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Medchemexpress LLC IL-17 modulator 4 | 2446803-65-0 | 99.0% | C27H34N6O2 | 25 MG
IL-17 modulator 4 is a proagent of IL-17 modulator 1, an orally active and highly efficacious IL-17 modulator, promising for research into IL-17A mediated diseases like inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome.
- Proagent of an orally active, highly efficacious IL-17 modulator.
- Promising for research into IL-17A mediated diseases.
- Modulates IL-17A protein-protein interaction by stabilizing its conformation and preventing binding to the IL-17RA receptor.
- Inhibits the IL-17A-mediated signaling pathway and IL-8 secretion in HEKa cells (EC50 of 14 nM).
- Exhibits good pharmacokinetic properties in rat models (low clearance, moderate volume of distribution, 3.7 h half-life, 100% oral bioavailability).
- Appearance: solid, off-white to gray.
