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Medchemexpress LLC 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy- | 134-47-4 | 99.5% | 504.49 | 5 MG
Supplier: Medchemexpress LLC HY18962A5MG
AMI-1 free acid is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. It exerts its inhibitory effects by blocking peptide-substrate binding.
- Potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs).
- Inhibits in vitro methylation reactions performed by PRMT1, -3, -4, -6, and Hmt1p.
- Specifically inhibits arginine methyltransferase activity.
- Inhibits cell viability of sarcoma in S180 and U2OS cells.
- Reduces S180 cell viability through the induction of cell apoptosis.
- Inhibits S180 viability in vivo.
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