Trioxanes
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Medchemexpress LLC Dihydroartemisinin | 71939-50-9 | 284.35 | 1 G
Dihydroartemisinin (DHA) is a potent antimalarial agent that modulates cellular processes. It up-regulates cytosolic RelA/p65 protein levels while down-regulating nuclear RelA/p65, effectively blocking its nuclear translocation. DHA also induces autophagy and suppresses NF-kB activation in RPMI 8226 cells. Furthermore, it can enhance the anti-tumor effect of photodynamic therapy (PDT) on esophageal cancer cells.
- Potent anti-malaria activity
- Modulates RelA/p65 protein levels
- Blocks nuclear translocation of RelA/p65
- Induces autophagy
- Suppresses NF-kB activation
- Enhances anti-tumor effects of photodynamic therapy
- Derived from Artemisia carvifolia Buch.-Ham. ex Roxb. plants
