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Thienothiazines

Organic heterocyclic compounds that consist of a thiophene ring fused to a thiazine ring.

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AdipoGen Brinzolamide
SDP

Chemical. CAS 138890-62-7. Formula C12H21N3O5S3. MW 383.51. Synthetic. Brinzolamide is a potent inhibitor of carbonic anhydrases IC50=3.2nM and 45.3nM for CAII and CAIV, respectively that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion. Animal studies have found that one week of twice-daily topical ocular treatment with 2% brinzolamide significantly reduced IOP and enhanced optic nerve head blood flow.

ENCOMPASS_PREFERRED
2

AdipoGen Brinzolamide
SDP

Chemical. CAS 138890-62-7. Formula C12H21N3O5S3. MW 383.51. Synthetic. Brinzolamide is a potent inhibitor of carbonic anhydrases IC50=3.2nM and 45.3nM for CAII and CAIV, respectively that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion. Animal studies have found that one week of twice-daily topical ocular treatment with 2% brinzolamide significantly reduced IOP and enhanced optic nerve head blood flow.

ENCOMPASS_PREFERRED