Quinuclidines

Apexbio Technology LLC NS 1619 153587-01-0 10mg

NS 1619 (CAS 153587-01-0) is a small molecule opener of large-conductance calcium-activated potassium (BK) channels By enhancing BK channel activity NS 1619 modulates membrane potential and smooth muscle tone In vascular smooth muscle assays it demonstrates an EC50 of 10 30 M Experimental studies indicate that NS 1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells This compound is commonly utilized in research focused on vascular disorders and oncology to investigate BK channel-related signaling pathways and their physiological or pathological implications

Medchemexpress LLC 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one | 153587-01-0 | MFCD00928190 | 98.1% | 362.23 | C15H8F6N2O2 | 50MG

NS-1619 is a selective activator (opener) of large-conductance, calcium-activated potassium (BK, KCa1.1) channels used as a research reagent to modulate membrane excitability in studies of vascular smooth muscle, neurons, and mitochondrial function. The compound is identified by CAS 153587-01-0, has molecular formula C15H8F6N2O2, and a molecular weight of 362.23 Da.

• Selective BK channel activator for electrophysiology and pharmacology studies.
• Applicable to research on vascular smooth muscle and neuronal excitability.
• C hemical formula C15H8F6N2O2 and molecular weight 362.23 Da.
• High purity (98.1% by LCMS) suitable for analytical and biological assays.
• White to off-white solid form, appropriate for preparation of experimental stock solutions.