Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC AM095 1345614-59-6 200mg
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AM095 (CAS 1345614-59-6) is an orally bioavailable antagonist targeting the lysophosphatidic acid receptor 1 (LPA1) It selectively inhibits recombinant human and mouse LPA1 receptors with IC50 values of 0 98 M and 0 73 M respectively In cell-based assays AM095 suppresses LPA1-mediated chemotaxis in mouse LPA1/CHO and human melanoma A2058 cells (IC50 values 0 78 M and 0 23 M respectively) In vivo studies demonstrate its ability to prevent LPA-triggered histamine release reduce collagen and protein accumulation and limit inflammatory cell infiltration in mouse pulmonary models AM095 serves as a valuable tool for investigating LPA1-associated pathologies
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Aobchem AOBCHEM
5000915829 2 5-DIMETHOXY-4- PROPYLTHIO BE
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Apexbio Technology LLC Mefloquine hydrochloride 51773-92-3 1g
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Mefloquine hydrochloride is a quinoline-based antimalarial compound structurally related to quinidine with demonstrated inhibitory effects on Plasmodium falciparum It functions primarily through modulation of potassium ion channels displaying an IC50 around 1 M against KvLQT1/minK channel currents and approximately 5 6 M against HERG channel currents Research indicates that mefloquine induces cellular oxidative stress modulating intracellular signaling pathways including Akt phosphorylation ERK JNK and AMPK in vitro Current studies also explore its potential cytotoxic activity toward cancer cell lines and evaluate effectiveness against urinary schistosomiasis in phase 2 clinical trials
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Aobchem AOBCHEM
5000907154 METHYL 2-ETHOXY- -HYDROXY- -ME
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Aobchem AOBCHEM
5000910169 ETHYL 2- 2-METHYLQUINOLIN-6-YL
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Apexbio Technology LLC Golvatinib (E7050) 928037-13-2 200mg
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Golvatinib (E7050 CAS 928037-13-2) is a small-molecule inhibitor targeting the tyrosine kinases c-Met and VEGFR-2 Golvatinib inhibits phosphorylation of c-Met in MKN45 gastric cancer cells and VEGFR-2 in human umbilical vein endothelial cells (HUVECs) with IC50 values of 14 nM and 16 nM respectively Additionally it suppresses proliferation of various tumor cells including MKN45 EBC-1 Hs746T and SNU-5 and inhibits tumor growth in xenograft models via reduction of c-Met and VEGFR-2-mediated pathways Golvatinib is utilized in cancer research to explore targeted antitumor efficacy related to angiogenesis and oncogenic signaling
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000746591 MPEG-AMINE MW 20000 1G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000746592 M-PEG10-AMINE 1G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000691215 TC-O 9311 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000746657 ALPELISIB 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000746662 50-C2-C9-4TAIL 1MG
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Chemscene CHEMSCENE
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5000576960 2-CHLORO-6-METHOXY-QUINOLI 25G
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Ambeed 3 2Hydroxyethoxy propanoic aci
3-(2-Hydroxyethoxy)propanoic acid, 89211-34-7, 95%
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Ambeed 3 tertButoxy 2 6 diisopropyl
(3-(tert-Butoxy)-2',6'-diisopropyl-6-methoxy-[1,1'-biphenyl]-2-yl)dicyclohexylphosphane, 2489243-29-8, 98%
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Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | MFCD00673687 | 99.9% | 100 MG
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Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. It exhibits broad-spectrum bactericidal activity primarily by inhibiting bacterial DNA gyrase and also functions as a substrate for ATP-dependent efflux transporters such as P-gp and MRP2.
- Used as a veterinary drug
- Broad-spectrum bactericidal activity
- Inhibits bacterial DNA gyrase
- Substrate for ATP-dependent efflux transporters (P-gp and MRP2)
- Targets P-glycoprotein and bacterial components
- Involves membrane transporter/ion channel and anti-infection mechanisms
- Effective against bovine bacterial respiratory pathogens
- Demonstrates asymmetric transport across Caco-2 cells
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