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Tazarotene (118292-40-3) is a small-molecule agonist targeting retinoic acid receptors (RARs) primarily the RAR- and RAR- subtypes It is designed to modulate gene transcription via selective activation of RARs thereby regulating cellular processes such as proliferation differentiation and apoptosis Tazarotene exerts its biological activity through rapid hydrolysis to its active metabolite tazarotenic acid which binds to RARs and induces expression of genes including the tumor suppressor TIG3 Based on these pharmacological properties Tazarotene holds research potential in the topical treatment of dermatological conditions such as psoriasis acne vulgaris and hyperproliferative skin disorders as well as in mechanistic studies of retinoid-responsive signaling pathways
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