Thienopyridines
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Medchemexpress LLC 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy- | 134-47-4 | 99.5% | 504.49 | 5 MG
AMI-1 free acid is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. It exerts its inhibitory effects by blocking peptide-substrate binding.
- Potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs).
- Inhibits in vitro methylation reactions performed by PRMT1, -3, -4, -6, and Hmt1p.
- Specifically inhibits arginine methyltransferase activity.
- Inhibits cell viability of sarcoma in S180 and U2OS cells.
- Reduces S180 cell viability through the induction of cell apoptosis.
- Inhibits S180 viability in vivo.
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Medchemexpress LLC N-Boc-dolaproine-amide-Me-Phe | 3026596-72-2 | 98.5% | C23H36N2O4 | 5 MG
N-Boc-dolaproine-amide-Me-Phe is an amino acid residue of the pentapeptide Dolastatin 10. Dolastatin 10 is known for its ability to inhibit tubulin polymerization and mitosis, exhibiting anticancer activity.
- Amino acid residue of Dolastatin 10
- Inhibits tubulin polymerization
- Inhibits mitosis
- Exhibits anticancer activity