Quinolines and derivatives
Apexbio Technology LLC BMH-21(Synonyms: BMH21, BMH 21, CID 46835406, RNA polymerase I inhibitor BMH-21, RNA Pol I inhibitor BMH-21), 200mg, CAS: 896705-16-1.
BMH-21 (CAS 896705-16-1) is a planar heterocyclic small molecule DNA intercalator that selectively inhibits RNA polymerase I (Pol I)-mediated transcription It preferentially inserts into GC-rich double-stranded DNA regions leading to Pol I blockade and subsequent degradation of its catalytic subunit RPA194 BMH-21 exhibits cytotoxic activity across various human cancer cell lines independently of the p53 status disrupting nucleolar integrity and RNA synthesis Furthermore BMH-21 promotes p53 expression in epithelial compartments of human prostate tissues demonstrating tissue permeability and highlighting its applicability in anticancer research
Medchemexpress LLC Sulfo-Cy5 azide | 1782950-80-4 | >90.0% | C37H48N6O10S3 | 10MG
Sulfo-Cy5 azide is a water-soluble, azide-functionalized fluorescent dye intended for bioconjugation via click chemistry. It absorbs at 647 nm and emits at 663 nm, and is supplied as a blue powder with a molecular weight of approximately 833.01 g/mol and reported purity ≥90% (HPLC). The reagent is designed for labeling biomolecules in aqueous conditions and should be stored at -20 °C.
- Water-soluble for efficient labeling in aqueous buffers.
- Provides far-red fluorescence (λabs 647 nm, λem 663 nm) for imaging and detection.
- Azide functionality enables copper-catalyzed and strain-promoted click chemistry conjugation.
- High purity (>90.0%) suitable for sensitive applications.
- Blue powder form for easy aliquoting and storage.
- Stable when stored at -20 °C with a typical shelf life of 12 months.
Medchemexpress LLC AL-611 | 2481279-61-0 | 99.9% | C25H33F2N6O8P | 1 ML
AL-611 is an HCV NS5B polymerase inhibitor with an EC50 of 5 nM, intended for research use only.
- Molecular weight of 614.54.
- Purity of 99.93%.
- Appears as a solid, white to off-white.
- Soluble in DMSO (125 mg/mL).
- Store powder at -20°C for up to 3 years.
- Store in solvent at -80°C for 6 months, or -20°C for 1 month.
- Exhibits CC50 > 100 μM and EC50 0.005 μM in Huh-7 cells.
- Involved in a Phase 1 clinical trial for Hepatitis C (NCT03253471).
eMolecules 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | 100361-18-0 | 1G | Purity: 95%
Matrix Scientific | 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | 1G | 100361-18-0 | MFCD08458865
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AdipoGen Quinine HCl dihydrate
Chemical. CAS 6119-47-7. Formula C20H24N2O2 . HCl . 2H2O. MW BD9837. Quinine hydrochloride dihydrate is isolated from the cinchona tree?s bark, is characterized by a bitter taste and shows antipyretic fever-reducing, anti-malarial, analgesic painkilling, anti-viral and anti-inflammatory properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase MAO, an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers.
Medchemexpress LLC Prucalopride succinate | 179474-85-2 | 99.9% | 200 MG
Prucalopride succinate is an orally active, selective, and specific 5-HT4 receptor agonist. It enhances intestinal motility by promoting intestinal nervous system regeneration and exhibits anticancer activity by blocking the PI3K/AKT/mTor pathway. It is used in studies of chronic constipation, pseudo-intestinal obstruction, and cancer.
- Selective and specific 5-HT4 receptor agonist
- Enhances intestinal motility
- Exhibits anticancer activity
- Induces autophagy and apoptosis in A549/A427 cells
- Promotes regeneration of colonic neural stem cells and neurons
Medchemexpress LLC 2-Octyl-4(1H)-quinolone | 80554-60-5 | >=98.0% | 257.37 | 50 MG
2-Octyl-4(1H)-quinolone is a quinolinone alkaloid that can be isolated from *Ruta graveolens*. It is intended for research use only. It has shown antiproliferative activity against human A2780 cells with an IC50 of 12 μM after 2 days by Alamar blue assay. The compound is a solid, white to off-white in color, with the formula C17H23NO. It is classified under Alkaloids and Other Alkaloids, and its initial source is from the plants Rutaceae, specifically *Ruta graveolens Linn.*.
- Quinolone alkaloid.
- Isolated from *Ruta graveolens*.
- For research use only.
- Exhibits antiproliferative activity against human A2780 cells with an IC50 of 12 μM after 2 days by Alamar blue assay.
- Solid, white to off-white in color.
- Chemical formula C17H23NO.
- Classified under alkaloids.
- Sourced from Rutaceae, *Ruta graveolens Linn.*.
Medchemexpress LLC Cyanine5.5 amine | 2097714-45-7 | 753.88 | C46H58Cl2N4O | 10 MG
Cyanine5.5 amine is a near-infrared fluorescent dye bearing a reactive amine group for conjugation to biomolecules, nanoparticles, and polymers. It exhibits excitation at 680 nm and emission at 710 nm, making it suitable for low-background imaging in confocal and fluorescence microscopy applications.
- Near-infrared excitation and emission (680 nm/710 nm) for reduced autofluorescence.
- Amine functional group enables straightforward conjugation to proteins and nanoparticles.
- Appropriate for confocal and fluorescence microscopy and fluorescence-based tracking.
- Available in small and bulk pack sizes to support scouting experiments and scale-up.
AdipoGen Quinine HCl dihydrate
Chemical. CAS 6119-47-7. Formula C20H24N2O2 . HCl . 2H2O. MW BD9837. Quinine hydrochloride dihydrate is isolated from the cinchona tree?s bark, is characterized by a bitter taste and shows antipyretic fever-reducing, anti-malarial, analgesic painkilling, anti-viral and anti-inflammatory properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase MAO, an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers.
AdipoGen Quinine HCl dihydrate
Chemical. CAS 6119-47-7. Formula C20H24N2O2 . HCl . 2H2O. MW BD9837. Quinine hydrochloride dihydrate is isolated from the cinchona tree?s bark, is characterized by a bitter taste and shows antipyretic fever-reducing, anti-malarial, analgesic painkilling, anti-viral and anti-inflammatory properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase MAO, an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers.
eMolecules 5622-36-6 | Methyl 2-(quinolin-6-yl)acetate | Synthonix | MFCD04038669 | 201.225 | C12H11NO2 | 95.000 | COC(=O)Cc1ccc2ncccc2c1 | 100mg | 649427513
Methyl 2-(quinolin-6-yl)acetate | Synthonix | 5622-36-6 | MFCD04038669 | 201.225 | C12H11NO2 | 95.000 | COC(=O)Cc1ccc2ncccc2c1 | 100mg | 649427513
eMolecules 1255942-06-3 | DBCO-amine | Ambeed | MFCD22380759 | 276.339 | C18H16N2O | 98.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 50mg | 682930030
DBCO-amine | Ambeed | 1255942-06-3 | MFCD22380759 | 276.339 | C18H16N2O | 98.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 50mg | 682930030