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Organic compounds that contain the functional group imine; imine is a functional group or chemical compound containing a carbon–nitrogen double bond, where the nitrogen can subsequently be bonded to a hydrogen atom or a functional group.
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Theliatinib (HMPL-309) is a highly potent EGFR inhibitor with Ki value of 0 05 nM against the wild type EGFR and IC50 values of 3 nM and 22 nM against EGFR and EGFR T790M/L858R mutant It demonstrats 50 fold greater selectivity for EGFR compared to 72 other kinases
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