Quinolines and derivatives

eMolecules​ 1952360-91-6 | (Fmoc-amino)-PEG12-C2-carboxylic acid | Chem-Impex | MFCD08064302 | 839.973 | C42H65NO16 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 5g | 686069703

(Fmoc-amino)-PEG12-C2-carboxylic acid | Chem-Impex | 1952360-91-6 | MFCD08064302 | 839.973 | C42H65NO16 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 5g | 686069703

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Medchemexpress LLC Canagliflozin | 842133-18-0 | MFCD18251436 | 99.7% | 444.52 | C24H25FO5S | 200 MG

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Canagliflozin is a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor provided as a research-grade powder for biochemical and pharmacological studies. It exhibits low-nanomolar potency against SGLT2 and is used in in vitro and in vivo experiments to investigate glucose transport and metabolic pathways.

• Selective SGLT2 inhibitor with low-nanomolar IC50 values.
• High purity suitable for analytical and research use (≈99.7% LCMS).
• Solid powder form for flexible formulation and dosing.
• Stable under recommended storage conditions (powder: -20°C and 4°C).
• Molecular weight 444.52 and formula C24H25FO5S.

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Apexbio Technology LLC Refametinib 923032-37-5 200mg

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Refametinib (CAS 923032-37-5) is an orally bioavailable selective allosteric inhibitor of mitogen-activated protein kinase kinases MEK1 and MEK2 It binds to an allosteric site distinct from the ATP-binding pocket thereby inhibiting MEK1 and MEK2 enzymatic activity (IC50 19 nM and 47 nM respectively) and blocking phosphorylation of ERK without interfering with ATP binding Refametinib demonstrates potent inhibition in human tumor cell lines with EC50 values ranging from 2 5 to 15 8 nM and suppresses proliferation in BRAF V600E-mutant lines (GI50 67 89 nM) It induces tumor growth delay and regression in xenograft models supporting its utility in cancer research

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Medchemexpress LLC Sulfo-SPDB-DM4 | 1626359-59-8 | 99.8% | 1075.66 | C46H63ClN4O17S3 | 5 MG

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sulfo-SPDB-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) research that delivers the maytansine-derived cytotoxin DM4 via a cleavable sulfo-SPDB linker. DM4 is an antitubulin maytansinoid that inhibits tubulin polymerization, causing mitotic arrest and apoptotic cell death. The product is supplied as a solid for use in ADC development and related in vitro studies.

• Delivers DM4, a maytansine-derived antitubulin payload, for ADC payload evaluation.
• Cleavable sulfo-SPDB linker enables intracellular release of the cytotoxin.
• High purity (≈99.8%) suitable for research applications.
• Supplied as a solid, white to yellow, shipped on dry ice.
• Soluble in DMSO at 50 MG/ML with ultrasonic assistance; hygroscopic DMSO affects solubility.
• Recommended storage at -80°C, protected from light, under nitrogen.

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Medchemexpress LLC Guanidinoethyl sulfonate | 543-18-0 | MFCD00084865 | 99.9% | 167.19 g/mol | C3H9N3O3S | 5 MG

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Guanidinoethyl sulfonate (taurocyamine) is a small-molecule research reagent that inhibits taurine transport and antagonizes glycine receptors in the central nervous system. It is blood-brain barrier permeable and has been used in neuroprotection studies of ischemic brain injury; it also exhibits weak modulatory effects on GABAA receptors.

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Medchemexpress LLC Disuccinimidyl sulfoxide | 1351828-03-9 | MFCD30497419 | 99.8% | 388.35 g/mol | C14H16N2O9S | 500MG

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Disuccinimidyl sulfoxide (DSSO) is a homobifunctional, amine-reactive, sulfoxide-containing cross-linker developed for cross-linking mass spectrometry workflows. It incorporates two symmetric CID-cleavable sites that produce characteristic fragmentation patterns, enabling confident identification of cross-linked peptides and aiding structural proteomics and protein interaction mapping.

• MS-cleavable sulfoxide core for characteristic CID fragmentation.
• Homobifunctional, N-hydroxysuccinimide ester reactivity toward primary amines.
• Enables confident identification of cross-linked peptides in proteomics studies.
• High purity (≈99.8%) white to off-white solid.
• Suitable for cross-linking model peptides, proteins, and multisubunit complexes.

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