Quinolines and derivatives
Medchemexpress LLC Chlorprothixene (hydrochloride) | 6469-93-8 | 99.9% | 200 MG
Chlorprothixene is a dopamine and histamine receptor antagonist known for its antipsychotic activity. It exhibits high affinity for various human dopamine and histamine receptors.
- Antagonizes human D1, D2, D3, D5, and H1 receptors with low nanomolar Ki values.
- Inhibits 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 in HEK293 cells.
- Antagonizes H1 receptor activity in human HeLa cells.
- Binds to 5-HT7, 5-HT6, and 5-HT2 receptors with high pKi values.
Apexbio Technology LLC NVP-BSK805 2HCl 1092499-93-8 (free base) 200mg
NVP-BSK805 2HCl is a selective ATP-competitive inhibitor targeting Janus kinase 2 (JAK2) JAK2 part of the JAK kinase family mediates signaling through cytokine receptor systems including type II cytokine GM-CSF receptor gp130 and single-chain receptor families By competitively binding the ATP-binding site of JAK2 NVP-BSK805 inhibits downstream STAT5 phosphorylation and JAK-mediated signaling It displays greater than 20-fold selectivity for JAK2 versus other JAK family members (JAK1 JAK3 TYK2) Cell-based assays demonstrate antiproliferative activity against cells expressing JAK2V617F mutations NVP-BSK805 is commonly employed in vitro and in vivo to investigate JAK2-mediated cellular responses oncogenesis and associated signaling pathways