Quinolines and derivatives
Apexbio Technology LLC HyperTrap Q HP Column 5x1ml
HyperTrap Q HP Column is not a small molecule but a high-performance chromatography column designed for biomolecule purification Featuring a strong anion exchange resin with quaternary ammonium functional groups the column enables efficient separation and capture of negatively charged biomolecules such as proteins and nucleic acids based on their charge properties The column supports high binding capacity and robust performance across a range of pH conditions making it suitable for process development scale-up and routine purification workflows in biomedical research particularly for the preparation and analysis of protein therapeutics and other biologically relevant molecules
Apexbio Technology LLC HyperTrap Q HP Column 1ml
HyperTrap Q HP Column is not a small molecule but a high-performance chromatography column designed for biomolecule purification Featuring a strong anion exchange resin with quaternary ammonium functional groups the column enables efficient separation and capture of negatively charged biomolecules such as proteins and nucleic acids based on their charge properties The column supports high binding capacity and robust performance across a range of pH conditions making it suitable for process development scale-up and routine purification workflows in biomedical research particularly for the preparation and analysis of protein therapeutics and other biologically relevant molecules
Apexbio Technology LLC Belinostat (PXD101) 414864-00-9 200mg
Belinostat (PXD101) is a hydroxamic acid-based inhibitor targeting histone deacetylase (HDAC) enzymes Its mechanism involves the suppression of HDAC enzymatic activity leading to increased acetylation of histone proteins H3 and H4 within cells In biochemical assays using Hela cell extracts belinostat exhibits inhibitory activity against HDAC with an IC50 value of approximately 27 nM In tumor cell culture models belinostat induces cytotoxicity and represses cellular proliferation with reported IC50 values ranging roughly from 0 5 M to 10 M varying by cell type and origin making it suitable for research on epigenetic modulation in oncology specifically in studies of bladder prostate and related cancer cell lines
Apexbio Technology LLC Isocytosine 108-53-2 200mg
Isocytosine (CAS 108-53-2) is a non-canonical nucleobase and a structural isomer of cytosine It serves as an analog in nucleic acid research notably as a component of expanded genetic systems such as hachimoji RNA and can pair with isoguanine to model non-standard base pairing Mechanistically isocytosine has been shown to modulate specific signaling pathways and enzyme activities in experimental systems It is widely utilized in molecular biology and genetics to investigate alternative base-pairing nucleic acid stability and the physicochemical properties of synthetic genetic polymers
Apexbio Technology LLC Acridine Orange hydrochloride 65-61-2 50mg
Acridine Orange hydrochloride (65-61-2) is a small-molecule fluorochrome targeting nucleic acids It is designed to bind double-stranded DNA and single-stranded DNA or RNA thereby enabling differential nucleic acid staining in live cells Acridine Orange hydrochloride exerts its biological activity primarily through selective intercalation with nucleic acids and pH-dependent accumulation in acidic organelles resulting in green fluorescence for dsDNA and red/orange fluorescence for ssDNA/RNA In cell-based assays Acridine Orange hydrochloride exhibits cytotoxicity with reported IC50 values typically ranging from 0 5 5 M Based on these pharmacological properties Acridine Orange hydrochloride holds research potential in apoptosis detection assessment of lysosomal integrity and function and antitumor activity studies
Selleck Chemical LLC Ethidium bromide S3689-25mg
Ethidium Bromide (Homidium bromide EtBr EB) is an intercalating agent which resembles a DNA base pair and commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis
Apexbio Technology LLC TAK-438 1260141-27-2 200mg
TAK-438 is a small-molecule inhibitor targeting gastric H K -ATPase It is designed to reversibly block potassium-competitive activity of this enzyme thereby suppressing gastric acid secretion TAK-438 exerts its biological activity primarily through direct potassium-competitive inhibition of the gastric H K -ATPase enzyme In animal studies TAK-438 demonstrates concentration-dependent inhibition of histamine-stimulated acid secretion in rats and dogs with effects persisting beyond 24 hours after oral administration Based on these pharmacological properties TAK-438 holds research potential in studies involving gastric acid physiology and acid-related gastrointestinal disorders
Apexbio Technology LLC Ethidium bromide 1239-45-8 500mg
Ethidium bromide (CAS 1239-45-8) is a small-molecule fluorescent dye widely utilized in molecular biology for nucleic acid visualization It intercalates between the base pairs of double-stranded DNA or RNA resulting in enhanced fluorescence upon binding With an excitation spectrum between 300 360 nm and an emission maximum at 590 nm ethidium bromide is commonly used to stain nucleic acids during agarose gel electrophoresis This property facilitates the detection and analysis of DNA and RNA in applications such as gene expression studies and nucleic acid quantification supporting a broad range of experimental workflows in genomics and molecular diagnostics
Apexbio Technology LLC Ethidium bromide 1239-45-8 250mg
Ethidium bromide (CAS 1239-45-8) is a small-molecule fluorescent dye widely utilized in molecular biology for nucleic acid visualization It intercalates between the base pairs of double-stranded DNA or RNA resulting in enhanced fluorescence upon binding With an excitation spectrum between 300 360 nm and an emission maximum at 590 nm ethidium bromide is commonly used to stain nucleic acids during agarose gel electrophoresis This property facilitates the detection and analysis of DNA and RNA in applications such as gene expression studies and nucleic acid quantification supporting a broad range of experimental workflows in genomics and molecular diagnostics
Apexbio Technology LLC Acridine Orange Staining Kit 500T
Acridine Orange Staining Kit is a fluorescence-based nucleic acid detection reagent designed for distinguishing cellular DNA and RNA particularly in apoptosis assays Acridine Orange is a cell membrane-permeant dye that selectively binds to double-stranded DNA emitting green fluorescence and to RNA or single-stranded DNA emitting orange or red fluorescence It is frequently used in combination with cell-impermeable dyes such as Ethidium Bromide or Propidium Iodide to differentiate viable apoptotic and necrotic cells according to selective membrane permeability and nuclear morphology changes during apoptosis Based on these properties Acridine Orange Staining Kit holds research potential in apoptosis detection and cell viability analysis
Apexbio Technology LLC Acridine Orange Staining Kit 100T
Acridine Orange Staining Kit is a fluorescence-based nucleic acid detection reagent designed for distinguishing cellular DNA and RNA particularly in apoptosis assays Acridine Orange is a cell membrane-permeant dye that selectively binds to double-stranded DNA emitting green fluorescence and to RNA or single-stranded DNA emitting orange or red fluorescence It is frequently used in combination with cell-impermeable dyes such as Ethidium Bromide or Propidium Iodide to differentiate viable apoptotic and necrotic cells according to selective membrane permeability and nuclear morphology changes during apoptosis Based on these properties Acridine Orange Staining Kit holds research potential in apoptosis detection and cell viability analysis
Medchemexpress LLC m-PEG11-amine | 854601-60-8 | 515.64 g/mol | C23H49NO11 | 100 MG
m-PEG11-amine is a PEG-based linker bearing a terminal amine used as a cleavable linker in antibody-drug conjugates (ADCs) and as a PROTAC linker or PEG spacer in conjugation chemistry. It provides a water-soluble spacer that facilitates conjugation to activated esters, carboxylic acids, and other reactive groups, improving solubility and flexibility of the resulting bioconjugates.
- PEG-based linker with a terminal primary amine for conjugation
- Used as a cleavable linker in antibody-drug conjugates (ADCs)
- Suitable as a PROTAC linker or PEG spacer in conjugation chemistry
- Water-soluble spacer improves solubility and flexibility of conjugates
- Available in multiple sizes for research-scale synthesis
Apexbio Technology LLC Cyclocytidine HCl 10212-25-6 200mg
Cyclocytidine HCl (10212-25-6) is a small-molecule nucleoside analog designed to interfere with nucleic acid metabolism and DNA replication Cyclocytidine HCl exerts its biological activity primarily through intracellular conversion into active phosphorylated metabolites that disrupt DNA and RNA synthesis pathways In experimental studies Cyclocytidine HCl demonstrates antitumor activity particularly against leukemia cell lines with reported IC50 values ranging from low micromolar to submicromolar concentrations depending on specific cellular assays and conditions Based on these pharmacological properties Cyclocytidine HCl holds research potential in mechanistic investigations of leukemia pathology and assessment of nucleoside analog efficacy
AdipoGen Ethidium bromide Solution
Chemical. CAS 1239-45-8. Formula C21H20BrN3. MW 394.31. Synthetic. Ethidium bromide EtBr is the most commonly used nucleic acid stain for PAGE or agarose gel electrophoresis. The fluorescence of EtBr increases 21-fold upon binding to double-stranded RNA and 25-fold on binding double-stranded DNA so that destaining the background is not necessary with a low stain concentration 10 µg/ml. Ethidium bromide has been used in a number of fluorimetric assays for nucleic acids. Ethidium bromide intercalates double-stranded DNA and RNA and acts as a frameshift mutagen. It confers a deep red stain to DNA by acting as an intercalating agent between the starch bases. It has been shown to bind to single-stranded DNA although not as strongly and triple-stranded DNA. Because of its ability to bind to DNA, EtBr is an inhibitor of DNA polymerase. It can be used in conjunction with acridine orange to differentiate between viable, apoptotic and necrotic cells.
AdipoGen Ethidium bromide Solution
Chemical. CAS 1239-45-8. Formula C21H20BrN3. MW 394.31. Synthetic. Ethidium bromide EtBr is the most commonly used nucleic acid stain for PAGE or agarose gel electrophoresis. The fluorescence of EtBr increases 21-fold upon binding to double-stranded RNA and 25-fold on binding double-stranded DNA so that destaining the background is not necessary with a low stain concentration 10 µg/ml. Ethidium bromide has been used in a number of fluorimetric assays for nucleic acids. Ethidium bromide intercalates double-stranded DNA and RNA and acts as a frameshift mutagen. It confers a deep red stain to DNA by acting as an intercalating agent between the starch bases. It has been shown to bind to single-stranded DNA although not as strongly and triple-stranded DNA. Because of its ability to bind to DNA, EtBr is an inhibitor of DNA polymerase. It can be used in conjunction with acridine orange to differentiate between viable, apoptotic and necrotic cells.
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