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N-Boc-dolaproine-amide-Me-Phe is an amino acid residue of the pentapeptide Dolastatin 10, which is known for its ability to inhibit tubulin polymerization and mitosis, demonstrating anticancer activity.
Amino acid residue of the pentapeptide Dolastatin 10.
Dolastatin 10 inhibits tubulin polymerization and mitosis.
Exhibits anticancer activity.
Intended for research use only.
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Human GIP(3-30), amide TFA is the TFA salt form of human GIP(3-30), amide (HY-P10138). It is a high affinity antagonist of the human GIP receptor in vitro. Human GIP(3-30), amide TFA has potential anti-obesity and anti-diabetic effects.
High affinity antagonist of the human GIP receptor in vitro.
Potential anti-obesity effects.
Potential anti-diabetic effects.
Competitively binds to GIP receptor (GIPR), blocking GIP-mediated cAMP accumulation (Ki=16.8 nM), β-arrestin recruitment (Ki for β-arrestin-1/2 recruitment is 10.6 nM and 10.2 nM) and receptor internalization.
Inhibits GIP mediated insulin secretion and signal transduction in adipocytes.
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Fluorescein-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) consist of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins. This product is intended for research use only.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Intended for research use only
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Fluorescein-PEG3-amine is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. These compounds employ the intracellular ubiquitin-proteasome system for selective degradation of target proteins. The PROTACs achieve this by connecting two different ligands via a linker, with one ligand binding to an E3 ubiquitin ligase and the other to the target protein.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Exploits the intracellular ubiquitin-proteasome system
Selectively degrades target proteins
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