-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Cayman Chemical 4-HydroxyquInolIn 5g
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A quinoline alkaloid; is a core component of alkyl-4-hydroxyquinoline quorum sensing molecules; has been used as a precursor in the synthesis of compounds with antibacterial activity; has been used as a fluorescent detection reagent for iron(III) in bovine liver samples
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Medchemexpress LLC Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 | 2244602-35-3 | 98.0% | 750.84 g·mol⁻¹ | C30H58N10O12 | 25 MG
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Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 is a branched polyethylene glycol (PEG) linker intended for the construction of antibody-drug conjugates (ADCs). It features a primary amine handle and two azide (N3) termini to enable click chemistry and payload attachment, with high purity and defined molecular weight for controlled bioconjugation.
- Branched PEG linker with amine and azide functional groups.
- High purity: 98.0%.
- Molecular weight: 750.84 g·mol⁻¹.
- Soluble in DMSO at approximately 100 mg/mL; ultrasonic assistance may be required.
- Storage: pure form -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 6 months).
- Suitable for click chemistry and payload attachment in ADC construction.
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000569136 CINOXACIN-200MG
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000569255 PEMPIDINE-200MG
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000569271 RHEIN-200MG
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