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Filtered Search Results
Apexbio Technology LLC Refametinib 923032-37-5 200mg
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Refametinib (CAS 923032-37-5) is an orally bioavailable selective allosteric inhibitor of mitogen-activated protein kinase kinases MEK1 and MEK2 It binds to an allosteric site distinct from the ATP-binding pocket thereby inhibiting MEK1 and MEK2 enzymatic activity (IC50 19 nM and 47 nM respectively) and blocking phosphorylation of ERK without interfering with ATP binding Refametinib demonstrates potent inhibition in human tumor cell lines with EC50 values ranging from 2 5 to 15 8 nM and suppresses proliferation in BRAF V600E-mutant lines (GI50 67 89 nM) It induces tumor growth delay and regression in xenograft models supporting its utility in cancer research
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Selleck Chemical LLC Propidium Iodide
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Propidium iodide (PI) is a red-fluorescent DNA stain which penetrates only damaged cellular membranes Propidium iodide (PI) is described for use in the determination of cell viability in cell suspension
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000428318 ACRIDINE ORANGE 10-N 100MG
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Medchemexpress LLC SKA-31 | 40172-65-4 | 99.7% | 200.27 | 50 MG
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SKA-31 is a potent potassium channel activator that potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure. It is suitable for research use only.
- Potent potassium channel activator with specific EC50 values for KCa3.1, KCa2.2, KCa2.1, and KCa2.3.
- Potentiates endothelium-derived hyperpolarizing factor response.
- Lowers blood pressure.
- Activates KCa2/3 channels more potently and selectively than other activators.
- Not acutely toxic and has good pharmacokinetic properties.
- Stimulates KCa3.1 and KCa2.3 in vascular endothelial cells, increasing acetylcholine-induced endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilation.
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![Apexbio Technology LLC prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens] 1mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000096894.png-250.jpg)
Apexbio Technology LLC prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens] 1mg
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Prostate apoptosis response protein PAR-4 2-7 is a short peptide targeting transcriptional regulation pathways It is designed to modulate transcription factor activity thereby influencing apoptosis mechanisms particularly in prostate cells PAR-4 2-7 exerts its biological activity primarily through interaction with transcription factors via a leucine zipper zinc finger domain facilitating apoptosis in transformed or malignant cells while sparing normal cells Based on these properties PAR-4 2-7 holds research potential in studies investigating tumor suppression mechanisms and transcription-mediated apoptosis regulation in oncology and therapeutic research
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Apexbio Technology LLC Nootkatone 4674-50-4 200mg
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Nootkatone (CAS nan) is a naturally derived agent investigated for its neuroprotective effects It is designed to modulate intracellular signaling pathways and enzymatic activities associated with neuroinflammation and oxidative stress thereby regulating neuronal cellular processes Nootkatone exerts its biological activity primarily through modulation of signaling pathways and enzymatic activities linked to neuroinflammation and oxidative stress In animal models specifically lipopolysaccharide (LPS)-induced Alzheimer s disease in mice Nootkatone demonstrates amelioration of cognitive impairment Based on these pharmacological properties Nootkatone holds research potential in neuronal protection cognitive function restoration and elucidation of mechanisms related to neurodegenerative pathology
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Aobchem AOBCHEM
5000866117 8-FLUORO-6-METHYLQUINOLINE 250
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MOLPORT INC 2,5-dimethoxy-N-(3-quinolinyl)benzenesulfonamide | 496014-13-2 | 344.4 g/mol | 10MG
2,5-dimethoxy-N-(3-quinolinyl)benzenesulfonamide | 496014-13-2 | 344.4 g/mol | 10MG
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Medchemexpress LLC Oxaliplatin | 61825-94-3 | 99.99% | 397.29 | 200 MG
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Oxaliplatin is an analytical standard and DNA synthesis inhibitor. It induces DNA crosslinking damage, preventing DNA replication and transcription, and ultimately leading to apoptosis. This product is intended for various research and analytical applications, particularly in cancer research.
- DNA synthesis inhibitor
- Causes DNA crosslinking damage
- Prevents DNA replication and transcription
- Induces apoptosis
- Suitable for cancer research
- Analytical standard grade for reference assays
- Used in qualitative, quantitative, and methodological research experiments
- Applicable in techniques such as HPLC, GC, and MS
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TARGETMOL CHEMICALS INC Telmisartan 200MG
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Also available in 1 g, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Telmisartan (BIBR 277) is an Angiotensin 2 Receptor Blocker. The mechanism of action of telmisartan is as an Angiotensin 2 Receptor Antagonist. Purity 98.78%
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TARGETMOL CHEMICALS INC Tacedinaline 200MG
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Also available in 1 mL, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity. Purity 98.37%
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Medchemexpress LLC Subasumstat | 1858276-04-6 | 578.10 | 200 MG
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Subasumstat (TAK-981) is a first-in-class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.
- Selective inhibitor of SUMOylation enzymatic cascade.
- Potential immune-activating and antineoplastic activities.
- Increases production of type 1 IFN, activating innate effector cells and enhancing antitumor innate immune responses.
- Induces activation of DCs in naive Balb/c mice.
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Apexbio Technology LLC BAPTA 85233-19-8 200mg
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BAPTA (CAS 85233-19-8) is a cell-permeant calcium chelator widely employed in biomedical research to modulate intracellular Ca concentrations By selectively binding cytosolic calcium ions BAPTA effectively buffers rapid changes in Ca levels thereby influencing calcium-dependent signaling pathways and cellular metabolic processes Its application is particularly valuable in neurobiology and cell physiology studies investigating the regulatory roles of intracellular calcium in neuronal activity signal transduction and other calcium-mediated cellular functions
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Ambeed AMBEED
5000866596 8-AMINOQUINOLINE-4-CARBO 100MG
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Ambeed AMBEED
5000866948 OCTAHYDRO-1H-47-METHANOIND 1GR
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