Carboximidamides
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Medchemexpress LLC (+)-Columbianetin | 3804-70-4 | 246.26 | 5 MG
(+)-Columbianetin is an active compound that functions as an inhibitor of JNK and ERK, and an activator of TGFβ signaling. It effectively mitigates UVA-induced cellular damage by reducing phosphorylation of JNK and ERK, decreasing MMP-1 production, and reversing collagen degradation. Additionally, it provides protection against UVB-induced harm to human keratinocytes.
- Inhibits JNK and ERK pathways.
- Activates TGFβ signaling.
- Reduces MMP-1 production.
- Reverses UVA-induced collagen degradation.
- Alleviates UVA-mediated inhibition of Smad2/3 phosphorylation.
- Regulates AP-1 and ASK1-MAPK signaling pathways.
- Inhibits ROS production.
- Protects human keratinocytes against UVB-induced damage.
- Applicable for research related to skin aging.
