Proadifen hydrochloride, also known as SKF-525A, is a non-competitive Cytochrome P450 inhibitor with an IC50 value of 19 μM. It reduces monoamine oxidase A activity and N,N-dimethyltryptamine metabolism. This compound is promising for research related to metabolism-related diseases, ovarian carcinoma, inflammation, and dopamine neuron-related diseases.
- Reduces monoamine oxidase A activity
- Reduces N,N-dimethyltryptamine metabolism in liver microsomes
- Inhibits N-demethylation and Acridone formation
- Augments lipopolysaccharide-induced fever
- Exacerbates prostaglandin E2 levels in rats
- Promising for research of metabolism-related diseases
- Promising for research of ovarian carcinoma
- Promising for research of inflammation
- Promising for research of dopamine neuron-related diseases