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Organic compounds that contain the functional group diazenyl; diazenyl contains two nitrogen atoms bonded via a double bond in the following structure: R−N=N−R′, in which R and R′ can be an aryl or alkyl functional group.
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CAY 10465 is a selective and high-affinity Aryl Hydrocarbon Receptor (AhR) agonist, with a Ki of 0.2 nM. It demonstrates no effect on the estrogen receptor (Ki >100000 nM). In vitro, CAY 10465 (at concentrations from 0.01 nM to 100 μM) has been shown to reduce apolipoprotein A-I (apo A-I) levels in HepG2 cells and inhibit the synthesis of this protein.
Selective AhR agonist: High affinity for AhR with a Ki of 0.2 nM.
No estrogen receptor effect: Shows no activity on the estrogen receptor (Ki >100000 nM).
Inhibits apolipoprotein A-I: Reduces apo A-I levels and inhibits its synthesis in HepG2 cells.
Appearance: Solid, white to off-white.
Storage: Powder: -20°C for 3 years, 4°C for 2 years. In solvent: -80°C for 2 years, -20°C for 1 year.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More